| Scholarship & Research: |
 |
Freudenreich, C. H. (2007) Chromosome Fragility: Molecular mechanisms and cellular consequences. Frontiers in Bioscience (in press) (review for special edition "DNA Structures, Genome Instability and Human Disease")
Yang, J. and Freudenreich, C.H. (2007) Haploinsufficiency of yeast
FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner. Gene, Volume 393, Issues 1-2, 15 May 2007, Pages 110-115.
Freudenreich, C. H. (2005) Molecular Mechanisms of Chromosome Fragility.
ChemTracks-Biochemistry and Molecular Biology, Vol 18, No.3, March 2005 (invited review for special theme issue “Unstable Microsatellites in the Human Genome, Part 2”.)
C. H. Freudenreich and Mayurika Lahiri (2004) Structure-Forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: Implications for trinucleotide repeat expansion diseases. Cell Cycle Vol 3 (11) 1370-1374.
Lahiri M., Gustafson T.L., Majors E.R., Freudenreich C.H. (2004) Expanded CAG repeats Activate the DNA Damage Checkpoint Pathway. Mol Cell 15, 287-293.
Liu Y., Zhang H., Veeraraghavan J., Bambara R.A., Freudenreich C.H. 2004 Saccharomyces cerevisiae Flap Endonuclease 1 Uses Flap Equilibration to Maintain Triplet Repeat Stability. Mol Cell Biol. 24: 4049-4064.
Callahan JL, Andrews KJ, Zakian VA, Freudenreich CH. 2003 Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol Cell Biol. 23:7849-60.
Lenzmeier BA, Freudenreich CH. 2003 Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repair. Cytogenet Genome Res. 100(1-4):7-24.
Balakumaran, B. S., Freudenreich, C. H., and Zakian, V. A. (2000) “CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae.” Human Molecular Genetics 9: 93-100.
Freudenreich, C. H., Kantrow, S. M., and Zakian, V. A. (1998) “Expansion and Length-Dependent Fragility of CTG Repeats in Yeast.” Science 279: 853-856.
Freudenreich, C. H., Stavenhagen, J. B. and Zakian, V. A. (1997) “Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome.” Molecular and Cellular Biology, 17: 2090-2098.
|