Recent Publications

2010

"Bead-based optical fiber arrays for artificial olfaction"
Walt, David R. Current Opinion in Chemical Biology (2010) 14(6), 767-770.

"Optical sensing arrays for single-cell analysis"
Whitaker, Ragnhild D.; Walt, David R.. Chemical Cytometry (2010) 219-237.

"Visualizing Fluorescence: Using a Homemade Fluorescence "Microscope" To View Latent Fingerprints on Paper"
LaFratta, Christopher N.; Huh, Sun Phill; Mallillin, Allistair C.; Riviello, Peter J.; Walt, David R.. Journal of Chemical Education (2010) 87(10), 1105-1107.

"Analytical chemistry on the femtoliter scale"
Gorris, Hans H.; Walt, David R.. Angewandte Chemie, International Edition (2010) 49(23), 3880-3895.

"Synthesis and biological testing of penicillins: an investigative approach to the undergraduate teaching laboratory"
Whitaker, Ragnhild D.; Truhlar, Laura M.; Yuksel, Deniz; Walt, David R.; Williams, Mark D. Journal of Chemical Education (2010) 87(6), 634-636.

"Toward multiple addressable optical trapping"
Faustov, Alexei R.; Webb, Michael R.; Walt, David R.. Review of Scientific Instruments (2010) 81(2, Pt. 1), 026109/1-026109/3.

"Fibre Optic Microarrays"
Walt, David R. Chemical Society Reviews (2010) 39(1), 38-50.

 

2009

"Optical-fiber arrays for vapor sensing"
Aernecke, Matthew J.; Walt, David R. Sensors and Actuators, B: Chemical
(2009) B142(2), 464-469.


"
Ubiquitous Sensors: When Will They Be Here?"
Walt, David R. ACS Nano (2009) 3(10), 2876-2880
.

"Infochemistry and infofuses for the chemical storage and transmission of coded information"
Thomas, Samuel W., III; Chiechi, Ryan C.; Lafratta, Christopher N.; Webb, Michael R.; Lee, Andrew; Wiley, Benjamin J.; Zakin, Mitchell R.; Walt, David R.; Whitesides, George M. Proceedings of the National Academy of Sciences of the United States of America 
(2009) 106(23), 9147-9150
.

"CMOS microelectrode array for electrochemical lab-on-a-chip applications"
Hwang, Sungkil; La Fratta, Christopher N.; Agarwal, Vinay; Yu, Xin; Walt, David R.; Sonkusale, Sameer. IEEE Sensors Journal (2009), 9(6), 609-615.

"Intelligent Medical Diagnostics via Molecular Logic"
Konry, Tania; Walt, David R. Journal of the American Chemistry Society
(2009) 131(37), 13232-13233.

"Chromatically Resolved Optical Microscope (CROMoscope): A Grating-Based Instrument for Spectral Imaging"
Webb, Michael R.; LaFratta, Chris N.; Walt, David R. Analytical Chemistry
(2009) 81(17), 7309-7313.

"Microsphere-Based Rolling Circle Amplification Microarray for the Detection of DNA and Proteins in a Single Assay"
Konry, Tania; Hayman, Ryan B.; Walt, David R. Analytical Chemistry (2009) 81(14), 5777-5782.

"Temporally Resolved Fluorescence Spectroscopy of a Microarray-Based Vapor Sensing System"
Aernecke, Matthew J.; Walt, David R. Analytical Chemistry
(2009) 81(14), 5762-5769.

Design, Implementation, and Field Testing of a Portable Fluorescence-Based Vapor Sensor
Aernecke, Matthew J.; Guo, Jian; Sonkusale, Sameer; Walt, David R. Analytical Chemistry
(2009), 81(13), 5281-5290.

Multiplexed Sandwich Immunoassays Using Electrochemiluminescence Imaging Resolved at the Single Bead Level
Deiss, Frederique; La Fratta, Christopher N.; Symer, Matthew; Blicharz, Timothy M.; Sojic, Neso; Walt, David R. Journal of the American Chemical Society (2009), 131(17), 6088-6089.

"DNA detection on ultrahigh-density optical fiber-based nanoarrays"
Tam, Jenny M.; Song, Linan; Walt, David R. Biosensors & Bioelectronics (2009), 24(8), 2488-2493.

Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies
Gorris, Hans H.; Walt, David R. Journal of the American Chemical Society (2009) 131(17), 6277-6282.

"Fiber-Optic Microsphere-Based Antibody Array for the Analysis of Inflammatory Cytokines in Saliva"
Blicharz, Timothy M.; Siqueira, Walter L.; Helmerhorst, Eva J.; Oppenheim, Frank G.; Wexler, Philip J.; Little, Frederic F.; Walt, David R. Analytical Chemistry (2009), 81(6), 2106-2114.

 

2008

Detection of single-molecule DNA hybridization using enzymatic amplification in an array of femtoliter-sized reaction vessels
Z. Li, R.B. Hayman, D.R. Walt, Journal of the American Chemical Society 2008 130 (38), 12622-12623

"Distinct and Long-lived Activity States of Single Enzyme Molecules"
D.M. Rissin, H.H. Gorris, D.R. Walt, JACS, 2008 130 (15), 5349-5353
            News highlights about this article:
           "Distinctive Individualism", Science, Editors' Choice April 2008, 320 (5872), p. 23

"Very High Density Sensing Arrays"
Christopher N. LaFratta and David R. Walt, Chem. Rev., 2008 108 (2), 614 - 637 (review)

"Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle"
Blicharz, Timothy M.; Rissin, David M.; Bowden, Michaela; Hayman, Ryan B.; DiCesare, Christopher; Bhatia, Jasvinder S.; Grand-Pierre, Nerline; Siqueira, Walter L.; Helmerhorst, Eva J.; Loscalzo, Joseph; Oppenheim, Frank G.; Walt, David R., Clinical Chemistry, (2008), 54(9), 1473-1480.

 

2007

Fiber-based Single Cell Analysis of Reporter Gene Expression in Yeast Two-hybrid Systems
R.D. Whitaker, D.R. Walt. Analytical Biochemistry , 2007 360, 63-74

Stochastic Inhibitor Release and Binding from Single-enzyme Molecules
H.H. Gorris, D.M. Rissin, D.R. Walt, PNAS, 2007, 104 (45), 17680-17685
            News highlights about this article:
            a) “
Observing Single Enzymes at Work”, Chem. Eng. News, 2007, 85 (44), 8
            b) “
High-throughput, Single-enzyme Assay System”, Anal. Chem., 2008, 80 (1), 5

"Optical-fiber Bundles"
H.H. Gorris, T.M. Blicharz, D.R. Walt, FEBS Journal, 2007, 274 (21), 5462-5470 (review)

"Microsensor Arrays for Saliva Diagnostics"
T.M. Blicharz, R.B. Hayman, D.M. Rissin, M. Bowden, W.L. Siqueira, E.J. Helmerhorst, N. Grand-Pierre, F.G. Oppenheim, J.S. Bhatia, F.F. Little, J.S. Brody, D.R. Walt, Ann N Y Acad Sci. , 2007 1098, 389-400.

"Smells Like Bread"
D.R. Walt, Nature Chemical Biology, 2007 3(6), 325-330

 

2006

"Fiber Optic Array Biosensors"
D.R. Walt, Biotechniques , 2006 41(5), 529-535

Microbead Chemical Switches: An Approach to Detection of Reactive Phosphonate Chemical Warfare Agent Vapors
S. Bencic-Nagale, T. Sternfeld, D.R. Walt. JACS, 2006 128 (15), 5041-5048

Digital Readout of Target Binding with Attomole Detection Limits via Enzyme Amplification in Femtoliter Arrays
D.M. Rissin, D.R. Walt, JACS, 2006 128 (19), 6286-6287

............News highlight about this article:
............
Single-molecule Binding Assay in Femtoliter Arrays, Anal. Chem., 2006, 78 (13), 4241

Duplexed Sandwich Immunoassays on a Fiber-optic Microarray
D.M. Rissin, D.R. Walt. Analytica Chimica Acta, 2006 564 (1), 34-39

Fiber-Optic Microsphere-Based Arrays for Multiplexed Biological Warfare Agent Detection
L. Song, S. Ahn, D.R. Walt. Analytical Chemistry, 2006 78 (4),1023-1033

Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics
D.M. Rissin, D.R. Walt. Nano Letters 2006 6 (3), 520-523

 

2005

Extending the Longevity of Fluorescence-Based Sensor Arrays Using Adaptive Exposure
S. Bencic-Nagale, D.R. Walt. Analytical Chemistry, 2005 77, 6155-6162

Simultaneous Detection of Multiple Biological Warfare Agents in Environmental Samples Using Fiber-Optic Microsphere-Based Arrays
L. Song, S. Ahn, D.R. Walt. Emerging Infectious Diseases, 2005 11, 1629-1632

Development of a Microfluidic Platform with an Optical Imaging Microarray Capable of Attomolar Target DNA Detection
M. Bowden, L. Song, D.R. Walt. Analytical Chemistry, 2005 77 (17), 5583-5588

Fabrication and Optical Characterization of Imaging Fiber Based Nanoarrays
J. Tam, L. Song, D.R. Walt. Talanta, 2005 67 (3), 498-502

Monitoring "promiscuous" drug effects on single cells of multiple cell types
Y. Kuang, D.R. Walt. Analytical Biochemistry, 2005 345, 320-325

Optical Fiber-based Sensors: Application to Chemical Biology
K.L. Brogan, D.R. Walt, Current Opinion in Chemical Biology, 2005, 9, 494-500.

Advances in Miniature Analytical Methods for Medical Diagnostics
D.R. Walt, Science , 2005, 308, 217-219.

Editorial: "Electronic Noses: Wake Up and Smell the Coffee
D.R. Walt, Analytical Chemistry A-Pages, 2005, 77 (3), 45A.

Array-based Binary Analysis for Bacterial Typing
J. E. Shepard, Y. Danin-Poleg, Y. Kashi, D.R. Walt, Analytical Chemistry, 2005 , 77 , 319-326.

 

2004

Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays
Y. Kuang, I. Biran, D.R. Walt, Analytical Chemistry, 2004, 76 (21), 6282-6286.

Fabrication of Gold Microtubes and Microwires in High Aspect Ratio Capillary Arrays
D. Monk, D.R. Walt, JACS , 2004, 126 (37), 11416-11417.

Optical Fiber-Based Biosensors
D. Monk, D.R. Walt, Analytical and Bioanalytical Chemistry, 2004, 379 , 931-945.

Living Bacterial Cell Array for Genotoxin Monitoring
Y. Kuang, I. Biran, D.R. Walt, Analytical Chemistry, 2004, 76, 2902-2909.

Reversible Ratiometric Probe for Quantitative DNA Measurements
D.R. Walt and J. Ueberfeld, Analytical Chemistry, 2004, 76 (4), 947-952.

 

2003

Combinatorial Decoding: An Approach for Universal DNA Array Fabrication
J. Epstein, J. Ferguson, K. Lee, D.R. Walt, JACS , 2003, 125 , 13753-13759.

The Use of Optical Fiber Bundles Combined with Electrochemistry and Chemical Imaging
S. Szunerits and D.R. Walt, Chemphyschem , 2003 (4), 186-192.

Spatially resolved electrochemiluminescence on an array of electrode tips
S. Szunerits, J. Tam, L. Thouin, C. Amatore, and D.R. Walt, Anal. Chem ., 2003, 75 , 4382-4388.

Optical Imaging Fiber Based Live Bacterial Cell Array Biosensor"
I. Biran, D. M. Rissin, E.Z. Ron, and D.R. Walt, Anal. Biochem., 2003, 315 (1), 106-113.

Fluorescence-based Fibre Optic Arrays: A Universal Platform for Sensing
D.R. Walt and J. Epstein, Chem. Soc. Reviews, 2003, (32), 203-214.

Encoded Fiber Optic Microsphere Arrays for Probing Protein-Carbohydrate Interactions
E. Adams, J. Ueberfeld, D. Ratner, B. O'Keefe, D.R. Walt, P. Seeberger, Angewandte Chemie , 2003 (115), 5475-5478.

 

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