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McVey lab Publications

Hanscom T, McVey M. (2020). Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution. Cells, 9:1657. doi: 10.3390/cells9071657. [PDF]

Jajoo A*, Donlon C*, Shnayder S*, Levin M, McVey M. (2020). Sertraline-induced DNA damage and cellular toxicity in Drosophila is ameliorated by antioxidants. Sci Rep 10, 4512, doi: 10.1038/s41598-020-61362-y. [PDF]

Marygold SJ, Attrill H, Speretta E, Warner K, Magrane M, Berloco M, Cotterill S, McVey M, Rong Y, Yamaguchi M. (2020). The DNA polymerases of Drosophila melanogaster. Fly, doi: 10.1080/19336934.2019.1710076. [PDF]

McVey M, Pechenik J. (2020). Poetry in the Undergraduate Biology Classroom. American Biology Teacher 82: 416-420. [PDF]

Kocak E, Dykstra S, Nemeth A, Coughlin CG, Rodgers K, McVey M. (2019). The Drosophila melanogaster PIF1 helicase promotes survival during replication stress and processive DNA synthesis during double-strand gap repair. Genetics, doi: 10.1534/genetics.119.302665. [PDF]

Cassidy D, Epiney DG, Salameh C, Zhou LT, Salomon RN, Schirmer AE, McVey M, Bolterstein E. (2019). Evidence for premature aging in a Drosophila model of Werner syndrome. Exp Gerontol. 127: 110733. [PDF]

Hanscom T, Khodaverdian VY, McVey M. (2018). Recovery of alternative end-joining repair products from Drosophila embryos. Methods Enzymol 601: 91-110. [PDF]

Khodaverdian VY, Hanscom T, Yu AM, Yu T, Mak V, Brown A, Roberts SA, McVey M. (2017). Secondary-structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks. Nucleic Acids Research 45: 12848-12861. [PDF]

Khodaverdian VY and McVey M. (2017). Rapid detection of γ-H2Av foci in ex vivo MMS-treated Drosophila imaginal discs. Methods Mol Biol. 1644: 203-211. [PDF]

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Scharer O, McVey M. (2017). The helicase-like and polymerase domains of Drosophila DNA polymerase theta cooperate during alternative end joining and interstrand crosslink repair. PLoS Genetics 13: e1006813. [PDF]

Alexander JL, Beagan K, Orr-Weaver TL, McVey M. (2016) Multiple mechanisms contribute to double-strand break repair at re-replication forks in Drosophila follicle cells. Proc Natl Acad Sci USA 48: 13809-13814. [PDF]

McVey M, Khodaverdian V, Meyer D, Cerqueira P, Heyer WD. (2016). Eukaryotic DNA polymerases in homologous recombination. Annual Review of Genetics 50: 393-421 [PDF]

Beagan K, McVey M. (2016). Linking DNA polymerase theta structure and function in health and disease. Cellular and Molecular Life Sciences 73: 603-15. [PDF]

Rodgers K and McVey M. (2016). Error-prone repair of DNA double-strand breaks. Journal of Cellular Physiology 231: 15-24. [PDF]

Kloosterman WP, Francioli LC, Fereydoun H, Marschall T, Hehir-Kwa JY, Abdellaoui A, Lameijer E, Moed MH, Koval V, Renkens I, van Roosmalen MJ, Arp P, Karssen LC, Coe BP, Handsaker RE, Suchiman ED, Cuppen E, Thung DT, McVey M, Wendl MC, Genome of the Netherlands Consortium, Uitterlinden A, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Schönhuth A, Eichler EE, de Bakker PIW, Ye K, Guryev V. (2015). Characteristics of de novo structural changes in the human genome. Genome Research 25: 792-801. [PDF]

McVey M. (2014). RPA puts the brakes on MMEJ. Nature Structural & Molecular Biology 21: 348-349. [PDF]

Bolterstein E, Rivero R, Marquez M, McVey M. (2014). The Drosophila Werner Exonuclease participates in an exonuclease-independent response to replication stress. Genetics 197: 643-52. [PDF]

Medina CO, Lattin CR, McVey M, Romero LM. (2013). There is no correlation between glucocorticoid receptor mRNA expression and protein binding in the brains of house sparrows (Passer domesticus). Gen Comp Endocrinol 193: 27-36. [PDF]

Thomas AM, Hui C, South A, McVey M. 2013. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2. G3 (Bethesda). 3(1): 91-9.3538347. [PDF]

Kane DP, Shusterman M, Rong Y, McVey M. 2012. Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. PLoS Genetics 8(4): e1002659. [PDF]

Garcia AM, Salomon R, Witsell A, Liepkalns J, Calder RB, Lee M, Lundell M, Vijg J, McVey M. 2011. Loss of the Bloom Syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biology 12: R121. [PDF]

Yu AM and McVey M. 2010. Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. Nucleic Acids Research 38: 5706-5717. [PDF] [Supplementary Data]

McVey M. 2010. Strategies for DNA Interstrand Crosslink Repair: Insights From Worms, Flies, Frogs, and Slime Molds. Environmental and Molecular Mutagenesis 51: 646-658. [PDF]

Chan S H, Yu AM, McVey M. 2010. Drosophila DNA polymerase theta plays dual roles in alternative end joining. PLoS Genetics 6(7): e1001005. [PDF]

Witsell A, Kane DP, McVey M. 2010. Super-sized deletions: improved transposon excision screens using a mus309 mutant background. Fly (Austin) 4: 137-140. [PDF]

Witsell A , Kane DP, Rubin S, McVey M. 2009. Removal of the Bloom Syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila. Genetics 183: 1187-1193. [PDF]

McVey M. and Lee SE. 2008. MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends in Genetics 24: 529-538. [PDF] [Cover]

Other publications

McVey M, Andersen S, Broze GJ, Sekelsky JJ. 2007. Multiple roles for the Drosophila DmBlm helicase in maintenance of genome stability. Genetics 176: 1979-1992. [PDF] [Supplementary Data]

Rybarczyk BJ, Baines AT, McVey M, Thompson JT, Wilkins HR. 2007. A case-based approach increases student learning outcomes and comprehension of cellular respiration concepts. Biochemistry and Molecular Biology Education 35: 181-186. [PDF]

McVey M, Radut D, Sekelsky JJ. 2004. End-joining repair of double-strand breaks in Drosophila is largely DNA ligase IV independent. Genetics 168: 2067-2076. [PDF]

McVey M, LaRocque JR, Adams MD, Sekelsky JJ. 2004. Formation of deletions during double strand break repair in Drosophila DmBlm mutants occurs after strand invasion. Proc. Natl. Acad. Sci. USA 101: 15694-15699. [PDF]

McVey M, Adams MD, LaRocque JR, Sekelsky JJ. 2004. Evidence for multiple cycles of strand invasion during repair of double-strand gaps in Drosophila. Genetics 167: 699-705. [PDF]

Baines AT, McVey M, Rybarczyk B, Thompson JT, Wilkins HR. 2004. The mystery of the toxic flea dip: an interactive approach to teaching aerobic cellular respiration. Cell Biology Education 3: 62-68. [PDF]

Adams MD, McVey M (co-first author), Sekelsky JJ. 2003. Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing. Science 299: 265-267. [PDF]

McVey M, Kaeberlein M, Tissenbaum HA, Guarente L. 2001. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics 157: 1531-1542. [PDF]

Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L. 2001. The Saccharomyces cerevisiae WRN homologue Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO Journal 20: 905-913. [PDF]

Stone EM, Reifsnyder C, McVey M, Gazo B, Pillus L. 2000. Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae. Genetics 155: 509-522. [PDF]

Kaeberlein M, McVey M (co-first author), Guarente L. 1999. SIR2/3/4 and SIR2 alone regulate life span in Saccharomyces cerevisiae by two different mechanisms. Genes and Development 13: 2570-80. [PDF]