| Scholarship & Research: |
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Research interests:
Optical spectroscopy and imaging of turbid media.
Optical study of biological tissue in vivo.
Medical applications of near-infrared spectroscopy and imaging.
Selected patents:
"Optical imaging and oximetry of tissue," Inventor: S. Fantini, Filed: 3/13/2003.
"Method for Measuring Absolute Saturation of Time-Varying and Other Hemoglobin Compartments," Inventors: M. A. Franceschini, S. Fantini, and E. Gratton, U.S. Patent No.6,216,021 (Issued: 4/10/2001).
"Determining Material Concentrations in Tissues," Continuation-in-part of Pat. No.5,497,769, Inventors: E. Gratton, J. S. Maier, M. A. Franceschini, S. Fantini, S. A. Walker, U.S. Patent No.5,492,118 (Issued: 2/20/1996); Canada No. 2,137,878; Europe No.94309361.7; Japan No.332,542/94.
"Photosensor with Multiple Light Sources," Inventors: E. Gratton, S. Fantini, M. A. Franceschini, W. W. Mantulin, B. Barbieri, U.S. Patent No.5,497,769 (Issued: 3/12/1996); Canada No.2,137,878; Europe No.94309361.7; Japan No.332,542/94.
Selected publications:
Y. Tong, J. M. Martin, A. Sassaroli, P. R. Clervil, P. R. Bergethon, and S. Fantini, “Fast optical signals in the peripheral nervous system,” J.
Biomed. Opt. 11, 044014-1 to 044014-5 (2006).
N. Liu, A. Sassaroli, M. A. Zucker, and S. Fantini, “Three-element phased-array approach to diffuse optical imaging based on post-processing of continuous-wave data,” Opt. Lett. 30, 281-283 (2005).
A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49, N255-N257 (2004).
E. L. Heffer, V. E. Pera, O. Schütz, H. Siebold, S. Heywang-Köbrunner, L. Götz, A. Heinig, and S. Fantini, “Near-infrared imaging of the human breast: Complementing hemoglobin concentration maps with oxygenation images,” J. Biomed. Opt. 9, 1152-1160 (2004).
V. Quaresima, M. Ferrari, M. A. Franceschini, M. L. Hoimes, and S. Fantini, “Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy,” J. Biomed. Opt. 9, 413-420 (2004).
F. Fabbri, A. Sassaroli, M. E. Henry, and S. Fantini, "Optical measurements of absorption changes in two-layered diffusive media," Phys. Med. Biol. 49, 1183-1201 (2004).
F. Fabbri, M. E. Henry, P. F. Renshaw, S. Nadgir, B. L. Ehrenberg, M. A. Franceschini, and S. Fantini, "Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy," Brain Research 992, 193-204 (2003).
F. Fabbri, M. A. Franceschini, and S. Fantini, "Characterization of spatial and temporal variations in the optical properties of tissue-like media with diffuse reflectance imaging," Appl. Opt. 42, 3063-3072 (2003).
V. E. Pera, E. L. Heffer, H. Siebold, O. Schütz, S. Heywang-Köbrunner, L. Götz, A. Heinig, and S. Fantini, "Spatial second-derivative image processing: An application to optical mammography to enhance the detection of breast tumors," J. Biomed. Opt. 8, 517-524 (2003).
S. Fantini, "A haemodynamic model for the physiological interpretation of in vivo measurements of the concentration and oxygen saturation of haemoglobin," Phys. Med. Biol. 47, N249-N257 (2002).
E. L. Heffer and S. Fantini, "Quantitative oximetry of breast tumors: A novel near-infrared method that identifies two optimal wavelengths for each tumor," Appl. Opt. 41, 3827-3839 (2002).
D. M. Hueber, M. A. Franceschini, H. Y. Ma, Q. Xu, J. R. Ballesteros, S. Fantini, D. Wallace, V. Ntziachristos, and B. Chance, "Non-Invasive and Quantitative Near-Infrared Hemoglobin Spectrometry in the Piglet Brain During Hypoxic Stress, Using a Frequency-Domain Multi-Distance Instrument," Phys. Med. Biol. 46, 41-62 (2001).
M. A. Franceschini, V. Toronov, M. E. Filiaci, E. Gratton, and S. Fantini, "On-Line Optical Imaging of the Human Brain with 160 ms Temporal Resolution," Opt. Express 6, 49-57 (2000).
S. Fantini and E. Gratton, "Fluorescence Photon-Density Waves in Optically Diffusive Media," Opt. Comm. 173, 73-79 (2000).
S. Fantini, M. A. Franceschini, E. Gratton, D. Hueber, W. Rosenfeld, D. Maulik, P. G. Stubblefield, and M. R. Stankovic, "Non-invasive optical mapping of the piglet brain in real time," Opt. Express 4, 308-314 (1999).
M. A. Franceschini, E. Gratton, and S. Fantini, "Non-Invasive Optical Method to Measure Tissue and Arterial Saturation: an Application to Absolute Pulse Oximetry of the Brain," Opt. Lett. 24, 829-831 (1999).
S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, "Non-Invasive Optical Monitoring of the Newborn Piglet Brain Using Continuous-Wave and Frequency-Domain Methods," Phys. Med. Biol. 44, 1543-1563 (1999).
V. Toronov, M. Filiaci, S. Fantini, and E. Gratton, "Photon-Density Wave Correlation Spectroscopy Detects Large-Scale Fluctuations in Turbid Media," Phys. Rev. E 58, 2288-2297 (1998).
S. Fantini, S. A. Walker, M. A. Franceschini, M. Kaschke, P. M. Schlag, and K. T. Moesta, "Assessment of the Size, Position, and Optical Properties of Breast Tumors in Vivo by Non-Invasive Optical Methods," Appl. Opt. 37, 1982-1989 (1998).
M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, M. Seeber, P. M. Schlag, and M. Kaschke, "Frequency-Domain Instrumentation Enhances Optical Mammography: Initial Clinical Results," Proc. Natl. Acad. Sci. (USA) 94, 6468-6473 (1997).
S. Fantini, M. A. Franceschini, and E. Gratton, "Effective Source Term in the Diffusion Equation for Photon Transport in Turbid Media," Appl. Opt. 36, 156-163 (1997).
J. B. Fishkin, S. Fantini, M. J. vandeVen, and E. Gratton, "Gigahertz Photon Density Waves in a Turbid Medium: Theory and Experiments," Phys. Rev. E 53, 2307-2319 (1996).
S. Fantini, M. A. Franceschini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, K. T. Moesta, P. M. Schlag, and M. Kaschke, "Frequency-Domain Optical Mammography: Edge Effect Corrections," Med. Phys. 23, 149-157 (1996).
S. Fantini, M. A. Franceschini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, "Frequency-Domain Multichannel Optical Detector for Non-Invasive Tissue Spectroscopy and Oximetry," Opt. Eng. 34, 32-42 (1995).
S. Fantini, L. Ulivi, and M. Zoppi, "High Temperature Study of the Raman-Active Phonon Modes of YBa2Cu3O7-x ," Solid State Commun. 93, 519-523 (1995).
S. Fantini, M. A. Franceschini, and E. Gratton, "Semi-Infinite-Geometry Boundary Problem for Light Migration in Highly Scattering Media: a Frequency-Domain Study in the Diffusion Approximation," J. Opt. Soc. Am. B 11, 2128-2138 (1994).
S. Fantini, M. A. Franceschini, J. B. Fishkin, B. Barbieri, E. Gratton, "Quantitative Determination of the Absorption Spectra of Chromophores in Strongly Scattering Media: a Light-Emitting-Diode Based Technique," Appl. Opt. 33, 5204-5213 (1994).
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