Faculty Profiles
Tufts University Arts, Sciences and Engineering
 
Name: David Cochrane
Title: Professor of Biology
Departmental Affiliation: Biology Department
Degrees: Ph.D. University of Vermont; M.S. University of Vermont; B.S. Cornell University
Expertise: Physiology of the Mast cell
Neural-endocrine-immune Interactions
Inflammation
E-mail: david.cochrane@tufts.edu

Other websites: http://ase.tufts.edu/biology/faculty/cochrane
Scholarship & Research: Richard C. Scarpa, Robert E. Carraway, and David E. Cochrane Insulin-like growth factor (IGF) induced proliferation of human lung fibroblast is enhanced by neurotensin Peptides, 2005 in press

Richard C. Scarpa, Robert E. Carraway, and David E. Cochrane The effect of neurotensin on insulin-induced proliferation of human fibroblasts Peptides, 2004, 25, 1159-1169

Theoharides, T.C, and D.E.Cochrane Critical role of mast cells in neuroinflammatory disease J. Neuroimmunology 2004 146, 1-12

Carraway RE, Hassan S, Cochrane D.E. Polyphenolic antioxidants mimic the effects of 1,4-dihydropyridines on neurotensin receptor function in PC3 cells. J Pharmacol Exp Ther. 2004 309, 92-101

Caraway, R.E., Gui, X. and Cochrane, D.E. Ca 2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells. J. Pharmacol. Exp Therapeutics 2003 ;307; 640-650

Cochrane,D.Eb Carraway, R.E. aMiller L.A., aFeldbergR.S. and aBernheim, H. Histamine-Releasing Peptide (HRP) has proinflammatory effects and is present at sites of inflammation. Biochem. Pharmacol. 2003; 66 331-342

Pechenik JA, Wei LI, Cochrane DE Timing is everything: The effects of putative dopamine antagonists on metamorphosis vary with larval age and experimental duration in the Prosobranch gastropod Crepidula fronicata. Biol. Bul. 2002, 202: 137-147.

Harris MT, Feldberg RS, Lau KM, Lazarus NH, Cochrane D.E. Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Prostate. 2000 Jun 15;44(1):19-25.

Alexacos N, Pang X, Boucher W, Cochrane DE, Sant GR, Theoharides TC. Neurotensin mediates rat bladder mast cell degranulation triggered by acute psychological stress.Urology. 1999 May;53(5):1035-1040.

Barrocas AM, Cochrane DE, Carraway RE, Feldberg RS. Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C. Immunopharmacology. 1999 Feb;41(2):131-137.

Feldberg RS, Cochrane DE, Carraway RE, Brown E, Sawyer R, Hartunian M, Wentworth D. Evidence for a neurotensin receptor in rat serosal mast cells. Inflamm Res. 1998 Jun;47(6):245-250.

Miller LA, Cochrane DE, Feldberg RS, Carraway RE. Inhibition of neurotensin-stimulated mast cell secretion and carboxypeptidase A activity by the peptide inhibitor of carboxypeptidase A and neurotensin-receptor antagonist SR 48692. Int Arch Allergy Immunol. 1998 Jun;116(2):147-153.

Miller LA, Cochrane DE, Carraway RE, Feldberg RS. Blockade of mast cell histamine secretion in response to neurotensin by SR 48692, a nonpeptide antagonist of the neurotensin brain receptor. Br J Pharmacol. 1995 Apr;114(7):1466-1470.

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