Department of Psychology
530 Boston Avenue
Medford, MA 02155
> Tufts Sackler Webpage
Professor of Psychology
Director, Behavioral Core of the Neuroscience Research Center, Sackler School of Biomedical Sciences
Ph.D., University of Chicago, 1972
Klaus A. Miczek is the Moses Hunt Professor of
Psychology, Psychiatry, Pharmacology and Neuroscience at Tufts
University. He has served on research review committees for the National
Institute on Drug Abuse, National Institute on Mental Health, National
Institute on Alcoholism and Alcohol Abuse, and National Center for
Research Resources. He was a member of the National Academy of Science
panel on "Understanding and Preventing Violence" (1989-1992) as well as
its ILAR/NRC panel on the "Psychological Well-being of Primates." He is
the Coordinating and Principal Editor of Psychopharmacology since
1992, and he serves on the editorial board of half a dozen other
journals in this area. He was the president of the Division of
Psychopharmacology, and of the Behavioral Pharmacology Society, and
chaired the Committee on Animals in Research and Ethics of the American
Psychology Association. He has received numerous prizes including the
Solvay Duphar Award of the Division of Psychopharmacology and Substance
Abuse of the American Psychological Association, a MERIT award from
NIAAA, Silver Medals of the Charles University (Czech Republic). In
1997, the president of the Federal Republic of Germany bestowed the
Knight's Cross of the Order of Merit on him. Dr. Miczek was named the
Boerhaave professor at the medical faculty of Leiden University
(Netherlands) and was twice Japan International Science & Technology
Fellow at the University of Tokyo. He was visiting professor at La
Sapienza University in Rome, the Charles University in Prague and at the
University of Tuebingen (Germany). In 2006, Tufts University recognized
Dr. Miczek with the Distinguished Scholar Award, and he was elected
fellow in the American Association for the Advancement of Science. He
published some 200 research journal articles, 40 reviews and edited 20
volumes on psychopharmacological research concerning brain mechanisms of
aggression, anxiety, social stress and abuse of alcohol and other drugs.
He was originally educated in Berlin (Germany) and received his Ph.D. in
Biopsychology from the University of Chicago.
Currently, the work in Dr. Miczek's laboratory
investigates two problems in the areas of (1) stress and drug abuse, and
(2) behavioral neurobiology of aggression. First, members of the
laboratory aim to learn about neuroadaptive mechanisms via which
specific social stressors can intensify compulsive drug use or
alternatively engender depressive-like anhedonia. Second, they are
seeking to characterize the neurobiological features of those
individuals who engage in escalated aggression after alcohol
Selected publications in last ten years (from more than 260)
- Holly EN, Miczek KA (2016) Ventral tegmental area dopamine
revisited: effects of acute and repeated stress.
Psychopharmacology 233:163-186. doi: 10.1007/s00213-015-4151-3.
- Hwa LS, Holly EN, DeBold JF, Miczek KA (2016) Social
stress-escalated intermittent alcohol drinking: modulation by
CRF-R1 in the ventral tegmental area and accumbal dopamine in
mice. Psychopharmacology 233:681-690. doi:
- Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold
JF, Miczek KA (2016) Dissociation of μ-opioid receptor and
CRF-R1 antagonist effects on escalated ethanol consumption and
mPFC serotonin in C57BL/6J mice. Addiction Biology 21:111-124. doi: 10.1111/adb.12189.
- Holly EN, Miczek KA (2015) Capturing individual differences:
Challenges in animal models of posttraumatic stress disorder and
drug abuse. Biological Psychiatry 78:816-818. doi:
- Holly EN, DeBold JF, Miczek KA (2015) Increased
mesocorticolimbic dopamine during acute and repeated social
defeat stress: modulation by corticotropin releasing factor
receptors in the ventral tegmental area. Psychopharmacology
232:4469-4479. doi: 10.1007/s00213-015-4082-z.
- Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold
JF, Rudolph U, Miczek KA (2015) α2-containing GABAA receptors: A
requirement for midazolam-escalated aggression and social
approach in mice. Psychopharmacology 232:4359-4369. doi:
- Miczek KA, DeBold JF, Hwa LS, Newman EL, de Almeida RM (2015)
Alcohol and violence: Neuropeptidergic modulation of monoamine
systems. Annals of the New York Academy of Sciences 1349:96-118. doi: 10.1111/nyas.12862.
- Albrechet-Souza L, Hwa LS, Han X, Zhang EY, DeBold JF, Miczek KA
(2015) Corticotropin releasing factor binding protein and CRF2
receptors in the ventral tegmental area: Modulation of ethanol
binge drinking in C57BL/6J mice. Alcoholism, Clinical and
Experimental Research 39:1609-1618. doi: 10.1111/acer.12825.
- Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA,
Slonim DK, Bianchi DW (2015) The fetal brain transcriptome and
neonatal behavioral phenotype in the Ts1Cje mouse model of Down
syndrome. American Journal of Medical Genetics, Part A
167A:1993-2008. doi: 10.1002/ajmg.a.37156.
- Burke AR, Miczek KA (2015) Escalation of cocaine
self-administration in adulthood after social defeat of
adolescent rats: Role of social experience and adaptive coping
behavior. Psychopharmacology 232:3067-3079. doi:
- Miczek KA, Takahashi A, Gobrogge KL, Hwa LS, de Almeida RM
(2015) Escalated aggression in animal models: Shedding new light
on mesocorticolimbic circuits. Current Opinion in Behavioral
Sciences 3:90-95. doi:10.1016/j.cobeha.2015.02.007.
- Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B,
Miczek KA, Koide T. (2015) Glutamate input in the dorsal raphe
nucleus as a determinant of escalated aggression in male mice.
The Journal of Neuroscience 35:6452-6463. doi:
- Hwa LS, Nathanson AJ, Shimamoto A, Tayeh JK, Wilens AR, Holly
EN, Newman EL, DeBold JF, Miczek KA (2015) Aggression and
increased glutamate in the mPFC during withdrawal from
intermittent alcohol in outbred mice. Psychopharmacology
232:2889-2902. doi: 10.1007/s00213-015-3925-y.
- Yap JJ, Chartoff EH, Holly EN, Potter DN, Carlezon WA Jr, Miczek
KA (2015) Social defeat stress-induced sensitization and
escalated cocaine self-administration: The role of ERK signaling
in the rat ventral tegmental area. Psychopharmacology
232:1555-1569. doi: 10.1007/s00213-014-3796-7.
- Norman KJ, Seiden JA, Klickstein JA, Han X, Hwa LS, DeBold JF,
Miczek KA (2015) Social stress and escalated drug
self-administration in mice I. Alcohol and corticosterone.
Psychopharmacology 232:991-1001. doi: 10.1007/s00213-014-3733-9.
- Han X, Albrechet-Souza L, Doyle MR, Shimamoto A, DeBold JF,
Miczek KA (2015) Social stress and escalated drug
self-administration in mice II. Cocaine and dopamine in the
nucleus accumbens. Psychopharmacology 232:1003-1010. doi:
- Shimamoto A, Holly EN, Boyson CO, DeBold JF, Miczek KA (2015)
Individual differences in anhedonic and accumbal dopamine
responses to chronic social stress and their link to cocaine
self-administration in female rats. Psychopharmacology
232:825-34. doi: 10.1007/s00213-014-3725-9.
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