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Faculty & Research



Contact Info:
Department of Biology
Tufts University
Robinson Hall, Room 368
200 College Ave
Medford, MA 02155

Tel: 617-627-3196
Fax: 617-627-3805
Email Dr. Crowe

Lauren Crowe
Lecturer
Cell Biology

Education

TEACRS Postdoctoral fellow, Tufts University, 2016-2019
Ph.D., Cell Biology, Duke University, 2010-2016
B.S., University of North Carolina at Chapel Hill, 2006-2010

*Teaching faculty member – not accepting research students

Research Interests
I am interested in cellular and molecular biology — how our gene expression affects cell and organismal physiology and development.
In graduate school, I investigated how proteins that regulate actin branching and growth affect neurodevelopment in mice through in vivo imaging and behavioral studies and neuron cultures. I found that defects in actin branching negatively affect neuronal outgrowth and synapse formation in the cerebellum Purkinje cells, leading to motor learning abnormalities. I also investigated the use of fluorescent reporter compounds in the identification and characterization of malignant breast cancer cells and their metabolism. Hsp90, a canonically intracellular molecular chaperone, gets secreted and re-endocytosed in malignant breast cancer cells, making it an ideal target for binding with non-cell permeable compounds that can then accumulate in malignant cells without affecting physiologically normal cells.

During my postdoctoral training, I studied how astrocytes and neurons communicate to promote sleep and circadian rhythms in Drosophila melanogaster. I used the vast genetic resources available to Drosophila researchers to investigate signaling pathways important for night sleep and rebound after sleep deprivation. In addition, as a TEACRS (Training in Education and Critical Research Skills) scholar, I took a particular interest in mentoring undergraduate students and student volunteers in the lab with an emphasis on developing the critical thinking and organization skills necessary to be a successful scientist.

Courses

Bio 13: Cells and Organisms
Bio 46: Cell Biology
Bio 94/194: Introduction to Research/Independent Research


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