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Research Areas
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Picture of portable In Vivo Flow Cytometer |
In Vivo Flow Cytometry
The main goal of this project is:
- To monitor quantitatively the number of specific
populations of circulating cells, such as white
blood and cancer cells and
- To
understand their role during disease progression or treatment.
Medical applications include non-invasive detection and monitoring of cancer patients.
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Development of Novel Optical Biomarkers for Early Cancer Detection
The main goal of this project is
to develop biomarkers that are based on endogenous
fluorescence and light scattering signals that can be correlated with molecular changes
that occur at the pre-cancer stage.
There is a particular emphasis on processes that are associated
with human papilloma virus infection. Ultimately, such tools can be used for early, noninvasive cancer detection.
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Noninvasive biochemical and morphological assessment or apoptotic epithelial cells
using autofluorescence microscopy |
Autofluorescence of
fibroblast
overlayed with
second harmonic
generation of collagen
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Preadipocytes on a
silk scaffold stained with live dead assay kit |
Optical Monitoring of Cell-Matrix Interactions in
Engineered Tissues
The main goal of this project is to use, optimize and develop high-resolution
imaging techniques with optical sectioning capabilities, such as confocal, multi-photon fluorescence and second
harmonic generation, to identify cell and matrix components non-invasively, using endogenous sources of optical contrast. Such
methods are used to monitor cell-matrix interactions within three-dimensional engineered tissues to
identify parameters that are
optimal for functional tissue development.
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