Former Lab Member
- Electromyography (EMG)
- Medical devices
Dr. Metallo holds a Ph.D. in Neuroscience from the Sackler
School of Biomedical Sciences at Tufts University School of Medicine
As part of her Ph.D. research, she developed a novel
platform technology aimed at monitoring bioelectrical signals such
as muscle activity. This technology was applied to acquire
motor patterns underlying adaptive locomotion in Manduca sexta,
a soft-bodied animal that is being used in the Trimmer lab as animal
model to develop biologically inspired soft robots.
A flexible, minimally invasive micro-electrode array was
specifically designed to collect high resolution muscle activity
from M. sexta muscles. Because of the high signal selectivity
of Dr. Metallo's electrode arrays and because M. sexta muscles
are innervated by a limited number of motor neurons, it was possible
to extract single excitatory junction potentials (EJP) from the
convoluted electromyographic (EMG) signals and thus identify the
firing patterns of single motor neurons. In this way, the neural
activity underlying adaptive locomotion was characterized with
single motor neuron resolution. Dr. Metallo's work represents one of
the most complete in vivo characterization of neural signals
directly related to behavioral output.
2013: Tufts University School of Medicine, Sackler School of Biomedical Sciences, Boston, MA
Ph.D. in Neuroscience
Thesis: Design, fabrication and development of a novel flexible electromyographic electrode array
to study neural control of adaptive locomotion in soft-bodied animals.
2012: Tufts University, Gordon Institute, Entrepreneurial Leadership Program, Medford, MA
Course Focus: High Technology Entrepreneurship and Business Planning.
2006: University of Tennessee, Knoxville, TN
M.S. in Physics
Thesis: Neutron diffraction study of heavy water intercalation in superconducting deuterated sodium cobaltate.
C. Metallo, and B.A. Trimmer,
"Orientation-dependent changes in single motor neuron activity
during adaptive soft-bodied locomotion". Brain Behavior and
Evolution (2014, in press).
C. Metallo, R.D. White, B.A. Trimmer, "Flexible
parylene-based microelectrode arrays for high resolution EMG
recordings in freely moving small animals". Journal of Neuroscience
Methods 195, 176–184 (2011)
M. Shin, A.P. Gerratt, C. Metallo, A. Brindle, B.P.
Kierstead, R.D. White, "Characterization of a micromachined
parylene-based thermal C-shape actuator", J. Micromech. Microeng.
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