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| Name: |
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Klaus A. Miczek |
| Title: |
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Moses Hunt Professor of Psychology, Psychiatry, Pharmacology and Neuroscience
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| Departmental Affiliation: |
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Psychology Department
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| Degrees: |
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Ph.D., University of Chicago, 1972 |
| Expertise: |
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Pharmacology, Aggression, Stress, Anxiety, Drug Abuse
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| Major Awards: |
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Boerhaave-Professorship, Rijksuniversiteit Leiden, The Netherlands, Award for Outstanding Basic Psychopharmacological Research on Affective Disorders, Division of Psychopharmocological and Substance Abuse of the American Psychological Association, Knights Cross of the Order of Merit by the Federal Republic of Germany, Silver Medal, Charles University Medical Faculty, Prague, National Institute on Alcohol Abuse and Alcoholism, MERIT Award |
| E-mail: |
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klaus.miczek@tufts.edu
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| Other websites: |
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http://www.neurosci.tufts.edu/Miczek/
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| Scholarship & Research: |
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Tornatzky, W. and Miczek, K. A. Cocaine self-administration “binges”: transition from behavioral and autonomic regulation toward homeostatic dysregulation in rats. Psychopharmacology 2000 148:289-298
Fish, E. W., Sekinda, M., Ferrari, P. F., Dirks, A. and Miczek, K. A. Distress vocalizations in maternally-separated mouse pups: modulation via 5-HT1A, 5-HT1B and GABAA receptors. Psychopharmacology 2000 149:277-285
Mutschler, N. H., Miczek, K. A. and Hammer, R., Jr. Prolonged reduction of zif/268 mRNA expression during withdrawal following a “binge” of cocaine self-administration. Neuroscience 2000 100:531-538
van Erp, A. M. M. and Miczek, K. A. Aggressive behavior, increased accumbal dopamine and decreased cortical serotonin in rats. Journal of Neuroscience 2000 20:9320-9325
Fischer, H. S., Zernig, G., Schuligoi, R., Miczek, K. A., Hauser, K. F., Gerard, C., Saria, A. Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase ("enkephalinase") gene. Regulatory Peptides 96: 53-58, Sp. Iss. 2000
Fish, E. W., Faccidomo, S., DeBold, J. F. and Miczek, K. A. Alcohol, allopregnanolone and aggression in mice. Psychopharmacology 2001 153:473-483
Mutschler, N. H., Covington, H. E. and Miczek, K. A. Repeated self-administered cocaine “binges” in rats: effects on cocaine intake and withdrawal. Psychopharmacology 2001 154: 292-301
Rowlett, J. K., Tornatzky, W., Cook, J., Ma, C. and Miczek, K. A. Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: differential antagonism by flumazenil and b-CCt. Journal of Pharmacology and Experimental Therapeutics 2001 297:247-253
Votava, M., Krsiak, M., Podhorna, J., and Miczek, K. A. Alprazolam withdrawal and tolerance measured in the social conflict test in mice. Psychopharmacology 2001 157:123-130
de Almeida, R. M., Nikulina, E. M., Faccidomo, S., Fish, E. W. and Miczek, K. A. Zolmitriptan, a 5-HT1B/D receptor agonist, alcohol and aggression in mice. Psychopharmacology 2001 157:131-141
van Erp, A. M. M. and Miczek, K. A. Persistent suppression of ethanol self-administration by brief social stress in rats and increased startle response as index of withdrawal. Physiology & Behavior 2001 73:301-311
van Erp, A.M.M., Tachi, N. and Miczek, K.A. Short or continuous social stress: suppression of continuously available ethanol intake in subordinate rats. Behavioural Pharmacology 2001 12:335-342
Miczek, K. A. and de Almeida, R. M. M. Oral drug self-administration in the home cage of mice: alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline. Psychopharmacology 2001 157:421-429
Covington, H., III and Miczek, K. A. Repeated social defeat stress, cocaine or morphine: effects on behavioral sensitization and IV cocaine self-administration “binges.” Psychopharmacology 2001 158:388-398
Miczek, K. A, Maxson, S. T., Faccidomo, S. and Fish, E. W. Aggressive behavioral phenotypes in mice. Behavioural Brain Research 2001 125:167-181
Miczek, K. A. Research on Animal Aggression: Emerging Successes for Understanding Determinants of Human Violence. In: M. E. Carroll and J. B. Overmier (eds.) Animal Research and Human Health: Advancing Human Welfare Through Behavioral Science. American Psychological Association, Washington D.C. 2001, pp. 41-61
Fish, E.W., DeBold, J.F. and Miczek, K.A. Increased alcohol-heightened aggression following behavioral sensitization to alcohol in mice. Psychopharmacology 2002 160:39-48
de Almeida, R. M. and Miczek, K. A. Aggression escalated by social instigation or by discontinuation of reinforcement (“frustration”) in mice: inhibition by anpirtoline – a 5-HT1B receptor agonist. Neuropsychopharmacology 2002 27:171-181
Dirks, A., Fish, E.W., Kikusui,T., van der Gugten, J., Groenink, L., Olivier, B. and Miczek, K.A. Effects of corticotropin-releasing hormone on distress vocalizations and locomotion in maternally separated mouse pups. Pharmacology Biochemistry and Behavior 2002 72: 993-999
Miczek, K.A., De Bold, J.F., Fish, E.W. and de Almeida, R. M. M. Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at 5-HT, DA and GABA systems. Psychopharmacology 2002 163: 434-458
Fish, E.W., DeBold, J.F. and Miczek, K. A. Aggressive behavior as a reinforcer in mice: activation by allopregnanolone. Psychopharmacology 2002 163: 459-466
Ferrari, P.F., van Erp, A.M.M., Tornatzky, W., and Miczek, K.A. Accumbal dopamine and serotonin in anticipation of the next aggressive episode in rats. European Journal of Neuroscience 2003 17: 371-378
Covington, H., III and Miczek, K. A. Vocalizations during withdrawal from opiates and cocaine: Possible expressions of affective distress. European Journal of Pharmacology 2003 467: 1-13
McKenzie-Quirk S. D., and Miczek K. A. 5-HT1A agonists: alcohol drinking in rats and squirrel monkeys. Psychopharmacology 2003 167:145-152
Miczek, K. A., Fish, E. W. and DeBold, J. F. Allopregnanolone, GABAA receptors, and escalated aggression. Hormones and Behavior 2003 44:242-257
Fish, E. W., Faccidomo, S., Gupta, S., and Miczek, K. A. Anxiolytic-like effects of escitalopram and its enantiomers, citalopram and R-citalopram in maternally separated mouse pups. Journal of Pharmacology and Experimental Therapeutics 2004 308:474-480
Nikulina, E., Covington, H. III, Hammer, R.J., Jr. and Miczek, K. A. Long-term behavioral and neural cross-sensitization to amphetamine induced by repeated social defeat stress. Neuroscience 2004 123:857-865
Miczek, K. A., Covington, H. III, Nikulina, E. M., Hammer, R. P., Jr. Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits. Neuroscience and Biobehavioral Review 2004 27: 787-802
de Almeida, R. M. M., Rowlett, J. K., Cook, J., W. Yin and Miczek, K. A. GABAA/a1 receptor agonists and antagonists, and alcohol-heightened aggressive behavior in mice. Psychopharmacology 2004 172:255-263
Miczek, K. A., Fish, E. W., de Almeida, R. M. M., Faccidomo, S., DeBold, J. F. Role of alcohol consumption in escalations to violence. Devine, J., Gilligan, J., Miczek K.A., Pfaff, D., Shaikh, R. (eds.) Youth Violence. Scientific Approaches to Prevention. Annals of New York Academy of Sciences 2004 1036:278-289
Miczek, K. A., Faccidomo, S., de Almeida, R. M. M. , Bannai, M., Fish, E. W., and DeBold, J. F. Escalated aggressive behavior: new pharmacotherapeutic approaches and opportunities. Devine, J., Gilligan, J., Miczek K.A., Pfaff, D., Shaikh, R. (eds.) Youth Violence. Scientific Approaches to Prevention. Annals of New York Academy of Sciences 2004 1036:336-355
Covington, H. III, Kikusui, T., Goodhue, J., Nikulina, E., Hammer, R.J., Jr., and Miczek, K. A. Social defeat stress, cocaine binges, and persistent changes in zif268 expression in amygdala and prefrontal cortex. Neuropsychopharmacology 2005 29:1-12
Gourley, S. L., DeBold, J. F., W. Yin, Cook, J., and Miczek, K. A. Benzodiazepines and heightened aggressive behavior in rats: reduction by GABAA/a1 receptor antagonists. Psychopharmacology 2005 178:232-240
Kikusui, T., Faccidomo, S. and Miczek, K. A. Repeated maternal separation increases cocaine-induced behavioral sensitization in adult male and female mice. Psychopharmacology 2005 178:202-210
Miczek, K. A., Nikulina, E. M., Covington, H. III, and Hammer, R. P., Jr. Social conflict: gene expression in aminergic and peptidergic cells during aggression and defeat. In: S. Maxson and R. Buck (eds.) Festschrift for Benson E. Ginsburg. American Psychological Association, Washington D.C. 2005, pp.
Miczek, K. A. and S. F. de Boer Aggressive, defensive and submissive behavior. In: Ian Q. Wishaw and Bryan Kolb (eds.) The Behaviour of the Laboratory Rat: A Handbook with Tests, Oxford University Press 2005, pp. 344-352
Miczek, K. A. and E. W. Fish Dopamine, glutamate and aggression. In: Werner J. Schmidt and Maarten E. A. Reith (eds.) Dopamine and glutamate in psychiatric disorders. The Humana Press 2005, pp.
Miczek, K. A. and E. W. Fish Monoamines, GABA, Glutamate and Aggression. In: Randy J. Nelson (ed.) Biology of Aggression. Oxford University Press 2005
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