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Current projects in the lab include:

  1. Investigating potential roles of error-prone DNA polymerases in DNA double-strand break repair.
  2. Determing the genetic components and molecular mechanisms of alternative end-joining repair pathways.
  3. Using inducible I-SceI endonuclease and CRISPR-Cas9 systems to determine the ways that various repair pathways are used in different tissues and developmental stages.
  4. Identifying the hierarchy of proteins and pathways that repair base damage.
  5. Determining the relationship between homologous recombination repair and mutagenesis.
  6. Elucidating the relationship between structure-forming DNA sequences, the proteins that remove them, and how they can induce genome instability.

Watch a video in which three undergraduates describe why they do research and talk about their projects.