I am interested in the repair of camptothecin-induced DNA damage in Drosophila. Camptothecin interferes with the function of topoisomerase I and can create double-strand breaks or induce replication fork collapse. I am currently working to identify genes involved in the repair of this damage.

I am also interested in the function of Drosophila BRCA2. While little is known about Drosophila BRCA2, mutations in its human homolog confer a very significant predisposition to breast and ovarian cancer. Therefore, Drosophila BRCA2 likely serves some tumor suppressive role.