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Tufts University

Department of Chemistry

62 Talbot Avenue
Medford, MA 02155
(617) 627-3441

The Kritzer Laboratory

 

Publications:

Diversity-oriented stapling yields intrinsically cell-penetrant inducers of autophagy Leila Peraro, Zhongju Zou, Kamlesh M. Makwana, Ashleigh Cummings, Haydn L Ball, Hongtao Yu, Yu-Shan Lin, Beth Levine, and Joshua A Kritzer. Journal of the American Chemical Society, Just Accepted, DOI: 10.1021/jacs.7b01698.

Selected as an ACS Editor's Choice for May 9, 2017! Featured on the cover of the June 14 issue!

Identifying Loop-Mediated Protein-Protein Interactions Using LoopFinder. Timothy R. Siegert, Michael J. Bird, and Joshua A. Kritzer. Methods in Molecular Biology, 1561, 255-277 (2017).

A Reverse Science Fair that Connects High School Students with University Researchers Brian Mernoff, Amanda R. Aldous, Natalie A. Wasio, Joshua A. Kritzer, E. Charles H. Sykes, and Karen O'Hagan. Journal of Chemical Education, 94, 171-176 (2017).

Analysis of Loops that Mediate Protein-Protein Interactions and Translation into Sub-Micromolar Inhibitors. Timothy R. Siegert, Michael J. Bird, Kamlesh M. Makwana and Joshua A. Kritzer. Journal of the American Chemical Society, 138, 12876-12884 (2016).

Conformational Restriction of Peptides Using Dithiol Bis-Alkylation. Leila Peraro, Timothy R. Siegert, and Joshua A. Kritzer. Methods in Enzymology, 580, 303-332 (2016).

(News and Views) Stapled peptides: How to be quick on the uptake. Joshua A. Kritzer. Nature Chemical Biology, 12, 764-765 (2016).

Designing Convergent Chemistry Curricula. Louise K. Charkoudian, Nicole S. Sampson, Krishna Kumar, and Joshua A. Kritzer. Nature Chemical Biology, 12, 382-386 (2016).

A Bicyclic Peptide Scaffold Promotes Phosphotyrosine Mimicry and Cellular Uptake. Justin S. Quartararo, Matthew R. Eshelman, Leila Peraro, Hongtao Yu, James D. Baleja, Yu-Shan Lin, and Joshua A. Kritzer. Bioorganic and Medicinal Chemistry, 22, 6387-6391 (2014).

Solution structure of a designed cyclic peptide ligand for nickel and copper ions
Matthew R. Eshelman, Amanda R. Aldous, Kosh P. Neupane, and Joshua A. Kritzer. Tetrahedron, 70, 7651-7654 (2014).
Part of a special issue on Peptide Macrocycles.

Comprehensive Analysis of Loops at Protein-Protein Interfaces for Macrocycle Design.
Jason Gavenonis*, Bradley S. Sheneman*, Timothy R. Siegert*, Matthew R. Eshelman, and Joshua A. Kritzer. Nature Chemical Biology, 10, 716-722 (2014).
*these authors contributed equally to this work
Read the News and Views!

Structured Cyclic Peptides that Bind the EH Domain of EHD1.
Alissa Kamens, Robyn J. Eisert, Tiffany Corlin, James D. Baleja, and Joshua A. Kritzer. Biochemistry, 53, 4758-4760 (2014).

Potential C-terminal-domain Inhibitors of Heat Shock Protein 90 Derived from a C-terminal Peptide Helix.
Jason Gavenonis, Nicholas E. Jonas, and Joshua A. Kritzer. Bioorganic and Medicinal Chemistry, 22, 3989-3993 (2014).

Metal-Binding and Redox Properties of Substituted Linear and Cyclic ATCUN Motifs.
Kosh P. Neupane, Amanda R. Aldous, and Joshua A. Kritzer. Journal of Inorganic Biochemistry 139, 65-76 (2014).

Versatile Substrates and Probes for IgA1 Protease Activity
Santosh K. Choudary, Jiazhou Qiu, Andrew G. Plaut, Joshua A. Kritzer. ChemBioChem. 14, 2007-2012 (2013).

Macrocyclization of the ATCUN Motif Controls Metal Binding and Catalysis
Kosh P. Neupane, Amanda R. Aldous, and Joshua A. Kritzer.
Inorg. Chem. 52, 2729-2735 (2013).

(Review)
Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints
Jonathan E. Bock, Jason Gavenonis, and Joshua A. Kritzer. ACS Chem. Biol. 8, 488-499 (2013).

Peptide Bicycles that Inhibit the Grb2 SH2 Domain
Justin S. Quartararo, Pianpian Wu and Joshua A. Kritzer. ChemBioChem 13, 1490-1496 (2012).
See the inside cover!

(Perspective)
Beyond discovery: probes that see, grab and poke
Joshua A. Kritzer.
Nat. Chem. Biol. 6, 868-870 (2010).

(News and Views)
Stapled peptides: Magic bullets in nature's arsenal
Joshua A. Kritzer.
Nat. Chem. Biol. 6, 566-567 (2010).

 

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models
Joshua A. Kritzer, Shusei Hamamichi, J. Michael McCaffery, Sandro Santagata, Todd A. Naumann, Kim A. Caldwell, Guy A. Caldwell, and Susan Lindquist.
Nat. Chem. Biol. 5, 655-663 (2009).