Professor Christos Georgakis, Chair; Modeling, optimization
and process control, batch processing
Professor Linda Abriola, Groundwater hydrology, contaminant fate and
transport
Professor Maria Flytzani-Stephanopoulos, Environmental catalysis, clean energy technologies, nanostructured oxides
Professor David L. Kaplan, Biotechnology, biomaterials,
tissue engineering
Professor Nak-Ho Sung, Polymers and composites, interface science, polymer
diffusion, surface modification
Professor Kenneth A. Van Wormer, Jr., Optimization, nucleation, reaction
kinetics, VLSI fabrication
Associate Professor Jerry H. Meldon, Mass transfer, membrane processes,
reaction-separation coupling
Associate Professor Daniel F. Ryder, Polymer
and ceramic materials processing,
inorganic/organic nanocomposite materials
Assistant Professor Kyongbum Lee, Metabolic
engineering, tissue engineering, systems biology
Assistant Professor Blaine Pfeifer, Biotechnology,
cellular engineering, natural product biosynthesis and development
Research Professor Howard Saltsburg,
Catalysis, materials science
Research Associate Professor Aurelie Edwards, Physiological modeling
Research Associate Professor Vladimir Volloch, Cellular and molecular
biology
Adjunct Professor Walter Juda, Electrochemistry and chemical reaction
engineering
Adjunct Professor Gordana Vunjak-Novakovic, Transport phenomena, tissue
engineering, bioreactors
Adjunct Assistant Professor Brian Kelley, Novel methods for protein
purification, large-scale purifications, high-density bacterial fermentation
Chemical engineering is concerned with making chemistry, and more recently biology, serve society. Chemical engineers tend to be engineering generalists knowledgeable in the applications of chemistry. They are well-trained in science and mathematics and appreciate economics. Their professional skills are required wherever engineering and chemistry or biology intersect. This occurs not only in the chemical industry but also in the biological, environmental, health, legal, and medical fields. Chemical engineers are researchers, designers, producers, and managers. Petroleum, paints, plastics, paper, detergents, pharmaceuticals, vaccines, microchips, drugs, processed foods, fertilizers, conventional and nuclear fuels, insecticides, rocket propellants, synthetic fibers, and rubber are among the many products they help create.
The student who majors in chemical engineering has considerable flexibility in choosing a program and is assisted in doing so by a departmental adviser. A student may choose a curriculum leading to the professional degree of bachelor of science in chemical engineering or a curriculum leading to the more general bachelor of science in engineering. The professional degree curriculum is accredited by the Accreditation Board for Engineering and Technology (ABET) and prepares its recipients for professional practice or graduate study. Recipients of this degree usually follow engineering careers. The degree is not restrictive, however, and many students use the professional degree curriculum as preparation for further study in medicine, law, business, or science.
The general engineering degree curriculum is similar to that of a science major in the College of Liberal Arts. It allows more electives than the professional degree curriculum, as well as more courses in the humanities and social sciences. The curriculum is for students who want an understanding of engineering fundamentals, but who will make their careers in related fields such as medicine, business, and law. The degree has not been submitted to ABET for accreditation.
Undergraduates are encouraged to participate in the department's research programs and
independent study for degree credit.
Undergraduate Program
Bachelor of Science in Chemical Engineering
The mission of the BSChE degree program offered by the Chemical and
Biological Engineering Department is to provide its undergraduate students:
a) A strong foundation in the pure sciences including biology, chemistry,
mathematics and physics.
b) A solid understanding of the fundamental chemical engineering sciences,
coupled with quantitative skills, so as to provide a basis for a successful
professional career within the technology fields.
c) Training of communication skills consistent with the requirements of both the
technical professions and the broader community in which they live.
d) A capacity and desire for the pursuit of life-long learning.
The faculty is committed to accomplishing this mission through the integration
of teaching and research.
The goals of the BSChE program are to:
a) Provide students a sound technical foundation in both the traditional and
emerging areas of chemical engineering. In particular, the Tufts BSChE program
emphasizes the incorporation of the biological sciences into the technical
foundation throughout the curricula.
b) Provide quality instruction emphasizing the logical identification and
solution of problems; the solution of complex quantitative problems using
computational methods; and the application of engineering analysis to the
chemical and biological sciences.
c) Offer a high-quality instruction that encompasses not only the technical
content but also makes students aware of the societal implications of
technology.
d) Provide students the opportunity to formulate, analyze, and solve engineering
problems within a team structure; and to communicate their findings in both
written and oral forms.
e) Encourage and provide opportunities to sample specialized areas through
elective courses, minor programs, industrial internships, and independent
research; and as such, to foster an appreciation for life-long education.
A suggested program of required courses and free electives for the bachelor of science
degree in chemical engineering (accredited program) follows.
First-Year Program
The program is similar for all engineering students with the additional
requirement that two courses in introductory chemistry and also Physics 11 be completed.
FALL TERM
Engineering 1 (Introduction to Computers in Engineering)
Engineering - Introductory elective
Mathematics 11 (Calculus 1)
Chemistry 1 or 11 with laboratory (Chemical Foundations)
English 1 (Expository Writing)
SPRING TERM
Engineering 2 (Engineering Graphics)
Engineering - Introductory elective
Mathematics 12 (Calculus II)
Chemistry 2 or 12 with laboratory (Chemical Principles)
Physics 11 with laboratory (General Physics I)
Humanities or social sciences elective
Sophomore Year
FALL TERM
Chemistry 31 and 33 (Physical Chemistry with laboratory)
Mathematics 13 (Calculus III)
Engineering Science 10 (Structure and Strength of Materials)
Chemical and Biological Engineering 10 with laboratory (Thermodynamics and Process Calculations I)
Engineering Science 11 (Introduction to Biology)
SPRING TERM
Chemical and Biological Engineering 11 (Thermodynamics and Process Calculations II)
Mathematics 38 (Differential Equations)
Advanced Science or CHBE elective
Humanities or social sciences elective
Junior Year
FALL TERM
Chemical and Biological Engineering 20 (Unit Operations and Transport Phenomena
I)
Chemical and Biological Engineering 21 (Unit Operations and Transport Phenomena
II)
Chemical and Biological Engineering 39 (Applied Mathematics and Software for Chemical
Engineers)
Chemistry 51 and 53 (Organic Chemistry with laboratory)
Engineering Science 3 (Introduction to Electrical Engineering)
Humanities or social sciences elective
SPRING TERM
Biology 152 (Biochemistry and Cellular Metabolism)
Chemical and Biological Engineering 22 (Unit Operations and Transport Phenomena III)
Chemical and Biological Engineering 102 (Reactor Design)
Advanced chemistry elective
Chemical and biological engineering elective
Senior Year
FALL TERM
Chemical and Biological Engineering 23 (Unit Operations and Transport Phenomena IV)
Chemical and Biological Engineering 24A (Chemical Engineering Projects Laboratory)
Chemical and Biological Engineering 109 (Process Dynamics and Control)
Chemical and biological engineering elective or undergraduate research
Advanced humanities or social sciences elective
SPRING TERM
Chemical and Biological Engineering 24B (Chemical Engineering Projects Laboratory)
Chemical and Biological Engineering 60 (Chemical Process Design)
Chemical and biological engineering elective
Advanced chemistry elective
Free elective
Approved Advanced Chemistry Elective Courses
Two advanced chemistry electives are required and are to be chosen from the following
list (exceptions must be approved by the department).
Biology 153 Topics in Biochemistry
Chemical and Biological Engineering 121 Principles of Polymerization
Chemical and Biological Engineering 122 Physical Chemistry of Polymers
Chemical and Biological Engineering 140 Surface and Colloid Chemistry
Chemistry 32 Physical Chemistry II
Chemistry 42 Analytical Chemistry
Chemistry 52 Organic Chemistry
Chemistry 55 Advanced Synthesis Laboratory
Chemistry 61 Inorganic Chemistry
Chemistry 132 Chemical Kinetics
Chemistry 133 Quantum Mechanics
Chemistry 135 Biophysical Chemistry
Chemistry 136 Spectroscopy and Molecular Structure
Chemistry 141 Instrumental Analysis
Chemistry 150 Intermediate Organic Chemistry
Chemistry 151 Physical Organic Chemistry
Chemistry 152 Advanced Organic Synthesis
Chemistry 161 Advanced Inorganic Chemistry
Chemistry 162 Chemistry of Transition Metals
Chemistry 163 Diffraction Methods of Structure Determination
One advanced chemistry elective may be substituted by an advanced natural
science elective from the following list.
Biology 41 General Genetics
Biology 46 Cell Biology
Biology 104 Immunology
Biology 105 Molecular Biology
Biology 106 Microbiology
Biology 134 Neurobiology
Physics beyond Physics 12
Combined Bachelor's and Master's Degrees
Program
This program is conducted jointly by the Department of
Chemical and Biological Engineering and the Graduate School of Arts and
Sciences. Exceptional students may combine undergraduate and graduate courses
and are simultaneously enrolled
in bachelor's and master's degree programs. Both degrees are
awarded only on completion of the entire program;
a student may not receive one degree earlier, even if the requirements for that
degree have been met. Combined-degrees students must pay four years of
undergraduate tuition and the entire tuition for the master's degree.
The combined-degrees program is one way of recognizing the fact that an increasing number of undergraduates are entering college with exceptional preparation in certain areas and that many are capable of doing graduate work in their upper-class years.
Students seeking admission to the program should consult their undergraduate advisor and their prospective graduate advisers before applying to the graduate school. Combined-degrees students are expected to fulfill all the requirements of the undergraduate and graduate programs. No courses offered in fulfillment of one set of requirements may be used for the other.
Admission to the program is normally during the junior year.
Only in exceptional cases will an application be accepted after the junior year.
Therefore, students interested in the program should contact their advisers
early in their academic career to facilitate program planning. A student may
elect to withdraw from the program at any time by filing the appropriate
petition.
Bachelor of Science in Engineering
This general engineering degree program combines liberal arts with basic
engineering education in a four-year nonaccredited program. It is for the individual who
may not wish to function as a professional engineer, but who wants a basic science and
technology background as preparation for a career in a related field such as medicine,
law, or business.
Flexibility is built into the program so that students can pursue their own interests to a greater extent than is possible in the accredited engineering programs. The thirty-eight courses required for the completion of the program fall into the four categories listed below.
Foundation requirements - ten course credits: Mathematics 11, 12, 13, and 38; Physics 1
or 11; Chemistry 1, 2, 31, 33, 51 (or 50), and 53.
Engineering science - eleven courses: four courses in engineering science and seven
electives in science, mathematics, or engineering.
Chemical and biological engineering - six courses, including Chemical Engineering
10 and 11.
Free electives - eleven courses, including at least six in the humanities and
social sciences.
Premedical, Predental, and Preveterinary Preparation via the Chemical Engineering
Curriculum
Students interested in entering medical, dental, or veterinary school after
graduation can satisfy professional school entrance requirements while working toward a
bachelor's degree in the Department of Chemical and Biological Engineering.
Modern medical practice and research is increasingly dependent on engineering methods and devices. Automatic instruments now monitor and assist body function. New synthetic materials repair and even replace body tissue. Mathematical equations that describe the flow of fluids in pipes apply to the flow of blood in veins. The kidney, lung, and heart functions have analogies in chemical engineering process equipment.
Computers are used in diagnosis and research. Given these important areas in medicine, there is a need for students to combine undergraduate engineering with graduate medical training.
Two kinds of preparatory programs are suggested by the department. The first is the professional degree program in chemical engineering; a student choosing this program must complete all the requirements for the accredited bachelor of science degree in chemical engineering. Courses required for entrance into medical, dental, or veterinary school are met through selection of electives, summer school, or an increase in course load.
The second program has greater flexibility and leads to the nonaccredited bachelor of science
degree in engineering, described above. This program gives students a foundation in engineering
fundamentals and the possibility of satisfying professional school entrance
requirements and pursuing individual interests in other fields through selection
of electives.
Undergraduate Minor Programs
In addition to completing the courses for the concentration
requirement, an undergraduate may elect to enroll in a minor program in a
different, although possibly related field. All courses used in fulfillment of
the minor program must be taken for a grade. No more than two courses used to
fulfill a foundation or concentration requirement may be counted toward
fulfillment of the minor. Students may not complete both a minor and a
concentration in the same discipline.
Biotechnology Engineering Minor
Five courses are required to obtain this minor. Biology 152 or Chemistry
156; two courses from the following: Chemical and Biological Engineering 62,
161, or 166; one course from the following: Biology 50, Chemical and Biological
Engineering 163 or 168; and an elective chosen from an approved list. No more
than two courses used to fulfill a foundation, distribution, or concentration
required may be counted toward the minor.
Chemical Engineering Minor
Five courses are required: Chemical and Biological Engineering 10, 11,
39, 102; and a chemical engineering elective approved by the minor committee.
All courses must be taken for a grade. No more than two courses used to fulfill
a foundation, distribution, or concentration requirement may be counted toward
the minor.
Second Major in Biotechnology
This program is offered as a major only in conjunction with enrollment in a regular
undergraduate major, ordinarily excluding interdisciplinary programs. The biotechnology
program has been designed with two tracks: a science track for undergraduate students
enrolled in the College of Liberal Arts, and an engineering track for undergraduate
students enrolled in the School of Engineering.
Core Curriculum
Biology 1/Engineering Science 11 Introduction to Biology
or Biology 13 Cells and Organisms
Biology 41 Genetics
Chemical and Biological Engineering/Biology 62 Introduction to Biotechnology
One laboratory course from:
Biology 50 Experiments in Biology II
Chemical and Biological Engineering 163 Recombinant DNA Techniques
Chemical and Biological Engineering 168 Biotechnology Processing Projects
Laboratory
Track curricula
SCIENCE TRACK
Two core courses:
Biology 105 Molecular Biology
Biology 152 Biochemistry and Cellular Metabolism
or Chemistry 156 Biochemistry
Four electives from an approved list provided by the department. Up to two credits of research may be counted toward electives.
ENGINEERING TRACK
Two core courses:
Chemical and Biological Engineering 161 Biochemical Separations
Chemical and Biological Engineering 166 Principles of Cell and Microbe Cultivation
Four electives from an approved list provided by the department. One credit of research may be counted toward electives.
Graduate Program
The Department of Chemical and Biological Engineering offers instruction leading to the
degrees of master of science, master of engineering, and doctor of philosophy. General GRE test scores are
required of applicants to all graduate degree programs.
Master of Science or Master of Engineering with Major in Chemical Engineering
Candidates for the master's degree programs in chemical engineering usually
hold a bachelor of science degree in chemical engineering or in chemistry, with a suitable
background in engineering subjects. A strong background in mathematics, biology,
chemistry, and physics is essential. Students with degrees in physical science or other
engineering disciplines may become candidates upon satisfactory completion of certain
upper-level undergraduate courses. A highly recommended alternative to formal enrollment
in academic-year, undergraduate chemical engineering courses is the intensive two-course
summer sequence of Chemical and Biological Engineering 1 and 2. Successful completion of these courses
qualifies a student to apply to the master's degree programs.
Students enrolled in the master of science degree program must take seven courses for letter grades. No more than one of these seven may be guided individual study. Generally, at least five credits are from a list of chemical engineering courses; the remaining courses may be in allied fields. A thesis (three credits) is also required along with an oral examination covering the field of the student's thesis. Only students in the master of science degree program may apply for financial assistance.
Students enrolled in the master of engineering degree program must take ten courses for letter grades. Generally, at least eight credits are from a list of chemical engineering courses; the remaining courses may be in allied fields.
Master of Science or Master of Engineering with Major in Biotechnology Engineering
Candidates for the master's degree programs in biotechnology
engineering usually hold a bachelor of science degree in
chemical engineering with a suitable background in biological sciences. A strong
background in mathematics, chemistry, and physics is essential. Students with degrees in
physical science or other engineering disciplines who have no background in biology may
become candidates upon satisfactory completion of certain undergraduate courses. For
students without undergraduate chemical engineering degrees, a highly recommended
alternative to formal enrollment in academic-year, undergraduate chemical engineering
courses is the intensive two-course summer sequence of Chemical and Biological Engineering 1 and 2.
Successful completion of these courses qualifies a student to apply for the master's
program.
Students enrolled in the master of science degree program must take seven courses for letter grades. No more than one of these seven may be guided individual study. Generally, at least four credits are from a list of chemical engineering courses and three are graduate biology/chemistry courses selected from a list. A thesis (three credits) is also required for the degree. Only students in the master of science degree program may apply for financial assistance.
Students enrolled in the master of engineering degree program must take ten courses for letter grades.
Generally, at least six credits are from a list of chemical engineering courses
and
four are graduate biology/chemistry courses selected from a list. No more than one of the ten
courses may be guided individual study.
Doctor of Philosophy
Doctoral degrees are offered in chemical engineering and in biotechnology engineering.
Candidates for the doctor of philosophy degree, except when otherwise recommended by
the department, will have completed the seven courses required for the master of
science degree. A
qualifying examination (in areas selected by a committee and the department) must be
satisfactorily completed. This examination is usually taken after one full year of
residence.
In addition to satisfying the university requirements for the doctor of philosophy
degree, a candidate must satisfactorily complete a program of courses (established by
the candidate's committee) and write a doctoral dissertation. The doctoral dissertation is considered the candidate's major task. It must represent a
significant contribution to the field and contain material worthy of publication in a
recognized professional journal.
Undergraduate Courses
10, 11 Thermodynamics and Process Calculations I, II. Applications of conservation of mass and energy to industrial chemical processes, with emphasis on engineering units/dimensions and stoichiometric relationships. Thermodynamic concepts--first and second laws, heat, work, energy, entropy, equilibrium, reversibility, equations of state--are introduced in process contexts. Emphasis in Part II on multiphase, multicomponent, and reactive systems. Use of personal computer software required. Prerequisite for Chemical and Biological Engineering 11: Chemistry 31. Members of the department
20 Equilibrium Staged Separations. Design of separation processes that can be analyzed using equilibrium behavior of systems. Techniques for the analysis of processes including distillation, adsorption, and extraction will be developed. Prerequisites: Chemical and Biological Engineering 10, 11; Mathematics 13; ability to utilize computer-based numerical methods. Van Wormer
21 Fluid Mechanics. Fundamentals of fluid mechanics and their applications to the design and understanding of flow processes. Transport phenomena is also incorporated with emphasis on the heat, mass, momentum transport analogy. Problem solving is a major component of the course. Prerequisites: Chemical and Biological Engineering 10, 11; Mathematics 13. Van Wormer
22 Heat and Mass Transfer. Principles of heat and mass transfer. Steady-state conduction and diffusion processes. Convective transport of heat and mass in laminar and turbulent flows in conduits and over various surfaces. Applications to design of heat exchangers. Natural convection. Combined heat and mass transfer applications. Prerequisites: Chemical and Biological Engineering 10, 11; Mathematics 13. Van Wormer, Ryder
23 Rate Controlled Separations. Separation processes which require a rate analysis for complete understanding in contrast to equilibrium-base analyses. Problem solving is a major component of the course. Prerequisites: Chemical and Biological Engineering 20, 21, 22; Mathematics 13; appropriate computer-based mathematical tools. Van Wormer
24A, 24B Chemical Engineering Laboratory. Laboratory projects in the area of applied chemical and biological engineering processing. Students work in groups and choose one project for the whole term. Hands-on experience with practical problems of industrial concern. Training in planning and executing research projects, integration in problem solving, oral presentations, and written reports are integral parts of this laboratory course. Fall and spring. Members of the department
39 Applied Mathematics and Software for Chemical Engineers. This course reviews/covers analytical techniques including Laplace transformation and the use of Bessel and other special functions; and numerical methods of analysis and their implementation using commercially available software. All are applied in the last two years of the undergraduate chemical engineering curriculum. Ryder
60 Chemical Process Design. The principles of design and economic evaluation of
chemical processes are illustrated through the preliminary design of a commercial project.
Working in groups on assigned or selected portions of the overall project, students are
required to make integrated use of a wide variety of fundamentals and principles gained
from previous courses. Work laboratories are supplemented by appropriate lectures.
Opportunity for independent study. Use of design software. Prerequisites: Chemical
and Biological Engineering 11 and 23. Members of the department
62 Molecular Biotechnology. (Cross-listed as Biology 62.) Overview of key aspects of molecular biology and
engineering aspects of biotechnology. Lecture topics include molecular biology,
recombinant DNA techniques, immunology, cell biology, protein purification, fermentation,
cell culture, combinatorial methods, and bioinformatics. (May be taken at 100
level with consent; see below.) Prerequisite: consent. Spring. Kaplan
75 Biomedical Engineering II. (Cross-listed as Engineering Science 75.) The course consists of two main parts: fundamental engineering methodologies and clinical applications. The course is the complement to Biomedical Engineering I. Topics covered: biomaterials, tissue engineering, drug discovery, genomics/proteomics, and related issues. Fundamental concepts in biochemistry, molecular biology, chemical engineering, polymer science, and biophysics are studied. Applications for these techniques are addressed with respect to medical problems. (May be taken at 100 level with consent; see below.) Prerequisite: consent. Kaplan
93, 94 Independent Study. Guided individual study of an approved topic. Designed to develop self-teaching skills of the advanced undergraduate. Appraisal of the student's knowledge in the chosen topic based on written and/or oral examination. Prerequisite: consent of the department. Course credit as arranged. Members of the department
95, 96 Research. Preparation of a report based on personal research, design, or experiment. Prerequisite: consent of the department. One course credit. Members of the department
99 Internship in Chemical Engineering. A mentored professional experience in chemical engineering at an off-site organization. The internship must conform to all the requirements of the School of Engineering Internship Program. The department will grant course credit for internships if all of the following conditions are met: 1) The project is approved in advance by the department, 2) a faculty mentor has supervisory and technical control of any work that receives credit, and 3) a written report is submitted that is evaluated by the faculty adviser and the outside institutional supervisor. Prerequisite: junior or senior standing. Members of the department
Courses for Undergraduate and Graduate Students
101 Mathematical Methods in Chemical Engineering. Application of numerical methods and digital computers to the solution of mathematical problems in chemical engineering. Subjects include interpolation and approximation, roots of algebraic equations, numerical integration, and solution to ordinary and partial differential equations. For juniors, seniors, and graduate students. Van Wormer
102 Chemical Reactor Design. Treatment of chemical reaction equilibrium and kinetic fundamentals and application of them to the design of reactors. Topics include interpretation of reaction-rate data, establishment of reaction mechanism and rate-controlling steps, sizing, and optimization of reactors. Use of personal computer software is encouraged. Lee
103 Chemical and Catalytic Reaction Engineering Topics. Applied chemical kinetics, reaction rate theories, complex kinetics, chain reactions, reactor stability and sensitivity to operating parameters. Mass and energy transfer limitations in heterogeneous noncatalytic and catalytic reactor design. Prerequisite: Chemical and Biological Engineering 102. Flytzani-Stephanopoulos
104 Separation Processes. Material on mass-transfer separation processes beyond that covered by the undergraduate unit operations course. Computational techniques employing digital computers are emphasized. Prerequisite: Chemical and Biological Engineering 23. Ryder, Meldon
107 Membrane Separation Processes. Fundamentals of liquid/solid, liquid mixture, and gas mixture separations using synthetic membranes. Processes include microfiltration, ultrafiltration, reverse osmosis, electrodialysis, and gas permeation, with applications to industrial process streams, bioprocessing, water purification, and hazardous waste control; also novel membrane reactors and membrane extraction. Emphasis on application of mass transfer and fluid flow principles; also process configuration selection, to design and scale-up. Prerequisite: Chemical and Biological Engineering 23. Meldon
109 Process Dynamics and Control. Mathematical modeling of chemical processes with ordinary differential equations. Feedback, feedforward, and environmental control. Block diagrams. Laplace transformation. Linearization techniques. Frequency response. Laboratory exposure to instrumentation. Prerequisites: Chemical and Biological Engineering 21 and 22, or consent. Ryder
110 Optimization. Introduction to fundamentals of optimization and operations research. Need for identifying the objective function to be maximized or minimized, along with the imposed constraints, is stressed. Familiarity and skill with several optimization techniques, with emphasis on linear and dynamic programming, are developed. Van Wormer
112 Advanced Heat Transfer. (Cross-listed as Mechanical Engineering 112.) General treatment of heat transfer in solids and fluids. Topics include transient and steady-state conductions, turbulent diffusion, boiling, condensation, numerical methods, and computer-aided solutions. Prerequisite: Mechanical Engineering 16. Abedian, Manno
114 Advanced Transport Phenomena. Heat, mass, and momentum transfer beyond Chemical Engineering 23. Emphasis on coupling among transport processes and with chemical reaction. Problems of industrial and biological interest. Prerequisite: Chemical and Biological Engineering 23. Edwards, Meldon
121 Principles of Polymerization. Synthesis of polymeric materials. Three major types of polymerization--step, chain, and ring-opening--are reviewed with emphasis on reaction mechanisms, kinetics, and thermodynamics of the reactions, and their relationships to molecular weight and molecular structures of macromolecules. Prerequisites: physical and organic chemistry. Sung
122 Physical Chemistry of Polymers. Physicochemical properties of polymeric materials with emphasis on the relationship between molecular architecture and physical properties. Topics include polymer solution theories, thermal transitions, conformational analysis, polymer microstructure, crystallinity and morphology, the rubbery and glassy states, rheology, and statistical thermodynamics. Prerequisite: Chemistry 31. Sung
135 Advanced Thermodynamics. Thermodynamics as applied to chemical engineering. Attention is given to the derivation of thermodynamic functions from concepts of statistical mechanics; chemical equilibrium, availability, and computation of vapor-liquid equilibrium compositions. Prerequisite: Chemical and Biological Engineering 11 or equivalent. Meldon
136 Air Pollution. (Cross-listed as Civil and Environmental Engineering 136.) A study of health and environmental effects from air pollution, dispersion modeling, air pollution laws and regulations, fate and transport of air pollution, and design of pollution control equipment and processes. Prerequisites: differential equations, physics, chemistry, fluid/thermal sciences; or advanced undergraduate standing. Fall. Zemba
138 Hazardous Waste Treatment Technologies. (Cross-listed as Civil and Environmental Engineering 138.) Hazardous waste treatment options based on physical, chemical, biological, and thermal processing technologies. Brief review of definitions and appropriate hazardous waste legislation. Introduction to pollution prevention. Traditional end-of-pipe treatment technologies. Applications to include solvent recovery, chemical fixation, land disposal, biodegradation, and special wastes. Incineration and associated environmental discharges constitute a major portion of course. Emerging technologies and evaluation of technical/economic process viability. Prerequisite: senior standing or consent. Cohen
140 Surface and Colloid Chemistry. Emphasis on fundamental concepts: attractive and repulsive forces between particles in a dispersion; stabilization and flocculation of a dispersion, electrokinetic phenomena; surfactants; contact angle and wetting; phenomena at curved interfaces; capillarity; rheology of suspensions; drying of coatings; emulsions. For students in chemical engineering and other disciplines in which surface chemistry plays an important role. Prerequisite: consent. Members of the department
150 Crystallization. Theory of crystal growth and nucleation, and processes for production of crystals. Emphasis on industrial crystallizations from solutions and the use of crystallization as a separation process. Special topics include effects of additives, growth of crystals from melt or vapor, purification by recrystallization, and zone refining. Prerequisite: consent. Members of the department
160 Biochemical Engineering. Thermodynamics of biological reactions, principles of fermentation processes, and chemical engineering applications to bioreactor analysis are studied. Prerequisite: Chemical and Biological Engineering 102. Flytzani-Stephanopoulos
161 Protein Purification. (Formerly Biochemical Separations.) Methods of purifying proteins at a large scale for therapeutic or industrial uses. Focus on unit operations found in a typical process flowsheet including centrifugation, membrane filtration, most modes of chromatography, and lyophilization. Topics include introduction to protein chemistry and analytical methods, effects of production host choice, and protein stability. Process economics, GMP operations and validation, and case studies of biotechnology industry separations. Prerequisite: consent. Kelley
162 Molecular Biotechnology. (Cross-listed as Biology 162 and Biomedical Engineering 162.) See Chemical Engineering 62 for course description. Includes a semester-long technical project and oral presentation. Prerequisite: consent. Kaplan
163 Recombinant DNA Techniques. (Cross-listed as Biology 163 and Biomedical Engineering 163.) This lecture and laboratory course is designed to familiarize students with methods used to produce recombinant products. The lectures cover fundamental aspects of recombinant DNA methodologies used in the laboratory as well as some of the commercial applications of these techniques. The laboratory provides hands-on experience with the key skills used in genetic engineering, including DNA isolation, restriction enzyme mapping, cloning and selection, protein expression, gel electrophoresis, polymerase chain reaction, DNA sequencing, and related techniques. Cannot be taken for credit if Biology 50 is taken for credit. Summer. Prerequisite: consent. Kaplan
164 Biomaterials and Tissue Engineering. (Cross-listed as Biomedical Engineering 164 and Biology 174.) Synthesis, characterization, and functional properties of organic and inorganic biomaterials, and the process of tissue engineering are covered. Fundamental issues related to the utility of biomaterials are explored based on their biocompatibility, stability, interfaces, and fate in the body. Clinical applications for biomaterials are investigated, as are new directions in design and synthesis to achieve better biocompatibility. Testing methods, regulatory issues, legal constraints, and emerging research directions are also discussed. Prerequisite: consent. Kaplan, Vunjak
165 Advanced Fluid Mechanics. (Cross-listed as Mechanical Engineering 165.) Euler's, Bernoulli's, Navier-Stokes's, and energy equations; potential, viscous, and boundary-layer flows; separation flows; applications to various physical systems. Prerequisite: Engineering Science 8. Abedian, Rogers
166 Principles of Cell and Microbe Cultivation. In-depth examination of
microbial and mammalian cell cultivation and concomitant production of commercially
important products. Mechanism and methods of measurement and quantitative analysis of
growth, product formation, and nutrient utilization kinetics in characterizing and
optimizing for cell mass or product formation. Discussion of fundamental parameters
controlling bioreactor design and scale-up. Systems studied include production of proteins
in recombinant organisms, antibiotics, amino acids, and the cultivation of mammalian
cells. Prerequisite: consent. Kelley
168 Biotechnology Processing Projects Laboratory. (Cross-listed as Biology
168 and Biomedical Engineering 168.)
Laboratory experience with techniques in biotechnology processing: fermentation of
recombinant E. coli cells, hybridoma cell culture, purification of proteins and
antibodies and related analytical procedures. Laboratories accompanied by lectures and
relevant readings to cover the underlying principles. Counts as laboratory course for
biology major. Prerequisite: consent. Members of
the department
169 Seminar in Biotechnology. (Cross-listed as Biology 169 and Biomedical Engineering 169.) Seminar course. Journal articles on current biotechnology-related research are reviewed. Leading researchers in the field present seminars, and students assess future research directions based on in-depth review of articles and presentations. (Group A.) Kaplan
170 Technological Processes and the Environment. Survey of environmental problems arising from commonplace technologies, e.g., transportation, power generation, microelectronics processing, chemicals manufacturing. The course considers the introduction of chemicals into the environment and illustrates how to predict the fates of those chemicals in air-water-land-biota systems. Environmental and health consequences of products and the processes used for their manufacture are examined. Life Cycle Analysis methodologies are implemented in case studies. Development of technologies and policies for pollution prevention and a sustainable environment are discussed. Prerequisite: junior standing or consent. Flytzani-Stephanopoulos
173 Clean Energy Technologies and Policy Issues. (Cross-listed with Fletcher School.) This course considers current issues in power generation, identifying the technologies used to meet Clean Air Act regulations by the electric utilities and automobile manufacturers. Topics include the electric utility deregulation, distributed power sources, new energy markets, fuel efficiency, and global effects of fossil fuel use. Alternative fuels and engines will be examined from the point of view of technology readiness and global market penetration to curb air pollution and decrease carbon emissions. The costs of energy technologies and the global impacts of present policies in the U. S. and abroad will be evaluated. Flytzani-Stephanopoulos, Moomaw
175 Biomedical Engineering II. (Cross-listed as Engineering Science 175.) See Chemical and Biological Engineering 75 for course description. Includes a semester-long technical project and oral presentation. Prerequisite: consent. Kaplan
193, 194 Special Topics. Guided individual study of an approved topic to develop the art of self-teaching. Appraisal of the student's knowledge in the approved area will be based on a written and/or oral examination. Arrangements with a department member are required by the student prior to registration in the course. For master's degree candidates. Prerequisite: consent. Members of the department
291, 292 Graduate Seminar. Presentation of individual reports on basic topics to a seminar group for discussion and criticism. Members of the department
293, 294 Special Topics. Guided individual study of an approved topic. Designed to develop the art of self-teaching. Appraisal of the student's knowledge in the approved area based on a written and/or oral examination. Arrangements with a department member required prior to registration for the course. For doctoral degree candidates. Prerequisite: consent. Members of the department
295, 296 Master's Thesis. Guided research on a topic suitable for a master's thesis. Credit as arranged. Members of the department
297, 298 Ph.D. Thesis. Guided research on a topic suitable for a doctoral dissertation. Credit as arranged. Members of the department
401PT Master's Continuation, Part-time.
402FT Master's Continuation, Full-time.
501PT Doctoral Continuation, Part-time.
502FT Doctoral Continuation. Full-time.