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Contact Info:
Tufts University
Department of Psychology
530 Boston Avenue
Medford, MA 02155

Office: 617.627.3414
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Klaus Miczek
Professor of Psychology
Director, Behavioral Core of the Neuroscience Research Center, Sackler School of Biomedical Sciences

Education

Ph.D., University of Chicago, 1972

Biography

Klaus A. Miczek is the Moses Hunt Professor of Psychology, Psychiatry, Pharmacology and Neuroscience at Tufts University. He has served on research review committees for the National Institute on Drug Abuse, National Institute on Mental Health, National Institute on Alcoholism and Alcohol Abuse, and National Center for Research Resources. He was a member of the National Academy of Science panel on "Understanding and Preventing Violence" (1989-1992) as well as its ILAR/NRC panel on the "Psychological Well-being of Primates." He is the Coordinating and Principal Editor of Psychopharmacology since 1992, and he serves on the editorial board of half a dozen other journals in this area. He was the president of the Division of Psychopharmacology, and of the Behavioral Pharmacology Society, and chaired the Committee on Animals in Research and Ethics of the American Psychology Association. He has received numerous prizes including the Solvay Duphar Award of the Division of Psychopharmacology and Substance Abuse of the American Psychological Association, a MERIT award from NIAAA, Silver Medals of the Charles University (Czech Republic). In 1997, the president of the Federal Republic of Germany bestowed the Knight's Cross of the Order of Merit on him. Dr. Miczek was named the Boerhaave professor at the medical faculty of Leiden University (Netherlands) and was twice Japan International Science & Technology Fellow at the University of Tokyo. He was visiting professor at La Sapienza University in Rome, the Charles University in Prague and at the University of Tuebingen (Germany). In 2006, Tufts University recognized Dr. Miczek with the Distinguished Scholar Award, and he was elected fellow in the American Association for the Advancement of Science. He published some 200 research journal articles, 40 reviews and edited 20 volumes on psychopharmacological research concerning brain mechanisms of aggression, anxiety, social stress and abuse of alcohol and other drugs. He was originally educated in Berlin (Germany) and received his Ph.D. in Biopsychology from the University of Chicago.

Currently, the work in Dr. Miczek's laboratory investigates two problems in the areas of (1) stress and drug abuse, and (2) behavioral neurobiology of aggression. First, members of the laboratory aim to learn about neuroadaptive mechanisms via which specific social stressors can intensify compulsive drug use or alternatively engender depressive-like anhedonia. Second, they are seeking to characterize the neurobiological features of those individuals who engage in escalated aggression after alcohol consumption.

Representative Publications

Selected publications in last ten years (from more than 260)

  • Holly EN, Miczek KA (2016) Ventral tegmental area dopamine revisited: effects of acute and repeated stress. Psychopharmacology 233:163-186. doi: 10.1007/s00213-015-4151-3.
  • Hwa LS, Holly EN, DeBold JF, Miczek KA (2016) Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. Psychopharmacology 233:681-690. doi: 10.1007/s00213-015-4144-2.
  • Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA (2016) Dissociation of μ-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addiction Biology 21:111-124. doi: 10.1111/adb.12189.
  • Holly EN, Miczek KA (2015) Capturing individual differences: Challenges in animal models of posttraumatic stress disorder and drug abuse. Biological Psychiatry 78:816-818. doi: 10.1016/j.biopsych.2015.09.015.
  • Holly EN, DeBold JF, Miczek KA (2015) Increased mesocorticolimbic dopamine during acute and repeated social defeat stress: modulation by corticotropin releasing factor receptors in the ventral tegmental area. Psychopharmacology 232:4469-4479. doi: 10.1007/s00213-015-4082-z.
  • Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA (2015) α2-containing GABAA receptors: A requirement for midazolam-escalated aggression and social approach in mice. Psychopharmacology 232:4359-4369. doi: 10.1007/s00213-015-4069-9.
  • Miczek KA, DeBold JF, Hwa LS, Newman EL, de Almeida RM (2015) Alcohol and violence: Neuropeptidergic modulation of monoamine systems. Annals of the New York Academy of Sciences 1349:96-118. doi: 10.1111/nyas.12862.
  • Albrechet-Souza L, Hwa LS, Han X, Zhang EY, DeBold JF, Miczek KA (2015) Corticotropin releasing factor binding protein and CRF2 receptors in the ventral tegmental area: Modulation of ethanol binge drinking in C57BL/6J mice. Alcoholism, Clinical and Experimental Research 39:1609-1618. doi: 10.1111/acer.12825.
  • Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW (2015) The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. American Journal of Medical Genetics, Part A 167A:1993-2008. doi: 10.1002/ajmg.a.37156.
  • Burke AR, Miczek KA (2015) Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: Role of social experience and adaptive coping behavior. Psychopharmacology 232:3067-3079. doi: 10.1007/s00213-015-3947-5.
  • Miczek KA, Takahashi A, Gobrogge KL, Hwa LS, de Almeida RM (2015) Escalated aggression in animal models: Shedding new light on mesocorticolimbic circuits. Current Opinion in Behavioral Sciences 3:90-95. doi:10.1016/j.cobeha.2015.02.007.
  • Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. (2015) Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. The Journal of Neuroscience 35:6452-6463. doi: 10.1523/JNEUROSCI.2450-14.2015.
  • Hwa LS, Nathanson AJ, Shimamoto A, Tayeh JK, Wilens AR, Holly EN, Newman EL, DeBold JF, Miczek KA (2015) Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice. Psychopharmacology 232:2889-2902. doi: 10.1007/s00213-015-3925-y.
  • Yap JJ, Chartoff EH, Holly EN, Potter DN, Carlezon WA Jr, Miczek KA (2015) Social defeat stress-induced sensitization and escalated cocaine self-administration: The role of ERK signaling in the rat ventral tegmental area. Psychopharmacology 232:1555-1569. doi: 10.1007/s00213-014-3796-7.
  • Norman KJ, Seiden JA, Klickstein JA, Han X, Hwa LS, DeBold JF, Miczek KA (2015) Social stress and escalated drug self-administration in mice I. Alcohol and corticosterone. Psychopharmacology 232:991-1001. doi: 10.1007/s00213-014-3733-9.
  • Han X, Albrechet-Souza L, Doyle MR, Shimamoto A, DeBold JF, Miczek KA (2015) Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens. Psychopharmacology 232:1003-1010. doi: 10.1007/s00213-014-3734-8.
  • Shimamoto A, Holly EN, Boyson CO, DeBold JF, Miczek KA (2015) Individual differences in anhedonic and accumbal dopamine responses to chronic social stress and their link to cocaine self-administration in female rats. Psychopharmacology 232:825-34. doi: 10.1007/s00213-014-3725-9.

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