Publications
All Peer-reviewed Publications
2021
Levin, M., (2021), Unlimited Plasticity of Embodied, Cognitive Subjects:
a new playground for the UAL framework, Biology and Philosophy, in press
Cairns, D. M., Rusk, W., Levin, M., Rouleau, N., and Kaplan, D., (2021),
Learning and Synaptic Plasticity in 3D Bioengineered Neural Tissues,
Neuroscience Letters, in press
Sperry, M. M., Murugan, N. J., Levin, M., (2021), Zoological and imaging methods to study
Protista whole-body regeneration & repair using Physarum polycephalum,
Methods in Molecular Biology, in press
Levin, M., (2021), Bioelectric Signaling: Reprogrammable Circuits
Underlying Embryogenesis, Regeneration, and Cancer, Cell, in press
Bongard, J., and Levin, M., (2021), Living things are not (20th Century) machines:
updating mechanism metaphors in light of the modern science of machine behavior,
Frontiers in Ecology and Evolution, in press
Levin, M., Keijzer, F., Lyon, P., and Arend, D., (2021), Uncovering cognitive similarities
and differences, conservation and innovation,
Philosophical Transactions of the Royal Society B, 375 (1820): 20200458 [cover]
PDF
Lyon, P., Keijzer, F., Arendt, D., and Levin, M., (2021), Reframing cognition:
getting down to biological basics,
Philosophical Transactions of the Royal Society B, 376 (1821): 20190750 [cover]
PDF
Pezzulo, G., Lapalme, J., Durant, F., and Levin, M., (2021), Bistability of Somatic Pattern Memories:
Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration,
Philosophical Proceedings of the Royal Society B, 375: 20190765
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Biswas, S., Manicka, S., Hoel, E., and Levin, M., (2021), Gene Regulatory Networks
Exhibit Several Kinds of Memory: Quantification of Memory in Biological and Random Transcriptional Networks,
iScience, in press
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Nanos, V., and Levin, M., (2021), Rewiring Endogenous Bioelectric Circuits
in the Xenopus laevis Embryo Model, Methods in Molecular Biology, 2258:93-103
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Pentagna, N., Pinheiro da Costa, T., Soares Dos Santos, F., Martins de Almeida
F., Martinez, A. M. B., Abreu, J. G., Levin, M., and Carneiro, K., (2021),
Epigenetic control of myeloid cells behavior by Histone Deacetylase Activity (HDAC)
during tissue and organ regeneration in Xenopus laevis,
Developmental and Comparative Immunology, 114:103840
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2020
Cervera, J., Ramirez, P., Levin, M., and Mafe, S., (2020), Community effects allow bioelectrical
reprogramming of cell membrane potentials in multicellular aggregates: Model simulations, Physical Review E, 102: 052412
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Fields, C., and Levin, M., (2020), How Do Living Systems Create Meaning?, Philosophies, 5(4): 36
PDF
Levin, M., (2020), Life, death, and self: Fundamental questions of primitive cognition
viewed through the lens of body plasticity and synthetic organisms,
Biochemical and Biophysical Research Communications, in press
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Selberg, J., Jafari, M., Mathews, J., Jia, M., Pansodtee, P., Dechiraju, H., Wu, C.,
Cordero, S., Flora, A., Yonas, N., Jannetty, S., Diberardinis, M., Teodorescu, M.,
Levin, M., Gomez, M., and Rolandi, M., (2020), Machine Learning-Driven Bioelectronics
for Closed-Loop Control of Cells, Advanced Intelligent Systems, 2000140
[cover]
PDF
Sousounis, K., Erdogan, B., Levin, M., and Whited, J., (2020), Precise control of
ion channel and gap junction expression is required for patterning of the regenerating axolotl limb,
International Journal of Developmental Biology, 64: 485-494
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Fields, C., and Levin, M., (2020), Why isn't sex optional? Stem-cell competition,
loss of regenerative capacity, and cancer in metazoan evolution,
Communicative & Integrative Biology, 13(1): 170-183
PDF
Levin, M., and Dennett, Daniel C., (2020), How to understand cells,
tissues and organisms as agents with agendas, Aeon Essays
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Shah, D., Yang, B., Kriegman, S., Levin, M., Bongard, J., and Kramer-Bottiglio, R., (2020),
Shape changing robots: bioinspiration, simulation, and physical realization,
Advanced Materials, in press
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Fields, C., and Levin, M., (2020),
Does evolution have a target morphology?,
Organisms, 4(1): 57-76
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Jia, M., Dechiruji, H., Selberg J., Pansodtee P., Mathews, J., Wu, C., Levin, M., Teodorescu, M., and Rolandi, M., (2020),
Bioelectronic Control of Chloride Ions and Concentration with Ag/AgCl Contacts,
APL Materials, 8(9): 091106
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Levin, M., (2020), How Groups of Cells Cooperate to Build Organs and Organisms, The Scientist [cover]
PDF
Bischof, J., Day, M., Miller, K., LaPalme, J., and Levin, M., (2020),
Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria,
Developmental Biology, 467 (1-2): 51-65 [cover]
PDF
Kuchling, F., Friston, K., Georgiev, G., and Levin, M., (2020), Integrating Variational Approaches to Pattern Formation
into a Deeper Physics: Reply to comments on "Morphogenesis as Bayesian Inference: A Variational Approach to Pattern Formation
and Manipulation in Complex Biological Systems", Physics of Life Reviews, 33:125-128
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Leronni, A., Bardella, L., Dorfmann, L., Pietak, A., and Levin, M., (2020),
On the coupling of mechanics with bioelectricity and its role in morphogenesis,
Journal of the Royal Society Interface, 17: 20200177
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Hoel, E., and Levin, M., (2020), Emergence of Informative Higher Scales in Biological Systems:
a computational toolkit for optimal prediction and control, Communicative & Integrative Biology, 13(1): 108-118
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Rouleau, N., Bonzanni, M., Erndt-Marino, J., Sievert, K., Ramirez, C., Rusk, W., Levin, M., and Kaplan, D., (2020),
A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure
to gabapentinoids, Biomolecules, 10: 1196
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Levin, M., Bongard, J., and Lunshof, J.E, (2020), Applications and ethics of computer-designed organisms,
Nature Reviews Molecular Cell Biology, 21: 655–656
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Levin, M., (2020), Opinion: Use the Pandemic to Expand the Lab to the Home, The Scientist
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Williams, K., Bischof, J., Lee, F., Miller, K., LaPalme, J., Wolfe, B., and Levin, M., (2020),
Regulation of axial and head patterning during planarian regeneration by a commensal bacterium,
Mechanisms of Development, 163:103614 [cover]
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Gawne, R., McKenna, K., and Levin, M., (2020), Competitive and Coordinative Interactions between Body Parts
Produce Adaptive Developmental Outcomes, BioEssays, 42: 1900245 [cover]
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Fields, C., and Levin, M., (2020), Scale-Free Biology: Integrating Evolutionary and Developmental Thinking,
BioEssays, 42: 1900228
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Pai, V., Cervera, J., Mafe, S., Willocq, V., Lederer, E., and Levin, M., (2020), HCN2 Channel-induced Rescue of Brain
Teratogenesis via local and long-range bioelectric repair, Frontiers in Cellular Neuroscience, 14: 136
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Cervera, J., Levin, M., Mafe, S., (2020),
Bioelectrical Coupling of Single-Cell States in Multicellular Systems,
J. Phys. Chem. Lett. 11, XXX, 3234-3241, doi.org/10.1021/acs.jpclett.0c00641
PDF
Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin‐Dogru, D., Sousa, J. F., Aggouras, A. N.,
Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., Whited, J. L., (2020),
von Willebrand factor D and EGF domains is an evolutionarily conserved and required
feature of blastemas capable of multitissue appendage regeneration, Evolution & Development, 22: 297-311 [cover]
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Jajoo, A., Donlon, C., Shnayder, S., Levin, M., and McVey, M., (2020), Sertraline induces DNA damage and cellular
toxicity in Drosophila that can be ameliorated by antioxidants, Scientific Reports, 10: 4512
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Levin, M., (2020), Revisiting Burr and Northrop's 'The Electro-Dynamic Theory of Life',
Biological Theory, 15:83–90
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Sousounis, K., Bryant, D. M., Fernandez, J. M., Eddy, S. S., Tsai, S. L., Gundberg, G. C., Han, J., Courtemanche, K.,
Levin, M., and Whited, J. L., (2020), Eya2 promotes cell cycle progression by regulating DNA damage response
during vertebrate limb regeneration, eLIFE, 9:e51217
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Kriegman, S., Nasab, A. M., Shah, D., Steele, H., Branin, G., Levin, M., Bongard, J. and Kramer-Bottiglio, R. (2020),
Scalable sim-to-real transfer of soft robot designs,
Proceedings of the 3rd IEEE International Conference on Soft Robotics (RoboSoft 2020), p. 359-366
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Fields, C., and Levin, M., (2020),
Does regeneration recapitulate phylogeny?, Communicative and Integrative Biology, 13(1): 27-38
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Herrera-Rincon, C., Pare, J-F., Martyniuk, C. J., Jannetty, S. K., Harrison C., Fischer, A., Dinis, A., Keshari, V., Novak, R., and Levin, M., (2020),
An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity, NPJ Regenerative Medicine, 5:2
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Srivastava, P., Kane, A., Harrison, C., and Levin, M., (2020), A Meta-Analysis of Bioelectric Data in Cancer,
Embryogenesis, and Regeneration, Bioelectricity, in press
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McMillen, P., Novak, R., and Levin, M., (2020), Toward Decoding Bioelectric Events in
Xenopus Embryogenesis: New Methodology for Tracking Interplay Between Calcium and Resting Potentials
In Vivo, Journal of Molecular Biology, 432: 605-620 [cover]
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Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Wade, C. M., Chiba, S., Jackson, D. J., Levin, M., and Blaxter, M. L., (2020),
Formin, an opinion, Development, 147: dev187427
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Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D. L., (2020), Optogenetically induced cellular
habituation in non-neuronal cells, PLOS One, 15(1):e0227230
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Tung, A., and Levin, M., (2020), Extra-genomic instructive influences
in morphogenesis: A review of external signals that regulate growth and form,
Developmental Biology, 461: 1-12 [cover]
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Kriegman, S., Blackiston, D., Levin, M., and Bongard, J., (2020),
A scalable pipeline for designing reconfigurable organisms,
Proceedings of the National Academy of Sciences of the United States,
doi/10.1073/pnas.1910837117
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Kamaldinov, T., Erndt-Marino, J., Levin, M., Kaplan, D. L., and Hahn, M. S., (2020), Assessment of Enrichment of
Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials, Bioelectricity, 2(1): 21-32
PDF
Healy, D., Faber, C., Lapalme, J., and Levin, M., (2020), Post-SSRI Sexual Dysfunction:
a bioelectric mechanism?, Bioelectricity, 2(1): 7-13
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Levin, M., (2020), The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation, BioEssays, 42: 1900146
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Cervera, J., Meseguer, S., Levin, M., and Mafe, S., (2020), Bioelectrical model of head-tail patterning
based on cell ion channels and intercellular gap junctions, Bioelectrochemistry, 132: 107410
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Fields, C., Bischof, J., and Levin, M., (2020), Morphological Coordination:
A Common Ancestral Function Unifying Neural and Non-Neural Signaling,
Physiology, 35: 16-30
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2019
Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M. J., (2019),
Defined extracellular ionic solutions to study and manipulate the cellular
resting membrane potential, Biology Open, 9(1): bio048553
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Levin, M., Selberg, J., and Rolandi, M., (2019), Endogenous Bioelectrics in Development,
Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine,
iScience, 22: 519–533
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Manicka, S., and Levin, M., (2019), Modeling somatic computation with non-neural bioelectric networks,
Scientific Reports 9: 18612, doi:10.1038/s41598-019-54859-8
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Finkelstein J., McLaughlin K., Levin M. (2019), Interdisciplinary Approach
Needed to Crack Morphogenesis, The Scientist, December 2019
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Levin, M., (2019), The Computational Boundary of a 'Self': Developmental Bioelectricity
Drives Multicellularity and Scale-Free Cognition, Frontiers in Psychology, 10:2688, doi: 10.3389/fpsyg.2019.02688
PDF
Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J.,
Davidian, D., Morokuma, J., and Levin, M., (2019),
Regenerative Adaptation To Electrochemical Perturbation In Planaria: A Molecular Analysis
Of Physiological Plasticity, iScience, 22: 147-165
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Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J., (2019), L-type voltage-gated Ca2+
channel CaV1.2 regulates chondrogenesis during limb development, Proceedings of the
National Academy of Sciences of the United States, 116(43): 21592-21601
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Grasman, J., Williams, M., Razis, C., Bonzanni, M., Golding, A., Cairns, D. M., Levin, M., and Kaplan, D. L., (2019),
Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation,
ACS Biomater. Sci. Eng., 5(10): 5327-5336
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Levin, S., and Levin, M., (2019), Managing Ideas, People, and Projects:
Organizational Tools and Strategies for Researchers, iScience, 20: 278–291
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Payne, S. L., Levin, M., and Oudin, M. J., (2019), Bioelectric control of metastasis in
solid tumors, Bioelectricity, 1(3): 114-130
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Fields, C., and Levin, M., (2019), Somatic Multicellularity as a Satisficing
Solution to the Prediction-Error Minimization Problem,
Communicative & Integrative Biology, 12(1): 119-132
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Punjiya, M., Nehad, H. R., Mathews, J., Levin, M., Sonkusale, S., (2019), A flow through device for
simultaneous dielectrophoretic cell trapping and AC electroporation,
Scientific Reports, 9:11988
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Whited, J., and Levin, M., (2019), Bioelectrical controls of morphogenesis: from ancient mechanisms of
cell coordination to biomedical opportunities, Current Opinion in Genetics & Development, 57: 61-69 [cover]
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Levin, M., and Martinez-Arias, A., (2019), Reverse-engineering growth and form in Heidelberg,
Development, 146: dev177261
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Kriegman, S., Walker, S., Shah, D. S., Kramer-Bottiglio, R., and Bongard, J., (2019), Automated Shapeshifting
for Function Recovery in Damaged Robots, Proceedings of Robotics: Science and Systems XV: 28
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Cervera, C., Pai, V. P., Levin, M., and Mafe, S., (2019),
From non-excitable single-cell to multicellular bioelectrical states
supported by ion channels and gap junction proteins: electrical potentials
as distributed controllers, Progress in Biophysics and Molecular Biology, 149: 39-53
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Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D., (2019),
On the generalization of habituation: how discrete biological systems
respond to repetitive stimuli, BioEssays, 41(7): 1900028
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Kuchling, F., Friston, K., Georgiev, G., and Levin, M., (2019), Morphogenesis as
Bayesian Inference: a Variational Approach to Pattern Formation and Control in
Complex Biological Systems, Physics of Life Reviews, in press
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Beane, W. S., Adams, D. S., Morokuma, J., and Levin, M., (2019), Live Imaging of Intracellular pH
in Planarians Using the Ratiometric Fluorescent Dye SNARF-5F-AM,
Biology Methods and Protocols, 4(1): bpz005
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Cervera, J., Manzanares, J. A., Mafe, S., and Levin, M., (2019),
Synchronization of Bioelectric Oscillations in Networks of
Nonexcitable Cells: From Single-Cell to Multicellular States,
Journal of Physical Chemistry B, 123: 3924-3934 [cover]
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Manicka, S., and Levin, M., (2019), The Cognitive Lens: a primer on conceptual tools for analysing
information processing in developmental and regenerative morphogenesis, Philosophical Transactions
of the Royal Society B, 374: 20180369
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Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M., (2019), Neural control of body-plan axis in regenerating planaria,
PLOS Computational Biology, 15(4): e1006904
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Bizzari, M., Brash, D., Briscoe, J., Grieneisen, V., Stern, C. D., and Levin, M., (2019), A Call for a
Better Understanding of Causation in Cell Biology, Nature Reviews Molecular Cell Biology, 20(5): 261-262
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Sundelacruz, S., Moody, A. T., Levin, M., and Kaplan, D., (2019), Membrane potential depolarization
alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells,
Bioelectricity, 1(1): 56-66
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Hammelman, J., Siegelmann, H., Manicka, S., and Levin, M., (2019),
Toward modeling regeneration via adaptable echo state networks,
in A. Adamatzky, S. Akl, and G. Sirakoulis (Eds.), From parallel to emergent computing,
Chapter 6, pages 117-133, CRC Press: Boca Raton, FL
Berard, A., Levin, M., Sadler, T., and Healy, D., (2019),
Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Major Malformations:
The Importance of Serotonin for Embryonic Development and the Effect of Serotonin Inhibition
on the Occurrence of Malformations, Bioelectricity, 1(1): 18-29
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Ferenc, N. N., and Levin, M., (2019), Effects of ivermectin exposure on regeneration of
D. dorotocephala planaria: exploiting human-approved ion channel drugs as morphoceuticals,
Macromolecular Bioscience, 19(3): 1800237 [cover]
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Levin, M., Pietak, A., and Bischof, J., (2019), Planarian Regeneration as a Model of Anatomical
Homeostasis: Recent Progress in Biophysical and Computational Approaches, Seminars in Cell and Developmental Biology, 87: 125-144
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Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M., (2019),
The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity,
Biophysical Journal, 116(5): 948-961
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Churchill, C. D. M., Winter, P., Tuszynski, J. A., and Levin, M., (2019), EDEn – Electroceutical Design
Environment: Ion Channel Tissue Expression Database with Small Molecule Modulators, iScience,
11:42-56
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2018
Fields, C., and Levin, M., (2018), Multiscale Memory And Bioelectric Error Correction
In The Cytoplasm-Cytoskeleton-Membrane System, Wiley Interdisciplinary Reviews:
Systems Biology and Medicine, 10(2): e1410 [cover]
PDF
Minh-Thai, T. N., Aryal, J., Samarasinghe, S., and Levin, M., (2018), A Computational Framework
for Autonomous Self-repair Systems, in Mitrovic, T., Xue, B., and Li, X. (Eds.), AI 2018:
Advances in Artificial Intelligence, p153-159. Lecture Notes in Computer Science, vol 11320. Springer, Cham
PDF
Adams, D. S., and Levin, M., (2018),
Ahead of the Curve: hidden breakthroughs in the biosciences,
Vol. 2, IOP Publishing Ltd: Bristol [cover]
Link
Lee, F. J., Williams, K. B., Levin, M., and Wolfe, B. E., (2018), The bacterial metabolite indole
inhibits regeneration of the planarian flatwork Dugesia japonica, iScience, 10: 135-148
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Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J.,
Carabello, H., Kaplan, D. L., and Levin, M., (2018), Brief Local Application of Progesterone via a Wearable
Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb, Cell Reports, 25(6): 1593-1609
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Kamm, R. D., Bashir, R., Arora, N., Dar, R. D., Gilette, M. U., Griffith, L. G., Kemp, M. L., Kinlaw, K., Levin, M., Martin,
A. C., McDevitt, T. C., Nerem, R. M., Powers, M. J., Saif, T. A., Sharpe, J., Takayama, S., Takeuchi, S., Weiss, R.,
Ye, K., Yevick, H. G., and Zaman, M. H., (2018), Perspective: the promise of multi-cellular engineered living systems,
APL Bioengineering, 2(4): 040901
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Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L., (2018),
Ivermectin promotes peripheral nerve regeneration during wound healing,
ACS Omega, 3(10): 12392-12402
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Hart, M. R., Anderson, D. J., Porter, C. C., Neff, T., Levin, M., Horwitz, M. S., (2018),
Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations, PLoS Genetics, 14(9): 1007642
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Busse, S. M., McMillen, P. T., and Levin, M., (2018),
Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals,
Development, 145(19). pii: dev164210
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Moore, D. G., Walker, S. I., and Levin, M., (2018),
Pattern Regeneration in Coupled Networks, in T. Ikegami, N. Virgo, O. Witkowski,
M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 204-205.
PDF
Ferreira, G. B. S., Scheutz, M., and Levin, M., (2018),
Modeling Cell Migration in a Simulated Bioelectrical Signaling Network for Anatomical Regeneration,
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life.
MIT Press: Tokyo, p. 194-201.
PDF
Brodsky, M., and Levin, M., (2018),
From Physics to Pattern: Uncovering Pattern Formation in Tissue Electrophysiology,
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life.
MIT Press: Tokyo, p. 351-358.
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Moore, D. G., Valentini, G., Walker, S. I., and Levin, M., (2018),
Inform: Efficient Information-Theoretic Analysis of Collective Behaviors, Frontiers in Robotics and AI,
5: 60
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Pezzulo, G., and Levin, M., (2018), Embodying Markov blankets. Comment on 'Answering Schrödinger's question:
A free-energy formulation' by Maxwell James Désormeau Ramstead et al., Physics of Life Reviews, 24: 32-36
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Cervera, J., Pietak, A., Levin, M., and Mafe, S., (2018), Bioelectrical coupling in multicellular
domains regulated by gap junctions: a conceptual approach, Bioelectrochemistry, 123: 45-61 [cover]
PDF
Pietak, A., and Levin, M., (2018), Bioelectrical control of positional information in
development and regeneration: a review of conceptual and computational advances,
Progress in Biophysics and Molecular Biology, 137: 52-68
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Mathews, J., and Levin, M., (2018), The Body Electric 2.0: Recent Advances in Developmental
Bioelectricity for Regenerative and Synthetic Bioengineering,
Current Opinion in Biotechnology, 52: 134-144
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Monsoro-Burq, A. H., and Levin, M., (2018), Avian models and the study of invariant asymmetry:
how the chicken and the egg taught us to tell right from left, International Journal of
Developmental Biology, 62(1-3): 63-77
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Fields, C., and Levin, M., (2018), Are planaria individuals? What regenerative
biology is telling us about the nature of multicellularity, Evolutionary Biology,
45(3): 237–247
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Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M., (2018),
HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns,
Nature Communications, 9(1): 998
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Sullivan, K. G., and Levin, M., (2018), Inverse Drug Screening of Bioelectric Signaling and Neurotransmitter Roles:
Illustrated Using a Xenopus Tail Regeneration Assay, Cold Spring Harbor Protocols, 2018(3): pdb.prot099937
PDF
Levin, M., and Martyniuk, C. J., (2018), The bioelectric code: An ancient computational medium
for dynamic control of growth and form, BioSystems, 164: 76-93
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Cairns, D. M., Boorgu, D. S. S. K., Levin, M., and Kaplan, D. L., (2018),
Niclosamide rescues microcephaly in a humanized in vivo model of
Zika infection using human induced neural stem cells, Biology Open, 7(1): bio031807
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Herrera-Rincon, C., and Levin, M., (2018), Booting up the organism during
development: pre-behavioral functions of the vertebrate brain in guiding body morphogenesis,
Communicative & Integrative Biology, 11(1): e1433440
PDF [cover]
Vallverdu, J., Castro, O., Mayne, R., Talanov, M., Levin, M., Baluska, F., Gunji, Y., Dussutour,
A., Zenil, H., and Adamatzky, A., (2018), Slime mould: the fundamental mechanisms
of biological cognition, BioSystems, 165: 57-70
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Ferreira, G. B. S., Scheutz, M., and Levin, M., (2018), Introducing Simulated Stem Cells
into a Bio-Inspired Cell-Cell Communication Mechanism for Structure Regeneration,
Proceedings of the 2017 IEEE Symposium Series on Computational Intelligence (SSCI), p. 2778-2785
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2017
Tuszynski, J., Tilli, T. M., and Levin, M., (2017), Ion channel and neurotransmitter
modulators as electroceutical approaches to the control of cancer,
Current Pharmaceutical Design, 23(32): 4827-4841
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Herrera-Rincon, C., Pai, V. P., Moran, K. M., Lemire, J. M., and Levin, M., (2017),
The brain is required for normal muscle and nerve patterning during early
Xenopus development, Nature Communications, 8(1): 587
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Pitcairn, E., Harris, H., Epiney, J., Pai, V. P., Lemire, J. M., Ye, B., Shi, N-Q., Levin, M., and McLaughlin, K. A., (2017),
Coordinating heart morphogenesis: A novel role for Hyperpolarization-activated cyclic nucleotidegated
(HCN) channels during cardiogenesis in Xenopus laevis, Communicative & Integrative Biology,
10(3): e1309488 [cover]
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Pietak, A. M., and Levin, M., (2017), Bioelectric Gene and
Reaction Networks: Computational Modeling of Genetic, Biochemical, and Bioelectrical Dynamics
in Pattern Regulation, J. Royal Society Interface, 14(134): 20170425 [cover]
PDF
McLaughlin, K. A., and Levin, M., (2017), Bioelectric Signaling in Regeneration:
Mechanisms of Ionic Controls of Growth and Form, Developmental Biology, 433(2): 177–189
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Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Pare, J-F., Shi, N-Q., McLaughlin, K. A., and Levin, M., (2017),
HCN4 Ion Channel Function is Required for Early Events that Regulate Anatomical Left-Right Patterning in
a Nodal- and Lefty Asymmetric gene Expression-Independent Manner, Biology Open, 6(10): 1445-1457
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Moore, D., Walker, S., and Levin, M., (2017), Cancer as a Disorder of Patterning Information:
computational and biophysical perspectives on the cancer problem, Convergent Science Physical Oncology, 3(4): 043001
PDF
Bryant, D. M., Sousounis, K., Farkas, J. E., Bryant, S., Thao, N., Guzikowski, A. R., Monaghan, J. R.,
Levin, M., and Whited, J. L., (2017), Repeated removal of developing limb buds permanently
reduces appendage size in the highly-regenerative axolotl,
Developmental Biology, 424(1): 1-9 [cover]
PDF
Adams, D. S., Tseng. A-S., and Levin, M., (2017), Using optogenetics in vivo to stimulate regeneration,
in K. Appasani (Ed.), Optogenetics: From Neuronal Function to Mapping and Disease Biology,
Cambridge University Press: Cambridge, UK, p. 66-76
Ferreira, G. B., Scheutz, M., and Levin, M., (2017), Investigating the Effects of Noise on
a Cell-to-Cell Communication Mechanism for Structure Regeneration, in
C. Knibbe, D. Parsons, D. Misevic, J. Rouzaud-Cornaba, N. Bredèche, S. Hassas, O. Simonin, and H. Soula. (Eds.),
Proceedings of the 14th European Conference on Artificial Life (ECAL 2017), Lyon, France
PDF
Zahn, N., Levin, M., and Adams, D. S., (2017), The Zahn Drawings: new illustrations of
Xenopus embryo and tadpole stages for studies of craniofacial development, Development, 144(15): 2708-2713 [cover]
PDF
Dungan, J., Mathews, J., Levin, M., and Koomson, V., (2017),
Microfluidic Platform to Study Intercellular Connectivity Through on-Chip
Electrical Impedance Measurement, IEEE 60th International Midwest Symposium on Circuits and Systems,
Boston, MA, p.56-69 doi: 10.1109/MWSCAS.2017.8052859
PDF
Pare, J-F., Martyniuk, C. J., and Levin, M., (2017),
Bioelectric regulation of innate immune system function in regenerating
and intact Xenopus laevis, npj Regenerative Medicine, 2:15
PDF
Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M., (2017),
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous
Bioelectric Gradients, Biophysical Journal, 112(10): 2231-2243 [cover]
PDF
Levin, M., Morokuma, J., and Finkelstein, J, (2017), Space travel has effects on
planarian regeneration that cannot be explained by a null hypothesis,Regeneration,
4(4): 156-158
Morokuma, J., Durant, F. R., Williams, K. B., Finkelstein, J. M., Blackiston,
D. J., Clements, T., Reed, D. W., Roberts, M., Jain, M., Kimel, K., Trayger, S. A.,
Wolfe, B. E., and Levin, M., (2017), Planarian regeneration in space: persistent anatomical,
behavioral, and bacteriological changes induced by space travel, Regeneration, 4(2): 85-102 [cover]
PDF
Mathews, J., and Levin, M., (2017), Gap Junctional Signaling in Pattern Regulation:
physiological network connectivity instructs growth and form, Developmental Neurobiology, 77(5): 643-673
PDF
Levin, M., Pezzulo, G., and Finkelstein, J. M., (2017), Endogenous Bioelectric
Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form,
Annual Review of Biomedical Engineering, 19: 353-87
PDF
Thurber, A. E., Nelson, M., Frost, C. L., Levin, M., Brackenbury, W. J., and Kaplan, D. L., (2017),
IK channel activation increases tumor growth and induces differential behavioral
responses in two breast epithelial cell lines, Oncotarget, 8(26): 42382-42397
PDF
Blackiston, D., Vien, K., and Levin, M., (2017), Serotonergic stimulation
induces nerve growth and promotes visual learning via posterior eye grafts in
a vertebrate model of induced sensory plasticity, npj Regenerative Medicine, 2:8
PDF
Lobo, D., Lobikin, M., and Levin, M., (2017), Discovering novel phenotypes with automatically
inferred dynamic models: partial melanocyte conversion in Xenopus,
Scientific Reports, 7: 41339
PDF
Blackiston, D. J., and Levin, M., (2017), Reversals of bodies, brains, and behavior:
quantitative analysis of laterality and its disturbance in model species,
in L. J. Rogers and G. Vallortigara (Eds.), Lateralized Brain Functions: Methods in Human and Non-human Species,
"Neuromethods", W. Walz (Ed.), 122: 667-694
PDF
Garcia-Quismondo, M., Levin, M., and Lobo, D., (2017), Modeling regenerative processes with
Membrane Computing, Information Sciences, 381: 229-249
PDF
2016
Levin, M., and Adams, D. S., (2016), Ahead of the Curve: Hidden Breakthroughs in the Biosciences,
Vol. 1, IOP Publishing: Bristol, UK [cover]
Levin, M., Klar, A. J. S., Ramsdell, A., (2016), Introduction to provocative
questions in Left-Right asymmetry, Philosophical Transactions B, 371: 20150399 [cover]
PDF
McDowell, G., Rajadurai, S., and Levin, M., (2016), From cytoskeletal dynamics to organ asymmetry:
a nonlinear, regulative pathway underlies left-right patterning,
Philosophical Transactions B, 371: 20150409 [cover]
PDF
Pezzulo, G., and Levin, M., (2016), Top-down Models in biology: Explanation and control
of complex living systems above the molecular level,
Journal of the Royal Society Interface, 13: 20160555
PDF
Herrera-Rincon, C., Guay, J., and Levin, M., (2016), Bioelectrical coordination
of cell activity toward anatomical target states: an engineering perspective on regeneration,
Chapter 4 in D. Gardiner (Ed.), Regenerative Engineering and Developmental Biology: Principles and Applications,
CRC Press: Boca Raton, FL, p. 55-112
Link
Neuhof, M., Levin, M., and Rechavi, O., (2016), Vertically and horizontally-transmitted memories –
the fading boundaries between regeneration and inheritance in planaria, Biology Open, 5, 1177-1188
[cover]
PDF
Ferreira, G., Smiley, M., Scheutz, M., and Levin, M., (2016), Dynamic structure discovery and repair for
3D cell assemblages, Proceedings of the Fifteenth International Conference on the Synthesis
and Simulation of Living Systems (ALIFEXV), p. 352-359
PDF
Serlin, Z., Rife, J., and Levin, M., (2016), A Level Set Approach to Simulating Xenopus laevis Tail Regeneration,
Proceedings of the Artificial Life Conference 2016, p. 528-535
PDF
Pietak, A., and Levin, M., (2016), Exploring Instructive Physiological Signaling with
the Bioelectric Tissue Simulation Engine (BETSE), Frontiers in
Bioengineering and Biotechnology, 4(55): doi 10.3389/fbioe.2016.00055
PDF
Baluska, F., and Levin, M., (2016), On Having No Head: Cognition throughout Biological Systems,
Frontiers in Psychology, 7: 902, doi: 10.3389/fpsyg.2016.00902
PDF
Golding, A., Guay, J. A., Herrera-Rincon, C., Levin, M., and Kaplan, D. L., (2016),
A Tunable Silk Hydrogel Device for Studying Limb Regeneration in Adult Xenopus
laevis, PLoS One 11, e0155618
PDF
Sullivan, K. G., Emmons-Bell, M., and Levin, M., (2016), Physiological Inputs Regulate
Species-Specific Anatomy During Embryogenesis And Regeneration,
Communicative and Integrative Biology, 9:4, e1192733
PDF
Lobo, D., Morokuma, J., and Levin, M., (2016), Computational discovery and in vivo validation of
hnf4 as a regulatory gene in planarian re-generation,
Bioinformatics, 32(17): 2681-2685
PDF
De, Abhishek, Chakravarthy, V. Srinivasa , and Levin, M., (2016), A Computational Model of Planarian
Regeneration, International Journal of Parallel, Emergent, and Distributed Systems, 32(4): 331-347
PDF
Rothman, G., Blackiston, D., and Levin, M., (2016),
Color and intensity discrimination in Xenopus laevis tadpoles,
Animal Cognition, 19:911-919
PDF
Edelstein, L., Fuxe, K., Levin, M., Popescu, B., and Smythies, J., (2016),
Telocytes in their context with other intercellular communication agents,
Seminars in Cell and Developmental Biology, 55:9–13
PDF
Davison A., McDowell G. S., Holden, J. M., Johnson H. F., Koutsovoulos G. D.,
Liu M. M., Hulpiau P., Van Roy F., Wade C. W., Banerjee R., Yang F., Chiba S.,
Davey J. W., Jackson, D. J., Levin M., and Blaxter, M. L., (2016), Formin Is
Associated with Left-Right Asymmetry in the Pond Snail and the Frog,
Current Biology, 26(5): 654-60 [cover]
PDF
Durant, F., Lobo, D., Hammelman, J., and Levin, M., (2016), Physiological controls of
large-scale patterning in planarian regeneration: a molecular and computational
perspective on growth and form, Regeneration, 3(2): 78-102
PDF [cover]
Sullivan, K. G., and Levin, M., (2016), Neurotransmitter signaling pathways required
for normal development in Xenopus laevis embryos: a pharmacological survey screen,
Journal of Anatomy, 229: 483-502 [cover]
PDF
Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M., (2016),
Use of genetically encoded, light-gated ion translocators to control tumorigenesis,
Oncotarget, 7(15): 19575-19588
PDF
Adams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva,
V., Yelick, P. C., Devitt-Lee, A.,
Pare, J-F., and Michael Levin, (2016), Bioelectric signaling via potassium channels: a mechanism
for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome, Journal of Physiology, 12: 3245-3270 [cover]
PDF
McDowell, G. S., Lemire, J. M., Pare, J-F., Cammarata, G., Lowery, L. A., and Levin, M., (2016),
Conserved roles for cytoskeletal components in determining laterality,
Integrative Biology, 8: 267-286. DOI: 10.1039/C5IB00281H [cover]
PDF
Li, C., Levin, M., and Kaplan, D., (2016), Bioelectric modulation of macrophage polarization,
Scientific Reports, 6:21044, doi:10.1038/srep21044
PDF
Dimonte, A., Adamatzky, A., Erokhin, V., (2016), On chirality of slime mould,
BioSystems, 140: 23-27
PDF
Lobo, D., Hammelman, J., and Levin, M., (2016), MoCha: molecular characterization of
unknown pathways, Journal of Computational Biology, 23(4): 291-297
PDF
Whiting, J. G. H., Jones, J., Bull, L., Levin, M., and Adamatzky, A., (2016), Towards a
physarum learning chip, Scientific Reports, 6:19948 (1-14)
PDF
Lobo, D., and Levin, M., (2016), Computing a worm: reverse-engineering planarian regeneration,
Advances in Unconventional Computing, Andrew Adamatzky ed., Vol. 2, Springer, p. 637-654
Hammelman, J., Lobo, D., and Levin, M., (2016),
Artificial neural networks as models
of robustness in development and regeneration: stability of memory during morphological
remodeling, in Artificial Neural Network (ANN) Modeling, S. Shanmuganathan and S. Samarasinghe (Eds.) , p. 45-65
PDF
2015
Sundelacruz, S., Levin M., and Kaplan, D. L., (2015),
Comparison of the depolarization response of human mesenchymal
stem cells from different donors, Scientific Reports, 5: 18279 (doi: 10.1038/srep18279)
PDF
Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V.,
Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M.,
(2015), Gap junctional blockade stochastically induces different
species-specific head anatomies in genetically wild-type Girardia
dorotocephala flatworms, International Journal of Molecular Sciences, 16: 27865–27896 [cover]
PDF
Pezzulo, G., and Levin, M., (2015), Re-membering the body: applications of computational
neuroscience to the top-down control of regeneration of limbs and other complex organs,
Integrative Biology, 7: 1487-1517 [cover]
PDF
Pang, J., Ozkucur, N., Ren, M., Kaplan, D. L., Levin, M., and Miller, E. L., (2015),
Automatic neuron segmentation and neural network analysis
method for phase contrast microscopy images, Biomedical Optics Express, 6(11) 4395-4416
PDF
Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M., (2015),
Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network
for stochastic all-or-none hyperpigmentation, Science Signaling, 8(397): ra99
PDF
Law, R., and Levin, M., (2015), Bioelectric memory: modeling resting potential
bistability in amphibian embryos and mammalian cells,
Theoretical Biology and
Medical Modelling, 12: (1): 22
PDF
Pai, V. P., Martyniuk, C. J., Echeverri, K., Sundelacruz, S., Kaplan, D. L.,
and Levin, M., (2015), Genome-wide analysis reveals conserved transcriptional
responses downstream of resting potential change in Xenopus embryos, axolotl
regeneration, and human mesenchymal cell differentiation, Regeneration, 3(1): 3-25
PDF
Schatzberg, D., Lawtn, M., Hadyniak S. E., Ross E. J., Carney T., Beane W. S., Levin, M.,
and Bradham, C. A., (2015), H+/K+-ATPase activity is required for biomineralization
in sea urchin embryos, Developmental Biology, 406(2): 259-270
PDF
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., Volpert, V., (2015),
Target morphology and cell memory: a model of regenerative pattern formation,
Neural Regeneration Research, 10(12): 1901-1905 [cover]
PDF
Blackiston, D. J., Shomrat, T., and Levin, M., (2015), The Stability of Memories
During Brain Remodeling: a Perspective, Communicative and Integrative Biology, 8(5): e1073424 [cover]
PDF
Pai, V. P., Lemire J. M., Chen Y., Lin G., and Levin M., (2015), Local and long-range
endogenous resting potential gradients antagonistically regulate apoptosis and proliferation
in the embryonic CNS, International Journal of Developmental Biology, 59: 327-340 (2015) [cover]
PDF
Lobikin, M., Pare, J-F., Kaplan, D. L., and Levin, M., (2015),
Selective Depolarization Of Transmembrane Potential Alters Muscle
Patterning And Muscle Cell Localization In Embryonic Xenopus Laevis,
International Journal of Developmental Biology, 59: 303-311 (2015) [cover]
PDF
Lobo, D., and Levin, M., (2015), Inferring regulatory networks from experimental morphological phenotypes:
a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
PDF
Tosenberger, A., Bessonov, N., Levin, M., Reinberg, N., Volpert, V., Morozova, N., (2015),
A conceptual model of morphogenesis and regeneration, Acta Biotheoretica, 63: 283-294
PDF
Friston, K., Levin, M., Sengupta B., and Pezzulo, G., (2015), 'Knowing one's place' a free energy approach
to pattern regulation, Journal of the Royal Society Interface, 12: 20141383
PDF
Pai, V., Lemire, J. M., Pare, J-F., Lin, G., Chen, Y., and Levin, M., (2015), Endogenous gradients
of resting potential instructively pattern embryonic neural tissue via Notch signaling
and regulation of proliferation, Journal of Neuroscience, 35(10): 4366-4385
PDF
Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I.,
Miller, E., Levin, M., and Kaplan, D. L., (2015), Membrane potential depolarization causes alterations
in neuron arrangement and connectivity in cocultures,
Brain and Behavior, 5(1): 24-38
PDF
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V., (2015),
On a model of pattern recognition based on cell memory, PLoS One, 10(2): e0118091
PDF
Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and
Levin, M., (2015), A novel method for inducing nerve
growth via modulation of host resting potential,
Neurotherapeutics, 12: 170-184
PDF
Chernet, B. T., Fields, C., and Levin, M., (2015), Long-range gap junctional signaling
controls oncogene-mediated tumorigenesis in Xenopus laevis embryos, Frontiers in Physiology,
5(519); 1-15, doi: 10.3389/fphys.2014.00519
PDF
2014
Levin, M., (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior
and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25(24): 3835-3850
PDF
Jewhurst, K., Levin, M., and McLaughlin, K. A., (2014),
Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos,
Journal of Cell Death, 7: 25-31
PDF
Adams, D.S., Lemire, J. M., Kramer, R. H., and Levin, M., (2014),
Optogenetics in developmental biology: using light to control ion flux-dependent
signals in Xenopus embryos, International Journal of Developmental Biology,
58(10-12): 851-861
PDF
Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. M., and Levin, M., (2014),
Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling
and gap junctions, International Journal of Developmental Biology, 58(10-12): 799-809
PDF
Zhu, F., Skommer, J., Huang, Y., Akagi, J., Adams, D. S., Levin, M., Hall, C. J.,
Crosier, P. S., and Wlodkowic, D., (2014), Fishing on chips: up-and-coming
technological advances in analysis of zebrafish and Xenopus embryos, Cytometry A,
85A: 921-932
PDF
Lobo, D., Feldman, E. B., Shah, M., Malone, T. J., and Levin,
M., (2014), Limbform: a functional ontology-based
database of limb regeneration experiments,
Bioinformatics, 30(24): 3598-3600
PDF
Lan J. Y., Williams C., Levin M., and Black L. D. III, (2014),
Depolarization of Cellular Resting Membrane Potential Promotes Neonatal
Cardiomyocyte Proliferation In Vitro, Cellular and Molecular Bioengineering,
7(3): 432-445
PDF
Mustard, J., and Levin, M., (2014), Bioelectrical mechanisms for programming
growth and form: taming physiological networks for soft body robotics, Soft Robotics, 1(3): 169-191
PDF
Lobo, D., Feldman, E. B., Shah, M., Malone, T., and Levin, M., (2014),
A bioinformatics expert system linking functional data to
anatomical outcomes in limb regeneration, Regeneration,
1(2): 37-56
PDF
Budnikova, M., Habig, J. W., Cornia, N., Levin. M., Lobo, D., and Andersen,
T., (2014), Design of a flexible component gathering algorithm for
converting cell-based models to graph representations for use in
evolutionary search, BMC Bioinformatics, 15:
178, doi: 10.1002/reg2.13
PDF
Chernet, B., and Levin, M., (2014), Transmembrane voltage potential of
somatic cells controls oncogene-mediated tumorigenesis at long-range,
Oncotarget, 5(10): 3287-3306 [cover]
PDF
Hernandez-Diaz S., and Levin, M., (2014), Alteration of bioelectrically-controlled processes
in the embryo: a teratogenic mechanism for anticonvulsants,
Reproductive Toxicology, 47: 111-114
PDF
Pai, V., and Levin, M., (2014), Bioelectric controls of stem cell function,
Chapter 5 in F. Calegari and C. Waskow (Eds.), Stem Cells: From Basic Research to Therapy, Volume 1,
CRC Press: Boca Raton, FL, p. 106-145
Amazon book
Levin, M., (2014), Endogenous bioelectrical networks
store non-genetic patterning information during development and
regeneration, Journal of Physiology, 592(11): 2295–2305
PDF
Lobo, D., Solano, M., Bubenik, G. A., and Levin, M., (2014), A linear-encoding model
explains the variability of the target morphology in regeneration,
Journal of the Royal Society Interface, 11(92): 20130918
PDF
Lobikin, M., and Levin, M., (2014), Endogenous bioelectric
cues as morphogenetic signals in vivo, Chapter 15 in
D. Fels, M. Cifra, and F. Scholkmann (Eds), Fields of the Cell,
Research Signpost: Kerala, India p. 283-302
PDF
2013
Vandenberg, L. N., Lemire, J. M, and Levin, M., (2013), It's Never too Early
to get it Right: A Conserved Role for the Cytoskeleton in Left-Right Asymmetry,
Communicative & Integrative Biology, 6(6): e27155
PDF
Rea, A. C., Vandenberg, L. N., Ball, R. E., Snouffer, A. A., Hudson, A. G., Zhu, Y., McLain, D. E.,
Johnston, L. L., Lauderdale J. D., Levin, M., and Dore, T. M.,
(2013), Light-activated serotonin for exploring its action in
biological systems, Chemistry & Biology, 20(12): 1536–1546
PDF
Sundelacruz, S., Li, C., Choi, Y. J., Levin, M., and Kaplan, D. L., (2013), Bioelectric
modulation of wound healing in a 3D in vitro model of tissue-engineered bone,
Biomaterials, 34(28): 6695-705
PDF
Sundelacruz, S., Levin, M., and Kaplan, D. L., (2013), Depolarization Alters
Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells,
Tissue Engineering Part A, 19 (17-18): 1889-1908
PDF
Chernet, B., and Levin, M., (2013), Endogenous voltage potentials and
the microenvironment: bioelectric signals that reveal, induce, and normalize cancer,
Journal of Clinical and Experimental Oncology, S1: doi:10.4172/2324-9110.S1-002
[cover]
PDF
Levin, M., (2013), Reprogramming cells and tissue
patterning via bioelectrical pathways: molecular mechanisms
and biomedical opportunities, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(6): 657-676
PDF
Shomrat, T., and Levin, M., (2013), An
automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration,
Journal of Experimental Biology, 216(20): 3799-3810
PDF |
Overview
Levin, M., (2013), Bioelectrical signaling has rich history, Physics Today, 66(9): 11
Blackiston, D. J., and Levin, M., (2013), Inversion
of left-right asymmetry alters performance of Xenopus
tadpoles in nonlateralized cognitive tasks, Animal Behaviour, 86(2): 459-466
PDF
Vandenberg, L. N., and Levin, M., (2013), A unified model
for left-right asymmetry? Comparison and synthesis of molecular models
of laterality, Developmental Biology, 379(1): 1-15
[cover]
PDF
Lobo, D., Malone, T. J., and Levin, M., (2013), Towards
a bioinformatics of patterning: a computational approach to
understanding regulative morphogenesis, Biology Open, 2(2): 156-169 [cover]
PDF
Vandenberg, L. N., Morrie, R. D., Seebohm, G., Lemire, J. M.,
and Levin, M., (2013), Rab GTPases are required for early
orientation of the left-right axis in Xenopus,
Mechanisms of Development, 130(4-5): 254-271 [cover]
PDF
Adams, D. S., and Levin, M., (2013), Endogenous Voltage Gradients as
Mediators of Cell-Cell Communication: Strategies for Investigating
Bioelectrical Signals During Pattern Formation, Cell and Tissue
Research, 352(1):95-122 [cover]
PDF
Blackiston, D. J., and Levin, M., (2013), Ectopic eyes
outside the head in Xenopus tadpoles provide sensory data for
light-mediated learning, Journal of Experimental
Biology, 216(6): 1031-1040
PDF
Lobo, D., Malone, T.J., and Levin, M., (2013),
Planform: an application and database of graph-encoded
planarian regenerative experiments, Bioinformatics,
29(8): 1098-1100
PDF
Koustubhan, P., Kaplan, D., and Levin, M., (2013),
Humane anesthesia and pain management in amphibian limb surgery
of Rana pipiens, Cold Spring Harbor Protocols, 2013(2): 149 [cover]
PDF
Chernet, B. T., and Levin, M., (2013), Transmembrane voltage
potential is an essential cellular parameter for the detection
and control of tumor development,
Disease Models & Mechanisms, 6(3): 595-607
PDF
Tseng, A-S., and Levin, M., (2013), Cracking the
bioelectric code: probing endogenous ionic controls of pattern
formation, Communicative & Integrative Biology,
6(1): e22595 [cover]
PDF
Adams, D. S., Tseng, A-S. and M. Levin, (2013), Light-activation of the Archaerhodopsin
H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level
controls in vivo, Biology Open, 2(3): 306-313
PDF
Vandenberg, L. N., Lemire, J. M., and M. Levin, (2013),
Serotonin has early, cilia-independent roles in Xenopus
left-right patterning, Disease Models and Mechanisms,
6(1): 261-268 [cover]
PDF
 Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M., (2013),
Bioelectric signaling regulates head and organ size during planarian regeneration,
Development, 140(2): 313-322
PDF
2012
Vandenberg, L. N., Stevenson, C., and M. Levin, (2012),
Low frequency vibrations induce malformations in two aquatic
species in a frequency-, waveform-, and direction-specific
manner, PLoS One, 7(12): e51473
PDF
Pai, V. P., Vandenberg, L. N., Blackiston, D. J., and Levin, M.,
(2012), Neurally-derived tissues in Xenopus laevis
embryos exhibit a consistent bioelectrical left-right asymmetry,
Stem Cells International, 2012: 353491, doi:10.1155/2012/353491
PDF
Lobikin, M., Chernet, B., Lobo, D., and Levin, M., (2012),
Resting potential, oncogene-induced tumorigenesis, and
metastasis: the bioelectric basis of cancer in vivo,
Physical Biology, 9(6): 065002 [cover]
PDF
Lobikin, M., Wang, G., Xu, J.-S., Hsieh, Y.-W., Chuang, C.-F., Lemire, J. M.,
and M. Levin, (2012), Early, nonciliary role for microtubule proteins in left–right patterning
is conserved across kingdoms, Proceedings of the National Academy of Sciences of the United States,
109(31): 12586-12591
PDF
Tseng, A.-S., and Levin, M., (2012), Transducing bioelectrical signals into
epigenetic pathways during tadpole tail regeneration,
Anatomical Record, 295(10): 1541-1551
PDF
Levin, M., (2012), Morphogenetic fields in embryogenesis, regeneration, and cancer:
non-local control of complex patterning, BioSystems, 109(3): 243-261
PDF
Vandenberg, L.N., Adams, D. S., and Levin, M., (2012), Normalized shape
and location of perturbed craniofacial structures in the Xenopus tadpole
reveal an innate ability to achieve correct morphology,
Developmental Dynamics, 241(5): 863-878 [cover]
PDF
Blackiston, D. J., and Levin, M., (2012), Aversive training methods
in Xenopus laevis: general principles, Cold Spring Harbor Protocols, 2012(5): 521-527
PDF
Beane, W. S., Tseng, A.-S., Morokuma, J. M., Lemire, J. M., and
Levin, M., (2012), Inhibition of
planar cell polarity extends neural growth during regeneration, homeostasis,
and development, Stem Cells and Development, 21(12):
2085-2094 [cover]
PDF
Chernet, B. T., Adams, D. S., and Levin, M., (2012), Photoconversion for Tracking
the Dynamics of Cell Movement in Xenopus laevis Embryos,
Cold Spring Harbor Protocols, 2016(6): 683-690 [cover]
PDF
Chernet, B. T., and Levin, M., (2012), A versatile protocol for mRNA
electroporation of Xenopus laevis embryos, Cold Spring Harbor Protocols, 2012(4): 447-452
PDF
Adams, D. S., and Levin, M., (2012),
General principles for measuring resting
membrane potential and ion concentration using fluorescent bioelectricity
reporters, Cold Spring Harbor Protocols, 2012(4): 385-397 [cover]
PDF
Adams, D. S., and M. Levin, (2012), Measuring resting membrane potential
using the fluorescent voltage reporters DiBAC4(3) and CC2-DMPE,
CSHL Protocols, doi: 10.1101/pdb.prot067702
PDF
Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M., (2012), Transmembrane
voltage potential controls embryonic eye patterning in Xenopus laevis,
Development, 139(2): 313-323
PDF
Levin, M.,
(2012), Molecular bioelectricity in developmental biology: new
tools and recent discoveries, BioEssays, 34(3): 205-217
[cover]
PDF
Vandenberg, L. N., and Levin, M., (2012), Polarity proteins are
required for left-right axis orientation and twin-twin instruction,
Genesis, 50(3): 219-234
PDF
Levin, M., and Stevenson, C., (2012), Regulation of Cell
Behavior and Tissue Patterning by Bioelectrical Signals: challenges and
opportunities for biomedical engineering, Annual Reviews in
Biomedical Engineering, 14: 295-323
PDF
Lobo, D., Beane, W., and Levin, M., (2012), Modeling planarian
regeneration: a primer for reverse-engineering the worm,
PLoS Computational Biology, 8(4): e1002481 [cover]
PDF
2011
 Blackiston, D.,
Adams, D. S., Lemire, J. M., Lobikin, M., and
Levin, M., (2011), Transmembrane potential of GlyCl-expressing
instructor cells induces a neoplastic-like conversion of
melanocytes via a serotonergic pathway, Disease Models and Mechanisms, 4(1): 67-85 [cover]
PDF
Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M., (2011),
A chemical genetics approach reveals H,K-ATPase-mediated
membrane voltage is required for planarian head regeneration.
Chemistry & Biology, 18(1): 77-89
PDF
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and
Calegari, F., (2011), The H(+) vacuolar ATPase maintains neural stem cells in the developing
mouse cortex, Stem Cells
and Development, 20(5): 843-850
PDF
Carneiro, K., Donnet, C., Rejtar, T., Karger, B. L., Díaz, E., Kortagere, S.,
Lemire, J. M., and Levin, M. (2011), Histone
deacetylase activity is necessary for left-right patterning
during vertebrate development, BMC Developmental Biology, 11: 29
PubMed |
PDF
Vandenberg, L. N., Pennarola, B. W., and Levin, M., (2011),
Low frequency vibrations disrupt left-right patterning in the Xenopus embryo,
PLoS One, 6(8): e23306
PDF
Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and
Omenetto, F., (2011), Patterned femtosecond-laser
ablation of Xenopus laevis melanocytes for studies of cell
migration, wound repair, and developmental processes,
Biomedical Optics Express, 2(8): 2383-2391
PDF
Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D.,
Branch, M. R., and Adams, D. S., (2011), Long-distance
signals are required for morphogenesis of the regenerating
Xenopus tadpole tail, PLoS One, 6(9): e24953
PDF
Tseng, A-S., Carneiro, K., Lemire, J. M., and Levin, M., (2011),
HDAC activity is required during Xenopus tail
regeneration, PLoS One, 6(10): e26382
PDF
Levin, M. (2011), Endogenous bioelectrical signals in
development, regeneration, and neoplasm, in
Topical
Talks: The Biomedical & Life Sciences Collection, Henry Stewart
Talks Ltd, London.
Presentation
Levin, M. (2011), Left-Right Asymmetry in Embryonic
Development: How epigenetic, biophysical forces and gene
activity interplay to determine a major embryonic axis,
in Topical Talks: The Biomedical & Life Sciences Collection,
Henry Stewart Talks Ltd, London.
Presentation
Levin, M., (2011), Endogenous Bioelectric Signals as
Morphogenetic Controls of Development, Regeneration, and
Neoplasm, in The Physiology of Bioelectricity in
Development, Tissue Regeneration, and Cancer, C. Pullar (Ed.),
CRC Press: Boca Raton, FL, p. 39-89
Available here
Levin, M., (2011), The wisdom of the body: future
techniques and approaches to morphogenetic fields in
regenerative medicine, developmental biology, and cancer.
Regenerative Medicine, 6(6): 667-673
PDF
2010
Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M., (2010), A second-generation device for automated
training and quantitative behavior analyses of molecularly-tractable model organisms, PLoS One, 5(12): e14370
PDF
Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn,
J. M., Hwang, J. S., Gojobori, T., and Levin, M., (2010),
Long-range Neural and Gap Junction Protein-mediated Cues
Control Polarity During Planarian Regeneration,
Developmental Biology, 339: 188-199 [cover]
PDF
Vandenberg, L. N., and M. Levin, (2010), Consistent
left-right asymmetry cannot be Established by late organizers in
Xenopus unless the late organizer is a conjoined twin,
Development, 137, 1095-1105 [cover]
PDF
Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q.,
Carneiro, K., and Levin, M., (2010), The ATP-sensitive
K+-channel (KATP) controls early left-right patterning in
Xenopus and chick embryos. Developmental Biology, 346:
39-53
PDF
Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and M.
Levin, (2010),
 Induction of vertebrate regeneration by a
transient sodium current, Journal of Neuroscience,
30(39): 13192-13200 [cover]
PDF
Hechavarria, D., Dewilde, A., Braunhut, S., Levin, M., and
Kaplan, D. K., (2010), BioDome regenerative sleeve for
biochemical and biophysical stimulation of tissue regeneration.
Medical Engineering and Physics, 32: 1065-1073
PDF
 Blackiston, D., Vandenberg, L. N., and Levin, M., (2010),
High-throughput Xenopus laevis immunohistochemistry
using agarose sections. Cold Spring Harbor Protocols,
doi:10.1101/pdb.prot5532
PDF
Vandenberg, L. N., and Levin, M., (2010), Far from
solved: a perspective on what we know about early mechanisms of
left-right asymmetry. Developmental Dynamics, 239:
3131-3146 [cover]
PDF
2009
Aw, S., and Levin, M., (2009), Is left-right asymmetry a
form of planar cell polarity?, Development, 136:
355-366
Vandenberg, L., and Levin, M., (2009), Perspectives and
open problems in the early phases of left-right patterning,
Seminars in Cell and Developmental Biology, 20: 456-463 [cover]
PDF
Zhang, Y., and M. Levin, (2009), Particle tracking model
of electrophoretic morphogen movement reveals stochastic
dynamics of embryonic gradient, Developmental Dynamics,
238(8): 1923-1935
PDF
Zhang, Y., and M. Levin, (2009), Left-right asymmetry in
the chick embryo requires core planar cell polarity protein
Vangl2, Genesis, 47(11): 719-728
PDF
Levin, M. (2009), Bioelectric mechanisms in
regeneration: Unique aspects and future perspectives.
Seminars in Cell and Developmental Biology, 20: 543-556
PDF
Levin, M., (2009), Errors of Geometry: regeneration in a
broader perspective. Seminars in Cell and Developmental
Biology, 20(6): 643-645
PDF
Levin, M., (2009), Regeneration: recent advances, major
puzzles, and biomedical opportunities. Seminars in Cell
and Developmental Biology, 20(5): 515-516
PDF
Levin, M., Sundelacruz, S., Levin M., Kaplan, D. L., (2009),
Role of membrane potential in the regulation of cell
proliferation and differentiation, Stem Cell Reviews,
5(3): 231-46
PDF
 Blackiston, D. J., K. McLaughlin, and Levin, M., (2009),
Bioelectric controls of cell proliferation: ion channels,
membrane voltage, and the cell cycle, Cell Cycle,
8(21): 3527-3536 [cover]
PDF
2008
Morokuma, J., Blackiston, D., and Levin, M., (2008),
KCNQ1 and KCNE1 K+ channel components are involved in early
left-right patterning in Xenopus embryos, Cellular
Physiology and Biochemistry, 21: 357-372
PDF
Oviedo, N. J., B. J. Pearson, M. Levin, and A. S. Alvarado,
(2008), Planarian PTEN homologs regulate stem cells and
regeneration through TOR signaling, Disease Models and
Mechanisms, 1: 131-143
PDF
Morokuma, J., Blackiston, D., Adams, D. S., Seebohm, G.,
Trimmer, B., and Levin, M., (2008), Modulation of potassium
channel confers a hyper-proliferative invasive phenotype on embryonic
stem cells, Proceedings of the National Academy of Sciences of the United States, 105(43): 16608-16613
PDF
Sundelacruz, S., M. Levin, and D. L. Kaplan, (2008),
Membrane potential controls adipogenic and osteogenic
differentiation of mesenchymal stem cells, PLoS One,
3(11): e3737, 1-15
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M.,
(2008), Live imaging of planarian membrane potential
using DiBAC4(3). Cold Spring Harbor Protocols,
doi:10.1101/pdb.prot5055
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M.,
(2008), Gene knockdown in planarians using RNA
interference. Cold Spring Harbor Protocols,
doi:10.1101/pdb.prot5054
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M.,
(2008), Establishing and maintaining a colony of
planarians. Cold Spring Harbor Protocols,
doi:10.1101/pdb.prot5053
PDF
Oviedo, N., and Levin, M., (2008), Planarian
regeneration model as a context for the study of drug effects and
mechanisms, in Planaria: A Model for Drug Action
and Abuse, R. B. Raffa & S.M. Rawls (Eds.), RG Landes Co.: Austin, p. 95-104
Nicolas, C.L., Abramson, C.I., and Levin, M. (2008),
Analysis of behavior in the planarian model, in
Planaria: A Model for Drug Action and Abuse,
R. B. Raffa & S.M. Rawls (Eds.), RG Landes Co.: Austin, p. 83-94
Aw, S., and Levin, M., (2008), What's Left in Asymmetry?,
Developmental Dynamics, 237: 3453-3464
PDF
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008),
Planarians: a versatile and powerful model system for molecular
studies of regeneration, adult stem cell regulation, aging, and behavior,
in Emerging Model Organisms: A Laboratory Manual, Volume 1, Cold Spring Harbor Press: Cold Spring Harbor, NY
PDF
Tseng, A-S., and Levin, M., (2008), Tail regeneration in
Xenopus laevis as a model for understanding tissue repair,
Journal of Dental Research, 87(9): 806-816
PDF
2007
Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., and Levin, M. (2007),
Apoptosis is required during early stages of tail
regeneration in Xenopus laevis. Developmental Biology,
301: 62-69
PDF
Adams, D. S., Masi, A., and Levin, M. (2007), H+
Pump-dependent changes in membrane voltage are an early
mechanism necessary and sufficient to induce Xenopus tail regeneration.
Development, 134: 1323-1335 [cover]
PDF
Oviedo, N. J., Levin, M., (2007), smedxin-11 is a
Planarian Stem Cell Gap Junction Gene Required for Regeneration
and Homeostasis. Development, 134(17): 3121-3131
PDF
Aw, S., Adams, D. S., Qiu, D., and Levin, M., (2007),
H,K-ATPase protein Localization and Kir4.1 function reveal
concordance of three axes during early determination of left-right
asymmetry, Mechanisms of Development, 125: 353-372
PDF
Koustubhan, P., Sorocco, D., and Levin, M., (2007),
Establishing and maintaining a Xenopus laevis
colony for research laboratories,
in M. Conn (Ed.), Source Book of Models for Biomedical Research,
Humana Press, p. 139-160
Levin, M., Palmer, R., (2007), Left-right patterning
from the inside out: widespread evidence for intracellular control, BioEssays, 29: 271-287
PDF
 Levin, M., (2007), Gap junctional communication in
morphogenesis. Progress in Biophysics and Molecular
Biology, 94 (1-2): 186-206
PDF
Levin, M., (2007), Large-Scale Biophysics: Ion Flows and
Regeneration. Trends in Cell Biology, 17(6): 261-270
[cover]
PDF
Ingber, D., and Levin, M. (2007), What lies at the
interface
 of regenerative medicine and developmental biology?.
Development, 134: 2541-2547 [cover]
PDF
Oviedo, N., and Levin, M. (2007), Gap junctions provide
new links in Left-Right patterning, Cell, 129: 645-647
PDF
2006
Hibino, T., Ishii, Y., Levin, M., and Nishino, A., (2006),
Ion flow regulates left-right asymmetry in sea urchin
development. Development, Genes and Evolution, 216(5):
265-76
PDF
Shimeld, S. M., and Levin, M., (2006), Evidence for the
regulation of left-right asymmetry in Ciona intestinalis by ion
flux. Developmental Dynamics, 235(6): 1543-1553
PDF
Adams, D. S., Robinson, K. R., Fukumoto, T., Yuan, S., Albertson, R. C.,
Yelick, P., Kuo, L., McSweeney, M., and Levin M., (2006), Early,
H+-V-ATPase-dependent proton flux is necessary for consistent left-right
patterning of non-mammalian vertebrates. Development, 133: 1657-1671
PDF
Hicks, C., Sorocco, D., and Levin, M., (2006), Automated
Analysis of Behavior: A Computer-Controlled System for Drug
Screening and the Investigation of Learning. Journal of
Neurobiology, 66(9): 977-90
PDF
Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M.,
(2006), Mathematical Model of Morphogen
Electrophoresis through Gap Junctions. Developmental
Dynamics, 235(8): 2144-2159
PDF
Adams, D. S., and Levin, M., (2006), Inverse Drug
Screens: a rapid and inexpensive method for implicating
molecular targets. Genesis, 44: 530-540
PDF
Adams, D., and Levin, M., (2006), Strategies and
techniques for investigation of biophysical signals in
patterning, in Analysis of Growth Factor signaling in
Embryos, M. Whitman and A. K. Sater eds., pp. 177-264,
Methods in Signal Transduction Series, CRC Press
Levin, M., Lauder, J., and Buznikov, G., (2006), Of Minds and Embryos: Left-Right Asymmetry and the
Serotonergic Controls of Pre-Neural Morphogenesis. Developmental Neuroscience,
28:171-185 [cover]
PDF
Levin, M., (2006), Is the Early Left-Right Axis like a
Plant, a Kidney, or a Neuron? The Integration of Physiological
Signals in Left-Right Asymmetry. Birth Defects Research
(Part C), 78: 191-223
PDF
2005
Fukumoto, T., and Levin, M., (2005), Asymmetric
expression of Syndecan-2 in early chick embryogenesis.
MOD: Gene Expression Patterns, 5(4): 525-528
PDF
Fukumoto, T., Kema, I., and Levin, M., (2005), Serotonin
signaling is a very early step in patterning of the left-right
axis in chick and frog embryos. Current Biology, 15(9):
794-803
PDF
Nogi, T., Yuan, Y., Sorocco, D., Perez-Tomas, R., and M. Levin,
(2005), Eye regeneration assay reveals an invariant
functional left-right asymmetry in the early bilaterian, Dugesia
japonica. Laterality, 10(3): 193-205
PDF
Qiu, D., Cheng, S.M., Wozniak, L., McSweeney, M., Perrone, E.,
and Levin, M., (2005), Localization and loss-of-function
implicates ciliary proteins in early, cytoplasmic roles in
left-right asymmetry. Developmental Dynamics, 234:
176-189
PDF
Shin, J-B., Adams, D., Paukert, M., Siba, M., Sidi, S., Levin,
M., Gillespie, P. G., and Grunder, S., (2005), Xenopus
TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial
cells, including inner-ear hair cells. P.N.A.S.,
102(35): 12572-12577
PDF
Gamer L. W., Nove J., Levin M., Rosen V., (2005), BMP-3
is a novel inhibitor of both activin and BMP-4 signaling in
Xenopus embryos. Developmental Biology, 285(1): 156-68
PDF
Nogi, T., and Levin, M., (2005), Characterization of
innexin gene expression and functional roles of gap-junctional
communication in planarian regeneration.
Developmental Biology, 287: 314-335
PDF
 Fukumoto, T., Blakely, R., and Levin, M., (2005),
Serotonin transporter function is an early step in left-right
patterning in chick and frog embryos. Developmental
Neuroscience, 27(6): 349-363
PDF
Levin, M., (2005), Left-right asymmetry in embryonic
development: a comprehensive review. Mechanisms of
Development, 122(1): 3-25 [cover]
PDF
2004
Levin, M., (2004), A novel immunohistochemical method
for evaluation of antibody specificity and detection of labile
targets in biological tissue. Journal of Biophysical
and Biochemical Methods, 58: 85-96
PDF
Levin, M., (2004), The embryonic origins of left-right
asymmetry. Critical Reviews in Oral Biology and
Medicine, 15(4): 197-206
PDF
Adams, D. S., and Levin, M. (2004). Early Patterning of
the Left/Right Axis. In Gastrulation: from cells to
embryo (C. D. Stern, Ed.), pp. 403-417. Cold Spring Harbor, New
York. PDF
2003
Bunney, T. D., De Boer, A. H., and M. Levin, (2003),
Fusicoccin signaling reveals 14-3-3 protein function as a novel
step in left-right patterning during amphibian embryogenesis,
Development, 130: 4847-4858
PDF
Levin, Michael, (2003), Left-Right Asymmetry in
Amphibian Embryogenesis, in Developmental Biology, Vol.
6 of Biology of the Amphibia, edited by Harold Heatwole and
Brenda Brizuela
Levin, M., (2003), Bioelectromagnetics in
morphogenesis. Bioelectromagnetics, 24(5): 295-315
PDF
Levin, M., (2003), Motor protein control of ion flux is
an early step in embryonic Left-Right asymmetry.
BioEssays, 25(10): 1002-1010
PDF
2002
Levin, Michael, T. Thorlin, K. Robinson, T. Nogi, and M.
Mercola, (2002), Asymmetries in H+/K+-ATPase and cell membrane
potentials comprise a very early step in left-right patterning.
Cell, 111: 77-89
PDF
Rutenberg, J., Cheng, S. M., and Levin, M., (2002), Early
embryonic expression of ion channels and pumps in chick and
Xenopus development. Developmental Dynamics, 225(4):
469-484
PDF
Cheng, S. M., Chen, I., and Levin, M., (2002), Katp channel
activity is required for hatching in Xenopus.
Developmental Dynamics, 225(4): 588-591
PDF
Levin, Michael, (2002), Isolation and community: A review of
the role of gap-junctional communication in embryonic patterning.
Journal of Membrane Biology, 185(3): 177-192
PDF
2001
Mercola, M., and Levin, M., (2001), Left-Right asymmetry
determination in vertebrates. Annual Review of Cell and
Developmental Biology, 17: 779-805
PDF
Levin, Michael, (2001), Asymmetry of Body and Brain:
Embryological and Twin Studies. In: Smelser N, Baltes P
(eds.) International Encyclopedia of the Social and Behavioral
Sciences. Elsevier, Oxford, UK, pp. 853-9
PDF
2000
Levin, Michael, and Mercola, M., (2000), Expression of
Connexin30 in Xenopus embryos and its involvement in hatching
gland function, Developmental Dynamics, 219(1): 96-101
PDF
1999
Levin, Michael, (1999), Matrix-based GA representations in a model of evolving animal communication,
in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms: Complex Coding Systems, Vol. 3, ch.5, pp. 103-117, CRC Press: Boca Raton, FL
Levin, Michael, (1999), Twinning and embryonic
left-right asymmetry. Laterality: Asymmetries
of Body, Brain and Cognition, 4(3): 197-208
PDF
Zhu, L., Marvin,M. J., Gardiner, A., Lassar, A. B., Mercola,
M., Stern, C. D., and Levin, M., (1999), Cerberus
regulates left-right asymmetry of the embryonic head and heart.
Current Biology, 9(17): 931-938
PDF
Levin, Michael, and Mercola, M., (1999), Gap
Junction-Mediated Transfer of Left-Right Patterning Signals in
the Early Chick Blastoderm is Upstream of Shh Asymmetry in the
Node. Development, 126: 4703-4714
PDF
Levin, Michael, (1999), Left-right asymmetry in animal
embryogenesis, in Advances in Biochirality, edited by
G. Palyi, C. Zucchi, and L. Caglioti, ch. 12, p. 137-152,
Oxford, UK
PDF
Levin, Michael, (1999), Endogenous electromagnetic
fields and radiations in regeneration, development, and neoplasm,
Proceedings of the First World Congress on the Effects of
Electricity and Magnetism in the Natural World, Madeira,
Portugal
1998
Levin, Michael, (1998), The roles of activin and follistatin
signaling in chick gastrulation. International Journal of
Developmental Biology, 42(4): 553-559
PDF |
Figures
Levin, Michael, and Mercola, M., (1998), Gap junctions
are involved in the early generation of left right asymmetry.
Developmental Biology, 203(1): 90-105
PDF
Levin, Michael, and Mercola, M., (1998), Evolutionary
conservation of mechanisms upstream of asymmetric nodal expression:
Reconciling chick and Xenopus. Developmental
Genetics, 23(3): 185-193
PDF
Levin, Michael, (1998), Left-Right asymmetry and the
chick embryo. Seminars in Developmental Biology,
9: 67-76
PDF
Levin, Michael, and Mercola, M., (1998), The compulsion
of chirality: toward an understanding of left-right asymmetry.
Genes & Development, 12: 763-769
PDF
1997
Levin, Michael, and Ernst, Susan G., (1997), Applied
DC magnetic fields cause alterations in the time of cell divisions
and developmental abnormalities in early sea urchin embryos.
Bioelectromagnetics, 18(3): 255-263
PDF
Levin, Michael, Pagan, S., Roberts, D., Cooke, J., Kuehn, M.,
and Tabin, C., (1997), Left/Right patterning signals and the
independent regulation of different aspects of situs in the
chick embryo. Developmental Biology, 189: 57-67
PDF
Levin, Michael, and Nascone, N., (1997), Two molecular models
of initial left-right asymmetry generation. Medical
Hypotheses, 49(5): 429-435
PDF
Levin, Michael, (1997), Left-Right Asymmetry in
Vertebrate Embryogenesis. BioEssays, 19(4): 287-296 [cover]
PDF
1996
Levin, Michael, Roberts, D., Holmes, L., and Tabin, C., (1996),
Laterality defects in Conjoined Twins. Nature,
384: 321
PDF
1995
Levin, Michael, and Ernst, Susan G., (1995), Applied AC
and DC Magnetic-Fields Cause Alterations in the Mitotic-Cycle of
Early Sea-Urchin Embryos. Bioelectromagnetics,
16(4): 231-240
PDF
Levin, Michael, R. L. Johnson, C. D. Stern, M. Kuehn, and C.
Tabin, (1995), A molecular pathway determining
left-right asymmetry in chick embryogenesis. Cell, 82:
1-20 [ cover]
PDF
Levin, Michael, (1995), Use of Genetic Algorithms to
solve biomedical Problems. M.D. Computing, 12(3):
193-198
PDF
Levin, Michael, (1995), The evolution of understanding: A
genetic algorithm model of the evolution of animal communication.
BioSystems, 36: 167-178
PDF
Levin, Michael, (1995), Locating putative protein signal
sequences, in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms:
New Frontiers, Vol. 2, ch. 2, pp. 53-66, CRC Press: Boca
Raton, FL
PDF
1994
Levin, Michael, A Julia set model of field-directed
morphogenesis, (1994), Computer Applications in the
Biosciences, 10(2): 85-103
PDF |
Figures
Levin, Michael, (1994), Discontinuous and alternate
q-system fractals. Computers and Graphics, 18(6):
873-884
PDF
1993
Levin, Michael, Current and potential applications of
bioelectromagnetics in medicine, (1993), ISSEEM
Journal, 4(1): 77-87
PDF
Abstracts
- Blackiston, Douglas; Adams, Dany; Lemire, Joan; Levin, Michael, (2010), "Transmembrane
voltage gradient in GlyR-expressing niche cells controls behavior of neural
crest derivatives in vivo", Developmental Biology, 344(1): 526
- Oviedo, N. J.; Morokuma, J.; Walentek, P.; Kema, I. P.; Gu, M. B.; Ahn, J.M.; Hwang, J. S.;
Gojobori, T.; Levin, M., (2010), "Long-range
neural and gap junction protein-mediated cues control polarity during
planarian regeneration", Developmental Biology, 344(1): 522
- Tseng, A. S., Beane, W. S., Lemire, J. M., Masi, A., Levin, M. (2010), "NaV-mediated
sodium transport is required for vertebrate appendage regeneration",
Developmental Biology, 344(1): 519
- Beane W. S., Morokuma J., Levin M., (2010), "H,K-ATPase-mediated
ion transport regulates anterior patterning in regenerating planaria",
Developmental Biology, 344(1): 522
- Vandenberg, L., and Levin, M., (1010), "The Par6 complex is
required for both early and late orientation of the left-right axis in
Xenopus", Developmental Biology, 344(1): 426-427
- Beane W. S., Oviedo N.J., Adams D. S., Levin M. (2009), "H,K-ATPase-mediated
ion transport regulates anterior patterning in regenerating planaria",
Mechanisms of Development, 126 (Sup. 1): S294-S295
- Morokuma, J., and Levin, M., (2006), "Role of KvLQT-1/minK K+
channel in early embryonic patterning", Developmental Biology,
295(1): 451-
- Blum, M., Schweickert, A., Beyer, T., Weber, T., Andre, P., Fischer,
A., Viebahn, C., M. Levin, (2006), "A leftward fluid flow precedes nodal
induction in Xenopus", Developmental Biology, 295(1): 443
- Adams, D. S., Masi, A., Levin, M., (2006), "Xenopus tadpole tail
regeneration requires the activity of the proton pump V- ATPase, and proton
pumping is sufficient to partially rescue the loss of function phenotype"
Developmental Biology, 295(1): 355-356
- Levin, M., Adams, D. S., Aw, S., Morokuma, J., Oviedo, N. J., (2006), "Bioelectrical
controls of morphogenesis" Developmental Biology, 295(1):331-332
- Chen, I., and Levin, M., (2004). "The Role of KATP Channels in
Development of Left-Right Asymmetry in Xenopus",
Journal of Dental
Research., 83: A1340.
- Nogi, T. and Levin, M., (2003),"Electrical Controls
of Regeneration in Planaria", Developmental Biology, 259: 586
- Levin, M., (2003), "Electric Embryos: Endogenous Ion Fluxes and
Voltage Gradients in Left—Right Asymmetry", Developmental Biology,
259: 482
- Adams, D., and Levin, M., (2003), "Elements of Left—Right
Patterning: Gap Junctions, pH, and Membrane Voltage",
Developmental
Biology, 259: 482
- Fukumoto, T., and Levin, M., (2003), "Serotonin Is a Novel Very
Early Signaling Mechanism in Left—Right Asymmetry",
Developmental
Biology, 259: 490
- Levin, M., and Mercola, M. (1999), "Gap junction-mediated
transfer of left-right patterning signals", Molecular Biology of
the Cell, 39: 1
- Pagan S. M., Levin M., Tabin C., (1997),"From left-right
asymmetric gene expression to its morphological manifestations",
Journal of Morphology, 232(3): 306
- Levin, M., Gonzalez, J. L., and Ernst, Susan G., (1991), "DC and
AC magnetic field effects on early sea-urchin development",
Biological Bulletin, 181: 511-
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