Tetrahedron Lett. 1990, 31 (19), 2693-2696

Synthesis of a Potentially Insulin-Mimetic Phosphodisaccharide

R. Plourde and M. d'Alarcao
Department of Chemistry, Tufts University, Medford MA 02155, USA


Abstract: The synthesis of phosphodisaccharide 1 from myo-inositol and D-glucosamine has been accomplished. This compound is the terminal (and presumably essential) portion of both the putative insulin second messenger and the phosphatidylinositol glycan protein membrane anchor.

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