Publications

Publications

Selected Papers

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  • Mathews, J., Kuchling, F., Baez-Nieto, D., Diberardinis, M., Pan, J. Q., and Levin, M., (2022), Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma, Cancers 14(6): 1499
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  • Murugan, N. J., Vigran, H. J., Miller, K., Golding, A., Pham, Q. L., Sperry, M., Rasmussen-Ivey, C., Kane, A. W., Kaplan, D. L., and Levin, M., (2022), Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis, Science Advances, 8(4): abj2164
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  • Masuelli, S., Sebastian, R., Campoy, E., Branham, M. T., Marzese, D. M., Matthew, S., DeBlas, G., Rodolfo, A., Levin, M., and Roque, M., (2022), When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer, Molecular Medicine, 28:15
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  • Payne, S. L., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J., (2021), Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer, EBioMedicine, 75:103767
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  • Levin, M., (2021), Bioelectrical approaches to cancer as a problem of the scaling of the cellular self, Progress in Biophysics and Molecular Biology, 165: 102-113
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  • Davidian, D., and Levin, M. (2021), Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook, Cold Spring Harbor Perspectives in Biology, doi: 10.1101/cshperspect.a040782
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  • Levin, M., (2021), Bioelectrical approaches to cancer as a problem of the scaling of the cellular self, Progress in Biophysics and Molecular Biology, in press
  • Blackiston, D., Lederer, E., Kriegman, S., Garnier, S., Bongard, J., and Levin, M., (2021), A cellular platform for the development of synthetic living machines, Science Robotics, 6: eabf1571
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  • Cairns, D. M., Rusk, W., Levin, M., Rouleau, N., and Kaplan, D., (2021), Learning and synaptic plasticity in 3D bioengineered neural tissues, Neuroscience Letters, 750: 135799
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  • Levin, M., (2021), Bioelectric Signaling: Reprogrammable Circuits Underlying Embryogenesis, Regeneration, and Cancer, Cell, 184(8): 1971-1989
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  • Biswas, S., Manicka, S., Hoel, E., and Levin, M., (2021), Gene Regulatory Networks Exhibit Several Kinds of Memory: Quantification of Memory in Biological and Random Transcriptional Networks, iScience, 24(3): 102131
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  • Selberg, J., Jafari, M., Mathews, J., Jia, M., Pansodtee, P., Dechiraju, H., Wu, C., Cordero, S., Flora, A., Yonas, N., Jannetty, S., Diberardinis, M., Teodorescu, M., Levin, M., Gomez, M., and Rolandi, M., (2020), Machine Learning-Driven Bioelectronics for Closed-Loop Control of Cells, Advanced Intelligent Systems, 2000140
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  • Pezzulo, G., Lapalme, J., Durant, F., and Levin, M., (2020), Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration, Philosophical Proceedings of the Royal Society B, in press
  • Pai, V., Cervera, J., Mafe, S., Willocq, V., Lederer, E., and Levin, M., (2020), HCN2 Channel-induced Rescue of Brain Teratogenesis via local and long-range bioelectric repair, Frontiers in Cellular Neuroscience, 14: 136
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  • Rouleau, N., Bonzanni, M., Erndt-Marino, J., Sievert, K., Ramirez, C., Rusk, W., Levin, M., and Kaplan, D., (2020), A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure to gabapentinoids, Biomolecules, 10: 1196
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  • Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin‐Dogru, D., Sousa, J. F., Aggouras, A. N., Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., Whited, J. L., (2020), von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration, Evolution & Development, 1–15
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  • Jajoo, A., Donlon, C., Shnayder, S., Levin, M., and McVey, M., (2020), Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants, Scientific Reports, 10: 4512
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  • Herrera-Rincon, C., Pare, J-F., Martyniuk, C. J., Jannetty, S. K., Harrison C., Fischer, A., Dinis, A., Keshari, V., Novak, R., and Levin, M., (2020), An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity, NPJ Regenerative Medicine, 5:2
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  • Srivastava, P., Kane, A., Harrison, C., and Levin, M., (2020), A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration, Bioelectricity, 3(1): 42-67
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  • Kriegman, S., Blackiston, D., Levin, M., and Bongard, J., (2020), A scalable pipeline for designing reconfigurable organisms, Proceedings of the National Academy of Sciences of the United States, doi/10.1073/pnas.1910837117
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  • Kamaldinov, T., Erndt-Marino, J., Levin, M., Kaplan, D. L., and Hahn, M. S., (2020), Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials, Bioelectricity, 2(1): 21-32
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  • Levin, M., Selberg, J., and Rolandi, M., (2019), Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine, iScience, 22: 519–533
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  • Finkelstein J., McLaughlin K., Levin M. (2019), Interdisciplinary Approach Needed to Crack Morphogenesis, The Scientist, December 2019
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  • Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J., (2019), L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development, PNAS, 116(43): 21592-21601
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  • Grasman, J., Williams, M., Razis, C., Bonzanni, M., Golding, A., Cairns, D. M., Levin, M., and Kaplan, D. L., (2019), Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation, ACS Biomater. Sci. Eng., 5(10): 5327-5336
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  • Payne, S. L., Levin, M., and Oudin, M. J., (2019), Bioelectric control of metastasis in solid tumors, Bioelectricity, 1(3): 114-130
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  • Punjiya, M., Nehad, H. R., Mathews, J., Levin, M., Sonkusale, S., (2019), A flow through device for simultaneous dielectrophoretic cell trapping and AC electroporation, Scientific Reports, 9:11988
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  • Whited, J., and Levin, M., (2019), Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities, Current Opinion in Genetics & Development, 57: 61-69
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  • Churchill, C. D. M., Winter, P., Tuszynski, J. A., and Levin, M., (2019), EDEn – Electroceutical Design Environment: An Ion Channel Database with Small Molecule Modulators, iScience, 11: 42-56
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  • Sundelacruz, S., Moody, A. T., Levin, M., and Kaplan, D., (2019), Membrane potential depolarization alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells, Bioelectricity, 1(1): 56-66
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  • Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J., Carabello, H., Kaplan, D. L., and Levin, M., (2018), Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb, Cell Reports, 25(6): 1593-1609
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  • Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L., (2018), Ivermectin promotes peripheral nerve regeneration during wound healing, ACS Omega, 3(10): 12392-12402
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  • Busse, S. M., McMillen, P. T., and Levin, M., (2018), Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals, Development, 145(19). pii: dev164210
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  • Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M., (2018), HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns, Nature Communications, 9(1): 998
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  • Cairns, D. M., Boorgu, D. S. S. K., Levin, M., and Kaplan, D. L., (2018), Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells, Biology Open, 7(1): bio031807
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  • Herrera-Rincon, C., and Levin, M., (2018), Booting up the organism during development: pre-behavioral functions of the vertebrate brain in guiding body morphogenesis, Communicative & Integrative Biology, 11(1): e1433440
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  • Moore, D., Walker, S., and Levin, M., (2017), Cancer as a Disorder of Patterning Information: computational and biophysical perspectives on the cancer problem, Convergent Science Physical Oncology, 3(4): 043001
  • Adams, D. S., Tseng. A-S., and Levin, M., (2017), Using optogenetics in vivo to stimulate regeneration, in K. Appasani (Ed.), Optogenetics: From Neuronal Function to Mapping and Disease Biology, Cambridge University Press: Cambridge, UK, p. 66-76
  • Tuszynski, J., Tilli, T. M., and Levin, M., (2017), Ion channel and neurotransmitter modulators as electroceutical approaches to the control of cancer, Current Pharmaceutical Design, 23(32): 4827-4841
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  • Pare, J-F., Martyniuk, C. J., and Levin, M., (2017), Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis, npj Regenerative Medicine, 2:15
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  • Blackiston, D., Vien, K., and Levin, M., (2017), Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity, npj Regenerative Medicine, 2:8
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  • Lobo, D., Lobikin, M., and Levin, M., (2017), Discovering novel phenotypes with automatically inferred dynamic models: partial melanocyte conversion in Xenopus, Scientific Reports, 7: 41339
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  • Levin, M., Pezzulo, G., and Finkelstein, J. M., (2017), Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form, Annual Review of Biomedical Engineering, 19: 353-87
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  • Herrera-Rincon, C., Guay, J., and Levin, M., (2016), Bioelectrical coordination of cell activity toward anatomical target states: an engineering perspective on regeneration, Chapter 4 in D. Gardiner (Ed.), Regenerative Engineering and Developmental Biology: Principles and Applications, CRC Press: Boca Raton, FL, p. 55-112
  • Golding, A., Guay, J. A., Herrera-Rincon, C., Levin, M., and Kaplan, D. L., (2016), A Tunable Silk Hydrogel Device for Studying Limb Regeneration in Adult Xenopus laevis, PLoS One 11, e0155618
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  • Lobo, D., Morokuma, J., and Levin, M., (2016), Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation, Bioinformatics, doi: 10.1093/bioinformatics/btw299
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  • D. S. Adams, S. G. M. Uzel, J. Akagi, D. Wlodkowic, V. Andreeva, P. C. Yelick, A. Devitt-Lee, J-F. Pare, and Michael Levin, (2016), "Bioelectric signaling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome", Journal of Physiology, 12: 3245-3270
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  • Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M., (2016), "Use of genetically encoded, light-gated ion translocators to control tumorigenesis", Oncotarget, 7(15): 19575-19588
  • Li, C., Levin, M., and Kaplan, D., (2016), "Bioelectric modulation of macrophage polarization", Scientific Reports, 6:21044, doi:10.1038/srep21044
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  • Sundelacruz, S., Levin M., and Kaplan, D. L., (2015), "Comparison of the depolarization response of human mesenchymal stem cells from different donors", Scientific Reports, 5:18279, doi:10.1038/srep18279
  • Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M., (2015),"Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms", International Journal of Molecular Sciences, 16: 27865–27896
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  • Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M., (2015), "Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation", Science Signaling, 8(397): ra99
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  • Levin, M., (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25(24): 3835-3850
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  • Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., and Kaplan, D. L., (2015), Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures, Brain and Behavior, 5(1): 24-38
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  • Pai, V., Lemire, J. M., Pare, J-F., Lin, G., Chen, Y., and Levin, M., (2015), Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation, Journal of Neuroscience, 35(10): 4366-4385
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  • Lobo, D., and Levin, M., (2015), Inferring regulatory networks from experimental morphological phenotypes: a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
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  • Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M., (2015), A novel method for inducing nerve growth via modulation of host resting potential, Neurotherapeutics, 12: 170-184
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  • Chernet, B., and Levin, M., (2014), Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range, Oncotarget, 5(10): 3287-3306
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  • Sundelacruz, S., Levin, M., and Kaplan, D. L., (2013), Depolarization Alters Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells, Tissue Engineering Part A, 19 (17-18): 1889-1908
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  • Chernet, B. T., and Levin, M., (2013), Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development, Disease Models & Mechanisms, 6(3): 595-607
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  • Levin, M., (2011), The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer, Regenerative Medicine, 6(6): 667-673
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  • Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M., (2012), Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis, Development, 139(2): 313-323
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  • Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and Omenetto, F., (2011), Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes, Biomedical Optics Express, 2(8): 2383-2391
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  • Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D., Branch, M. R., and Adams, D. S., (2011), Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail, PLoS One, 6(9): e24953
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  • Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M., (2010), A second-generation device for automated training and quantitative behavior analyses of molecularly-tractable model organisms, PLoS One, 5(12): e14370
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  • Lange, C., Prenninger, S., Knuckles, P., Taylor V., Levin, M., and Calegari, F., (2011), “The H+ Vacuolar ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex”, Stem Cells and Development, 20(5): 1-8
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  • Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and M. Levin, (2010), "Induction of vertebrate regeneration by a transient sodium current”, Journal of Neuroscience, 30(39): 13192-13200
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  • N. J. Oviedo, J. Morokuma, P. Walentek, I. P. Kema, M. B. Gu, J. M. Ahn, J. S. Hwang, T. Gojobori, and M. Levin, (2010), "Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration”, Developmental Biology, 339: 188-199
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  • Blackiston, D. J., K. McLaughlin, and Levin, M., (2009), "Bioelectric controls of cell proliferation: ion channels, membrane voltage, and the cell cycle”, Cell Cycle, 8(21): 3519-3528
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  • Levin, M. (2009), "Bioelectric mechanisms in regeneration: Unique aspects and future perspectives", Seminars in Cell and Developmental Biology, 20: 543-556
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  • Levin, M., (2009), “Errors of Geometry: regeneration in a broader perspective”, Seminars in Cell and Developmental Biology, 20(6): 643-645
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  • Levin, M., Sundelacruz, S., Levin M., Kaplan, D. L., (2009), "Role of membrane potential in the regulation of cell proliferation and differentiation”, Stem Cell Reviews, 5(3): 231-46
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  • Tseng, A-S., and Levin, M., (2008), "Tail regeneration in Xenopus laevis as a model for understanding tissue repair”, Journal of Dental Research, 87(9): 806-816
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  • Morokuma, J., Blackiston, D., Adams, D. S., Seebohm, G., Trimmer, B., and Levin, M., (2008), "Modulation of potassium channel confers a hyper-proliferative invasive phenotype on embryonic stem cells”, Proceedings of the National Academy of Science, 105(43): 16608-16613
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  • Sundelacruz, S., M. Levin, and D. L. Kaplan, (2008), "Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells”, PLoS One, 3(11): e3737, 1-15
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  • Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., and Levin, M., (2007), "Apoptosis is required during early stages of tail regeneration in Xenopus laevis", Developmental Biology, 301: 62-69
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  • Adams, D. S., Masi, A., and Levin, M. (2007), "H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration", Development, 134: 1323-1335
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  • Oviedo, N. J., Levin, M., (2007), "smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis", Development, 134(17): 3121-3131
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  • Adams, D. S., and Levin, M., (2006), "Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets", Genesis, 44: 530-540
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