CHBE 101 - Mathematical Methods in Chemical Engineering

Application of numerical methods and digital computers to the solution of mathematical problems in chemical engineering. Subjects include interpolation and approximation, roots of algebraic equations, plus numerical integration and solution to ordinary and partial differential equation. For juniors, seniors, and graduate students.

 

CHBE 102 - Chemical Reactor Design

Treatment of chemical reaction equilibrium and kinetic fundamentals and application of them to the design of reactors. Topics include interpretation of reaction-rate data, establishment of reaction mechanism and rate-controlling steps, sizing and optimizing of reactors. Use of digital computers is encouraged.

 

CHBE 103 - Chemical and Catalytic Reaction Engineering
Prerequisite: Chemical Engineering 102

Application of chemical kinetics to the development and improvement of industrial processes; theories of chemical kinetics, complex kinetics, chain reactions; isothermal and polytropic reactor stability; stability criteria; oscillatory catalytic and non-catalytic reactions.

 

CHBE 104 - Separation Processes
Prerequisites: Chemical Engineering 23

Material on mass-transfer separation processes beyond that covered by the undergraduate unit operations course. Stage-wise process of distillation, extraction and absorption. Computational techniques employing digital computers are emphasized.

 

CHBE 107 - Membrane Separations
Prerequisites: Consent

This course introduces the science, technology and applications of membrane separation processes. Coverage includes fundamentals of transport in porous and non-porous membrane materials, formation of membranes, and basic design of the most important membrane processes. The major processes include microfiltration, ultrafiltration, reverse osmosis, dialysis, and gas separation. This essentially practical course is biased towards membrane bioseparations and specialized topics include membrane fouling issues and controlled release.

 

CHBE 109 - Process Dynamics and Control
Prerequisites: Chemical Engineering 21 and 22, or consent

Mathematical modeling of chemical processes with ordinary differential equations. Feedback, feedforward and environmental control. Block diagrams. Laplace transformations. Linearization techniques. Frequency response. Laboratory exposure to instrumentation.

 

CHBE 110 - Optimization

Introduction to fundamentals of optimization and operations research. Need for identifying the objective function to be maximized or minimized, along with the imposed constraints, is stressed. Familiarity and skills with several optimization techniques, with emphasis on linear and dynamic programming, are developed.

 

CHBE 111 - Computational Methods in Chemical and Biological Engineering

Introduction to numerical methods and commercially available software for modeling of chemical and biological processes. Case studies will include chemical reactors and metabolism.

 

CHBE 112 - Advanced Heat Transfer (Co-listed with ME 112)
Prerequisites: Chemical Engineering 22

 

CHBE 114 - Advanced Transport Phenomena
Prerequisite: Chemical Engineering 23 Heat, mass and momentum transfer beyond Chemical Engineering 23.

Emphasis on coupling among transport processes and with chemical reaction. Problems of industrial and biological interest.

 

CHBE 121 - Principles of Polymerization
Prerequisites: Physical Chemistry, Organic Chemistry Synthesis of polymeric materials considered.

Three major types of polymerizations; step, chain, and ring-opening are reviewed with emphasis on reaction mechanisms, kinetics, thermodynamics aspects of the reactions and their relationships to molecular weight and molecular structures of macromolecules.

 

CHBE 122 - Physical Chemistry of Polymers
Prerequisites: Chemistry 31

Physi-chemical properties of polymeric materials with emphasis on the relationship between molecular architecture and physical properties. Topics include polymer solution theories, thermal transitions, conformational analysis, polymer microstructure, crystallinity and morphology, the rubbery and glassy states, rheology, and statistical thermodynamics.

 

CHBE 135 - Advanced Thermodynamics
Prerequisite: Chemical Engineering 42 or equivalent

Thermodynamics as applied to chemical engineering. Attention is given to the derivation of thermodynamic functions from concepts of statistical mechanics; chemical equilibrium, availability, and computation of vapor liquid equilibrium compositions.

 

CHBE 136 - Air Pollution (Cross-listed as Civil & Environmental Engineering 136)

See Civil & Environmental Engineering four course description.
 

CHBE 138 Hazardous Waste Treatment Technologies (Cross-Listed as Civil & Environmental Engineering 136)

See Civil & Environmental Engineering for course description.
 

CHBE 140A - Surface and Colloid Chemistry
Prerequisite: consent

Emphasis on fundamental concepts: attractive and repulsive forces between particles in a dispersion; stabilization and flocculation of a dispersion; electrokinetic phenomena; surfactants; contact angle and wetting; phenomena at curved interfaces; capillarity; rheology of suspensions; drying of coating; emulsions. For students in chemical engineering and in other disciplines in which surface chemistry plays an important role.

 

CHBE 150 - Crystallization
Prerequisite: Consent

Theory of crystal growth and nucleation, and processes for production of crystals. Emphasis on industrial crystallizations from solutions and the use of crystallization as a separation process. Special topics include effects of additives, growth of crystals from melt or vapor; purification by recrystallization; zone refining.

 

CHBE 155 - Chemical Processing Industries: Management, Structure, and Dynamics
Prerequisite: consent.

Identifies important products, suppliers, and customers of the chemical industry (CPI), and their quantitative interaction within the United States economy. Role of intellectual property in the CPI. Topics include economics of CPI raw materials and products, financial measure of performance, input/output method for CPI transactions, and current technical and business developments in the industry. For students interested in the chemical industry and how its technology is mobilized to benefit society. Accredited for minor in engineering management.

 

CHBE 160 - Biochemical Engineering
Prerequisite: Chemical Engineering 102

Thermodynamics of biological reactions, principles of fermentation processes, and chemical engineering applications to bioreactor analysis are studied.

 

CHBE 161 - Protein Purification
Prerequisite: Chemical Engineering 23

Modern techniques for the separation and purification of small and large biomolecules are covered. Topics include techniques especially designed for today's biotechnology products, such as electrophoresis, hydrophobic interaction/reverse phase, gel filtration, and other forms of chromatography. Process economics, GMP operation, and case studies of biotechnology industry separations.

 

CHBE 162 - Introduction to Biotechnology (Cross-Listed as Biology 162)
Prerequisite: consent.

Overview of key aspects of molecular biology and engineering aspects of biotechnology. Lecture topics include molecular biology, recombinant DNA techniques, immunology, cell biology, protein purification, fermentation, cell culture, combinatorial methods, and bioinformatics. Includes a semes5er-long technical project and oral presentation. (Group A).

 

CHBE 163 - Recombinant DNA Techniques
Prerequisite: Consent

This course is designed to the familiarize the student with methods used to produce recombinant DNA products. The course will include lecture and laboratory. The lectures will cover fundamental aspects of recombinant DNA methodologies that will be used in the laboratory, as well as some of applications for the techniques. The laboratory will provide hands-on experience with the key skills used in genetic engineering, including DNA isolation, restriction enzyme mapping, cloning and selection, protein expression, gel electrophoresis, polymerase chain reaction, DNA sequencing, and related techniques.

 

CHBE 164 - Biomaterials and Tissue Engineering
Prerequisites: Minimum of junior standing and an introductory course in biology, chemistry or engineering, or consent.

Synthesis, characterization and functional properties of organic and inorganic biomaterials and the process of tissue engineering are covered. Fundamental issues related to the utility of biomaterials will be explored based on their biocompatibility, stability, interfaces and fate in the body. Clinical applications for biomaterials will be explored as will new directions in design and synthesis to achieve better biocompatibility. Tissue engineering and biomedical implants will be emphasized as key uses for biomaterials. Testing methods, regulatory issues, legal constraints, and emerging research directions will also be discussed. Students will prepare a project report on a key aspect of the field of biomaterials and tissue engineering.

 

CHBE 165 - Advanced Fluid Mechanics (Cross-listed with ME 165)
Prerequisite: Engineering Science 8

Euler's, Bernouli's, Navier-Stokes and energy equations; potential, viscous and boundary-layer flows; separation flows; applications to various physical systems.

 

CHBE 166 - Principles of Cell and Microbe Cultivation
Prerequisites: Biology 13, 52, Chemical Engineering 22 or Consent

In-depth examination of microbial and mammalian cell cultivation and concombinant production of commercially important products. Mechanism and methods of measurements and quantitative analysis of growth, product formation and nutrient utilization kinetics in characterizing and optimizing for cell mass or product formation. Discussion of fundamental parameters controlling bioreactor design and scale-up. Systems studied include production of proteins in recombinant organisms, antibiotics, amino acids and the cultivation of mammalian cells.

 

CHBE 167 - Metabolic and Cell Engineering

The goal of this course is to present a framework for quantitative analysis of cell functions as integrated molecular systems, and introduce students to an emerging discipline whose objective is to rationalize selection of enzyme or pathway targets for engineering biotechnologically or biomedically useful cells. To this end, course material analyzes cell-level processes in terms of underlying biochemical reaction mechanisms applying kinetics, thermodynamics, and transport, emphasizing an engineering, problem-oriented perspective. Cellular processes to be discussed include metabolism and energy production, protein synthesis and secretion, regulation of gene expression, and transduction of signals from extracellular environment. Topics include: metabolic biochemistry, molecular regulation of pathway activity, stoichiometry of cellular reactions, material balances, statistical hypothesis testing and other tests of data consistency, topological analysis of metabolic reaction networks, metabolic flux analysis, metabolic control analysis, and pathway synthesis and optimization. Throughout the course, cases studies (papers) will be discussed to illustrate the application of course concepts in industry and current research.

 

CHBE 168 - Biotechnology Processing Projects Laboratory
Prerequisites: Chemical Engineering 24 or Consent

Hands-on experience with techniques encountered in biotechnology processing. Each lab is accompanied by a lecture and relevant readings which present the underlying principles. Each student performs experiments including important analytical procedures, microbial cell cultivation, separation and purification of proteins and small biochemicals, and in biocatalysis. Projects promote quantitative and interpretive skills as well as teamwork in a multidisciplinary environment.

 

CHBE 169 - Topics In Biotechnology (Cross-Listed as Biology 169)

Seminar course. Journal articles on current biotechnology-related research are reviewed and presented. Leading researchers in the field present seminars and students assess future research directions based on in-depth review of articles and presentations (Group A).

 

CHBE 170 - Technological Processes and the Environment
Prerequisites: Junior standing or consent

Survey of environmental problems arising from commonplace technologies, e.g., transportation, power generation, microelectronics processing, chemicals manufacturing. The course considers the introduction of chemicals into the environment and illustrates how to predict the fates of those chemicals in air-water-land-biota systems. Environmental and health consequences of products and the processes used for their manufacture are examined. Life Cycle Analysis methodologies are implemented in case studies. Development of technologies and policies for pollution prevention and a sustainable environment are discussed.

 

CHBE 173 - Clean Energy Technologies and Policy Issues (Cross-listed with Fletcher School)

This course considers current issues in power generation, identifying the technologies used to meet the Clean Air Act regulations by the electric utilities and the automobile manufacturers. Topics include the electric utility deregulation, distributed power sources, new energy markets, fuel efficiency, and global effects of fossil fuel use. Alternative fuels and engines will be examined from the point of view of technology readiness and global market penetration to curb air pollution and decrease carbon emissions. The costs of energy technologies and the global impacts of present policies in the U. S. and abroad will be evaluated.

 

CHBE 175 - Biomedical Engineering II (Cross-listed as ES 175)
Prerequisites: Consent

See Chemical Engineering 75 for course description. Includes semester-long technical project and oral presentation.
 

CHBE 185 - Drug Product Formulations

Drug Product Formulation, describing the evolution of a biopharmaceutical from bulk purified protein to delivery as a single patient dosage. Course includes the selection of protein formulation, evaluation of stability, fill and finish, and process validation. Fundamental concepts in protein chemistry, kinetics, and mass transport are included in describing the route a drug takes from bulk protein to stable single dosage. Also covered are mathematical concepts of experimental design and statistics for process validation.

CHBE 193/194: Special Topic - Clean Energy Technologies & Policy Issues
Prerequisite: Consent

Guided individual study of an approved topic to develop the art of self-teaching. Appraisal of the student's knowledge in the approved area will be based on a written and/or oral examination. Arrangements with a department member are required by the student prior to registration in the course. For master's degree candidates.

 

ChBE 193M – Management of Technology in the Chemical and Biotechnology Industries

The course will provide undergraduate and graduate students with an orientation to technology management and product development with emphasis on several industries including the chemical, pharmaceutical and biotechnology sectors. Students will learn basics about business and technology strategy, how new products are developed and commercialized and how technological innovation is nurtured and managed. Students will also be introduced to financial concepts that are necessary for better understanding of technology management. This course is designed for students who want to get an "inside view" of the types of problems and opportunities that confront leaders in several different industries.

Prerequisites: There are no technical prerequisites for this class. However, students must be willing to participate in class discussions. This approach is designed to develop communication skills, which are vital for increasing effectiveness in industry and other business environments.
 

CHBE 213 - Radiative Transfer (Cross-listed as Mechanical Engineering 213)
Prerequisites: Consent

Physics of radiation treated from microscopic and macroscopic viewpoints, surface characteristics, analysis of radiant heat transfer, luminous and nonluminous gaseous radiation, solar radiation, applications.

 

CHBE 291 and 292- Graduate Seminar

Presentation of individual reports on baisc toipics to a semnar group for discussion and criticism.

 

CHBE 293 and 294 - Special Topics
Prerequisite: consent

Guided individual study of an approved topic. Designed to develop the art of self-teaching. Appraisal of the student's knowledge in the approved area will be based on a written and/or oral examination. Arrangements with a department member are required by the student prior to registration in the course. For doctoral degree candidates.

 

CHBE 295 and 296 - Thesis

Guided research on a topic suitable for a master's thesis. Credit as arranged.

 

CHBE 297 and 298 - Thesis

Guided research on a topic suitable for a doctoral dissertation. Credit as arranged.

 

CHBE 299 Master of Engineering Project

Execution of a major project equivalent to one course credit under the guidance of faculty adviser. Each project must address a substantive engineering analysis or design problem. Students are required to submit a written report and make an oral presentation of their project work. Students are expected to enroll in this course the last term of their degree program. Enrollment is limited to and required for matriculated students in the master of engineering program.