Publications

Publications

Selected Papers

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  • Pare, J-F., Martyniuk, C. J., and Levin, M., (2017), Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis, Nature Regenerative Medicine, 2:15
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  • Blackiston, D., Khanh, V., and Levin, M., (2017), Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity, Nature Regenerative Medicine, 2:8
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  • Lobo, D., Lobikin, M., and Levin, M., (2016), Discovering novel phenotypes with automatically inferred dynamic models: partial melanocyte conversion in Xenopus, Nature Scientific Reports, in press
  • Levin, M., Pezzulo, G., and Finkelstein, J. M., (2016), Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form, Annual Review of Biomedical Engineering, in press
  • Tuszynski, J., Tilli, T. M., Levin, M., (2016), Ion channel and neurotransmitter modulators as electroceutical approaches to the control of cancer, Current Pharmaceutical Design, in press
  • Herrera-Rincon, C., Guay, J., and Levin, M., (2016), Bioelectrical coordination of cell activity toward anatomical target states: an engineering perspective on regeneration, in Regenerative Engineering and Developmental Biology: Principles and Applications, David Gardiner ed., CRC Press, Florida, in press
  • Golding, A., Guay, J. A., Herrera-Rincon, C., Levin, M., and Kaplan, D. L., (2016), A Tunable Silk Hydrogel Device for Studying Limb Regeneration in Adult Xenopus laevis, PLoS One 11, e0155618
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  • Lobo, D., Morokuma, J., and Levin, M., (2016), Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation, Bioinformatics, doi: 10.1093/bioinformatics/btw299
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  • D. S. Adams, S. G. M. Uzel, J. Akagi, D. Wlodkowic, V. Andreeva, P. C. Yelick, A. Devitt-Lee, J-F. Pare, and Michael Levin, (2016), "Bioelectric signaling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome", Journal of Physiology, 12: 3245-3270
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  • Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M., (2016), "Use of genetically encoded, light-gated ion translocators to control tumorigenesis", Oncotarget, 7(15): 19575-19588
  • Li, C., Levin, M., and Kaplan, D., (2016), "Bioelectric modulation of macrophage polarization", Scientific Reports, 6:21044, doi:10.1038/srep21044
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  • Sundelacruz, S., Levin M., and Kaplan, D. L., (2015), "Comparison of the depolarization response of human mesenchymal stem cells from different donors", Science Reports, 5:18279, doi:10.1038/srep18279
  • Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M., (2015),"Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms", International Journal of Molecular Sciences, 16: 27865–27896
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  • Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M., (2015), "Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation", Science Signaling, 8(397): ra99
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  • Levin, M., (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25: 3835-3850
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  • Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., and Kaplan, D. L., (2015), Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures, Brain and Behavior, 5(1): 24-38
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  • Pai, V., Lemire, J. M., Pare, J-F., Lin, G., Chen, Y., and Levin, M., (2015), Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation, Journal of Neuroscience, 35(10): 4366-4385
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  • Lobo, D., and Levin, M., (2015), Inferring regulatory networks from experimental morphological phenotypes: a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
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  • Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M., (2015), A novel method for inducing nerve growth via modulation of host resting potential, Neurotherapeutics, 12: 170-184
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  • Chernet, B., and Levin, M., (2014), Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range, Oncotarget, 5(10): 3287-3306
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  • Sundelacruz S, Levin M, Kaplan DL., (2013), Depolarization Alters Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells, Tissue Engineering Part A, 19 (17-18): 1889-908
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  • Chernet, B. T., and Levin, M., (2013), Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development, Disease Models and Mechanisms, 6: 595-607
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  • Levin, M., (2011), “The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer”, Regenerative Medicine, 6(6): 667-673
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  • Pai, V. P., Aw. S., Shomrat, T., Lemire, J. M., and M. Levin, (2011), “Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis”, Development, 139: 313-323
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  • Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and Omenetto, F., (2011), “Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes”, Biomedical Optics Express, 2(8): 2383-2391
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  • Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D., Branch, M. R., and Adams, D. S., (2011), “Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail”, PLoS One, 6(9): e24953. doi:10.1371/journal.pone.0024953
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  • Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M., (2011), “A second-generation device for automated training and quantitative behavior analyses of molecularly-tractable model organisms”, PLoS One, 5(12): e14370 (p. 1-20)
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  • Lange, C., Prenninger, S., Knuckles, P., Taylor V., Levin, M., and Calegari, F., (2011), “The H+ Vacuolar ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex”, Stem Cells and Development, 20(5): 1-8
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  • Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and M. Levin, (2010), "Induction of vertebrate regeneration by a transient sodium current”, Journal of Neuroscience, 30(39): 13192-13200
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  • N. J. Oviedo, J. Morokuma, P. Walentek, I. P. Kema, M. B. Gu, J. M. Ahn, J. S. Hwang, Takashi Gojobori, and M. Levin, (2010), "Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration”, Developmental Biology, 339: 188-199
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  • Blackiston, D. J., K. McLaughlin, and Levin, M., (2009), "Bioelectric controls of cell proliferation: ion channels, membrane voltage, and the cell cycle”, Cell Cycle, 8(21): 3519-3528
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  • Levin, M. (2009), "Bioelectric mechanisms in regeneration: Unique aspects and future perspectives", Seminars in Cell and Developmental Biology, 20: 543-556
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  • Levin, M., (2009), “Errors of Geometry: regeneration in a broader perspective”, Seminars in Cell and Developmental Biology, 20(6): 643-645
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  • Levin, M., Sundelacruz, S., Levin M., Kaplan, D. L., (2009), "Role of membrane potential in the regulation of cell proliferation and differentiation”, Stem Cell Reviews, 5(3): 231-46
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  • Tseng, A-S., and Levin, M., (2008), "Tail regeneration in Xenopus laevis as a model for understanding tissue repair”, Journal of Dental Research, 87(9): 806-816
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  • Morokuma, J., Blackiston, D., Adams, D. S., Trimmer, B., and Levin, M., (2008), "Modulation of potassium channel confers a hyper-proliferative, invasive phenotype on embryonic stem cells”, Proceedings of the National Academy of Science, 105(43): 16608-16613
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  • Sundelacruz, S., M. Levin, and D. L. Kaplan, (2008), "Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells”, PLoS One, 3(11): e3737, 1-15
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  • Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., (2007), "Apoptosis is required during early stages of tail regeneration in Xenopus laevis", Developmental Biology, 301: 62-69
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  • Adams, D. S., Masi, A., and Levin, M. (2007), "H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce tail regeneration", Development, 134: 1323-1335
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  • Oviedo, N. J., Levin, M., (2007), "smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis", Development, 134: 3121-3131
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  • Adams, D. S., and Levin, M., (2006), "Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets", Genesis, 44: 530-540
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