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| Name: |
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Irene Georgakoudi |
| Title: |
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Assistant Professor
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| Departmental Affiliation: |
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Biomedical Engineering Department
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| Degrees: |
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1993-BA Physics Dartmouth College;
1996-MSc Biophysics University of Rochester;
1999-PhD Biophysics University of Rochester |
| Expertise: |
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Biomedical Optics
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| Major Awards: |
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1999-2002 National Research Service Award, U.S. National Institutes of Health., 2004 Claflin Distinguished Scholar Award, Massachusetts General Hospital, Harvard Medical School., 2005 Inaugural Sturge Price awarded for “pioneering contributions to spectral diagnosis of biological materials using optical spectroscopic methodology.” |
| E-mail: |
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Irene.Georgakoudi@tufts.edu
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| Other websites: |
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http://ase.tufts.edu/biomedical/faculty-staff/georgakoudi.asp
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| Scholarship & Research: |
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Research Interests:
Development of novel optical, non-invasive technologies for disease detection;
Spectroscopic confocal/multi-photon imaging of tissue interactions;
Optical imaging of engineered tissues
Peer reviewed articles:
1. Georgakoudi I, Nichols MG and Foster TH. The mechanism of Photofrin photobleaching and its consequences for photodynamic dosimetry. Photochem. Photobiol. 1997; 65: 135-144.
2. Georgakoudi I and Foster TH. Singlet oxygen- versus nonsinglet oxygen-mediated mechanisms of sensitizer photobleaching and their effects on photodynamic dosimetry. Photochem. Photobiol.1998; 67: 612-62.
3. Georgakoudi I and Foster TH. Effects of the subcellular redistribution of two nile blue derivatives on photodynamic oxygen consumption. Photochem. Photobiol. 1998; 68: 115-122.
4. Georgakoudi I, Keng PC and Foster TH. Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells. Br. J. Cancer 1999; 79: 1372-1377.
5. Yang C, Wax A, Georgakoudi I, et al. Interferometric phase-dispersion microscopy. Opt Letters 2000; 25: 1526-1528.
6.Georgakoudi I, Jacobson BC, Van Dam J et al. Fluorescence, reflectance and light scattering spectroscopy for evaluating dysplasia in patients with Barrett’s esophagus. Gastroenterology 2001; 120: 1620-1629.
7. Bigelow CE, Harkrider CJ, Conover DL, Foster TH, Georgakoudi I, Mitra S, Nichols MG and Rajadhyaksha M. Retrofit design and implementation of confocal scanning using a commercial inverted fluorescence microscope platform. Review of Scientific Instruments 2001; 72: 3407-3410.
8.Müller MG, Georgakoudi I, Zhang Q, Wu J and Feld MS. Intrinsic fluorescence spectroscopy in turbid media: Disentangling effects of scattering and absorption. Applied Optics 2001; 40: 4633-4646.
9. Gurjar R, Backman V, Perelman LT, Georgakoudi I, Badizadegan K, Itzkan I, Dasari R and Feld MS. Functional imaging of human epithelia with polarized light scattering spectroscopy. Nature Medicine 2001; 7: 1245-1248.
10. Backman V, Gopal V, Kalashnikov M, Badizadegan K, Gurjar R, Wax A, Georgakoudi I, Mueller M, Boone CW, Dasari RD and Feld MS. Measuring cellular structure at submicron scale with light scattering spectroscopy. IEEE J Sel Top Quantum Electron 2001; 7: 887-893.
11. Georgakoudi I, Jacobson BC, Mueller MG, et al. NAD(P)H and collagen as quantitative fluorescent biomarkers of epithelial precancerous changes. Cancer Research 2002; 62: 682-687.
12. Georgakoudi I, Sheets EE, Mueller M, Backman V, Crum CP, Badizadegan K and Feld MS. Tri-modal spectroscopy as a tool for the detection and biochemical/morphological characterization of cervical pre-cancers in vivo. American Journal of Obstetrics and Gynecology 2002; 186: 374-382.
13. Mueller M, Wax A, Georgakoudi I, Galindo L, Dasari R, Feld M. Multiexcitation fluorescence and reflectance portable spectrofluorimeter to assist real time guidance to biopsy in precancer screening. Review of Scientific Instruments 2002; 73: 3933-393.
14. Mueller M, Valdez T, Georgakoudi I, et al. Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma. Cancer 2003; 97:1681-1692.
15. Novak J, Georgakoudi I, Wei X, Prossin A, Lin C. An in vivo flow cytometer for real-time detection and quantification of circulating cells. Opt Lett 2004, 29: 77-79.
16. Georgakoudi I. Solban N, Novak J et al. In vivo flow cytometry: A new method for enumerating circulating cancer cells. Cancer Res 2004, 64:5044-5047.
Invited reviews:
1. Georgakoudi I and Van Dam J. Characterization of Dysplastic Tissue Morphology and Biochemistry in Barrett’s Esophagus Using Diffuse Reflectance and Light Scattering Spectroscopy. Gastrointest Endosc Clin North Am 2003; 13:297-308.
2. Georgkoudi I and Feld MS. Intrinsic Fluorescence, Diffuse Reflectance and Light Scattering for Detecting Dysplasia in Barrett’s Esophagus. Gastrointest Endosc Clin North Am 2004, 14: 519-537.
Book Chapters:
1. Georgakoudi I, Motz J,, Backman V, Angheloiu G, Haka A, Müller M, Dasari R and Feld MS. Quantitative characterization of biological tissue using optical spectroscopy. In the Biomedical Photonics Handbook, ed. Tuan Vo-Dinh, CRC Press: Boca Raton, FL. 2003;chapter 31, pp.1-33.
2. Georgakoudi I, Müller M and Feld MS. Intrinsic Fluorescence Spectroscopy of Biological Tissue. In Fluorescence in Biomedicine, ed. Mary-Ann Mycek and Brian Pogue, Marcel Dekker, Inc: New York. 2003; chapter 4, pp. 109-142.
Patents:
1. Georgakoudi I, Backman V and Feld MS. Flourescence, Reflectance and Light Scattering Spectroscopy for Measuring Tissue. MIT assignee. U.S. Patent No.: 6,697,652. Issue date: Feb 24, 2004
2. Georgakoudi I, Feld MS, Zhang Q and Mueller M. System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics. MIT assignee. Pub. No:
US2003/0013973. Pub. Date: Jan 16, 2003
3. Foster T, Conover D, Bigelow C, Georgakoudi I, Mezhiba A, Mitra S. A method for operating a laser scanning confocal microscope system and a system thereof. University of Rochester assignee. U.S. Patent No. 6,859,273. Issue date: February 22, 2005
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