Research and Publications: Recent Publications

Peer-Reviewed Papers

Abraham, L.C., Dice, J.F., Finn, P.F., Mesires, N.T., Lee, K. and Kaplan, D.L.  Extracellular matrix remodeling – methods to quantify cell-matrix interactions. Biomaterials, 28: 151-161 (2007).

Abraham, L.C., Dice, J.F., Lee, K. and Kaplan, D.L. Phagocytosis and remodeling of collagen matrices.  Experimental Cell Research 313:1045-1055, (2007).

Bettinger, C., Kim, H-J., Borenstein, J., Langer, R., Kaplan, D. L.  Silk fibroin microfluidic devices.  Adv. Materials, in press (2007).

Bini, E., Wong, C., Huang, J., Karageorgiou, V., Kitchel, B. and Kaplan, D.L.  RGD-Functionalized Bioengineered Spider Dragline Silk Biomaterial. Biomacromolecules, 7:3139-3145, (2007).

*Cannizzaro, C., Tandon, N., Figallo, E., Park, H., Gerecht, S., Radisic, M., Elvassore, N., Vunjak-Novakovic, G. Practical aspects of cardiac tissue engineering with electrical stimulation. Methods in Molecular Medicine, Tissue Engineering (H Hauser and M. Fussenegger), Humana Press, 291-307, (2007).

Chao, G., Grayson, W. and Vunjak-Novakovic, G. Engineering cartilage and bone using human mesenchymal stem cells.  Journal of Orthopaedic Science, 12(4), (2007). 

#Chang G, Jin HJ, Kaplan DL, Vunjak-Novakovic G and Kandel R. Porous silk scaffolds can be used for tissue engineering annulus fibrosus. European Spine Journal Epub ahead of print, April 20, 2007

Egles, C., Mauney, J., Volloch, V., Kaplan, D. L., Garlick, G. Denatured collagen modulates the phenotype of normal and wounded human skin equivalents.  J. Investigative Dermatology, in press (2007).

Ferreira L, Gercht-Nir S, Shieh H, Vunjak-Novakovic G and Langer R. Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials 28(17): 2706-2717 (2007) Highlighted in Materials Today: Hydrogels make stem cells differentiate 10(5): 10 (May 2007)

Ferreira L, Gerecht-Nir S, Shieh H, Vunjak-Novakovic G and Langer R. Vascular progenitor cells isolated from human embryonic stem cells Circulation Research 101(3):286-294 (2007)

*Figallo, E., Cannizzaro, C., Gerecht-Nir, S., Burdick, J., Langer, R., Elvassore, N. and Vunjak-Novakovic, G.  Microbioreactor for controlled differentiation of human embryonic stem cells. Lab on a Chip, 7(6):710-719 (2007) Cover article

Georgakoudi, I., I. Tsai, C. Greiner, C. Wong, J. DeFelice, D. Kaplan.  Intrinsic fluorescence changes associated with the conformational state of silk fibroin in biomaterial matrices.  Optics Express 15:1043-1053(2007).

*Gerecht-Nir, S., Burdick, J.A., Ferreira, L.S., Townsend, S.A., Langer, R. and Vunjak-Novakovic, G. Propagation of undifferentiated human embryonic stem cells in hyaluronic acid hydrogels. PNAS, 104(27):11298-11303 (2007)

*Gerecht-Nir S, Bettinger CJ, Zhang Z, Borenstein J, Vunjak-Novakovic G, Langer R. The effect of actin disrupting agents on contact guidance of human embryonic stem cells.. Biomaterials 28(28):4068-4077 2007

#,*Hagenmller H, Hofmann S, Kohler T, Merkle HP, Kaplan DL, Vunjak-Novakovic G, Mller R and Meinel L. Noninvasive time-lapsed monitoring and quantification of engineered bone-like tissue. Annals of Biomedical Engineering 2007 Jun 2; [Epub ahead of print]

#,*Hoffman S, Hagenmueller H, Koch A, Mueller R, Vunjak-Novakovic G, Kaplan D, Merkle HP and Meinel LW. Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds. Biomaterials 28(6):1152-1562, 2007

#,*Hofmann, S., Hagenmueller, H., Uebersax, L., Gruenblatt, E., Merkle, H.P., Mueller, R., Vunjak-Novakovic, G., Kaplan, D. and Meinel, L. Effect of scaffold design on bone morphology in vitro. Tissue Engineering, (in press)

*Huang, J., Wong, C., George, A., Kaplan, D. L. The Effect of Genetically Engineered Spider Silk-Dentin Matrix Protein 1 Chimeric Protein on Hydroxyapatite Nucleation. Biomaterials. 28:2358-2367 (2007)

Hu, X., Kaplan, D. L., Cebe, P. Effect of water on the thermal properties of silk fibroin.  Cebe.  Thermochimica Acta. In press (2007).

*Iyer R, Radisic M, Cannizzaro C and Vunjak-Novakovic G. Oxygen carriers in cardiac tissue engineering. Artificial Cells Blood Substitutes and Biotechnology 35 (1): 135-148 (2007)

*Jiang, C., X. Wang, R. Gunawidjaja, Y-H. Lin, M. K. Gupta, D. L. Kaplan, R. R. Naik, V. V. Tsukruk. Mechanical properties of robust ultrathin silk fibroin films. Advanced Functional Materials 17:2229-2237.

*Khademhosseini A, Eng G, Yeh J, Kucharczyk S, Langer R, Vunjak-Novakovic G and Radisic M. Microfluidic patterning for fabrication of contractile cardiac organoids. Biomedical Microdevices 9(2): 149-157 (2007)

Kim, H-J., U-J Kim, G. G. Leisk, C. Bayan, I. Georgakoudi, D. L. Kaplan. Bone regeneration on macroporous aqueous-derived silk 3D Scaffolds.  Macromol. Bioscience, 7643-655 (2007).

*Limem, S, Calvert, P., Kim, H. J., Kaplan, D. L. Differentiation of bone marrow stem cells on ink jet printed silk lines.  In press (2007).

#,*Lovett M, Cannizzaro C, Daheron L, Murphy A, Vunjak-Novakovic G and Kaplan DL. Silk fibroin microtubes for potential application in blood vessel engineering. Biomaterials, in press (2007).

*Lu, D., Mahmood A, Qu C., Goussv A., Xiong Ye, Jiang F, Hong X, Zhang XP, Mauney J., Volloch V., Kaplan DL, Chopp M. Collagen scaffolds populated with human marrow stromal cells reduce lesion volume and improve functional outcome after traumatic brain injury. Neurosurgery, in press (2007).

*Mauney, J. R., T. Nguyen, K. Gillen, C. Kirker-Head, J. M. Gimble, D. L. Kaplan. Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds.  Biomaterials. In press (2007).

Moreau, J., Anderson, K., Mauney, J., Kaplan, D. L., Rosenblatt, M. Tissue engineered bone serves as a target for metastasis of human breast cancer in a mouse model.  Cancer Research, In press (2007).

*Obradovic B, Radisic M, and Vunjak-Novakovic G. Oxygen transport in tissue engineering systems: cartilage and myocardium. Fluid Dynamics and Materials Processing, in press, (2007).

*Park, H., Cannizzaro, C., Langer, R., Vunjak-Novakovic, G., Vacanti, C.A. and Farokhzad, O.C. Micro- and Nanofabrication of functional materials for tissue engineering (Review article) Tissue Engineering 13(8):1867-1877. 2007

*Radisic, M., Park, H., Gerecht-Nir, S., Cannizzaro, C., Langer, R. and Vunjak-Novakovic, G. Biomimetic approach to cardiac tissue engineering. Philosophical Transactions of the Royal Society of London, 362(1484):1357-1368 (2007).

Radisic M., Park H., Salazar-Lazaro JE., Wang Y. Langer R., Freed LE., Vunjak-Novakovic G. Sequential cultivation of cardiac cell subpopulations results in robust contractile response of engineered cardiac tissue Journal of Biomedical Materials Research A, in press (2007).

Soffer, L., Wang, X., Zhang, X., Kluge, J., Dorfmann, L., Kaplan, D. L., Leisk, G. Silk-based electrospun tubular scaffolds for tissue engineered vascular grafts. J. Biomaterials Sci. Polymer Edn. In press (2007).

*Tilburey, G., Patwardhan, S. V., Huang, J., Kaplan, D. L., Perry, C. C. Are hydroxyl containing biomolecules important in (bio)silicification? A model study.  Angewandte Chemie, in press (2007).

Vepari, C., Kaplan, D. L.  Silk as a biomaterial. Progress in Polymer Science, in press (2007).

*Wang, X., Wnek, E., Matsumoto, A., Meinel, L., Li, C. and Kaplan, D.L. Silk microspheres for encapsulation and controlled release. J. Controlled Release. 117:360-370, (2007).

Books (2007)

Freshney I, Obradovic B Grayson W, Cannizzaro C and Vunjak-Novakovic G. Principles of tissue culture and bioreactor design. Principles of Tissue Engineering 3^rd ed.  (Lanza, Langer and Vacanti ed.) (in press)

*Gerecht-Nir, S., Cannizzaro, C., Figallo, E., Elvassore, N., and Vunjak-Novakovic, G. Bioreactors for the 3D cultivation of human embryonic stem cells. Human Embryonic Stem Cells (ed. J. Masters, B. Palsson, J. Thomson), Human Cell Culture Series, Springer Verlag, Ch. 9, pp. 149-172, (2007)

*Grayson W, Chao PhG, Marolt D, Radisic M, Cannizzaro C, Figallo E. and Vunjak-Novakovic G. Bioreactors for tissue engineering and regenerative medicine. Translational Approaches in Tissue Engineering and Regenerative Medicine Editors: Mao JJ, Vunjak-Novakovic G, Mikos A and Atala A. Artech House (in press)

Khademhosseini, A., Karp, J.M., Gerecht, S., Ferreira, L., Vunjak-Novakovic, G. and Langer, R. Embryonic stem cells as a Cell Source for Tissue Engineering. Principles of Tissue Engineering 3^rd ed.  (Lanza, Langer and Vacanti ed.) (in press).

Mao JJ, Vunjak-Novakovic G, Mikos A and Atala A (Editors) Translational Approaches in Tissue Engineering Artech House (in press)

*Obradovic B, Radisic M and Vunjak-Novakovic G. Tissue engineering of cartilage and myocardium. In: Applications of Cell Immobilization Biotechnology (V. Nedovic and R. Willaert ed.) Springer Verlag (in press)

Radisic M, Park H and Vunjak-Novakovic G. Cardiac tissue engineering. Principles of Tissue Engineering 3^rd ed.  (Lanza, Langer and Vacanti ed.) (in press)

Notations: Collaborative Publications are marked by *
Joint publications between the two cores are marked by #