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Profile & Publications

Name: Kelly A. McLaughlin
Title: Associate Professor of Biology/Grad. Program Director
Degrees: Postdoc., Harvard Medical School, Boston, MA
Ph.D., University of Massachusetts at Amherst, MA
B.S., Wheaton College, MA
Expertise: Molecular Development (organogenesis)
Molecular and Cell Biology / Developmental Biology; organogenesis
Molecular events leading to cell differentiation and patterning during organ formation; signaling pathways in pronephric nephrogenesis (embryonic kidney) and cardiac development
Awards: RESEARCH GRANTS/FELLOWSHIPS
2014-2016 American Heart Association, NCRP Innovative Research Grant (KM, ML)
2009-2013 National Science Foundation Research Grant
2006 Faculty Research Award (FRAC-Marshall Fellowship)
2003-2007 American Heart Association Grant
National Kidney Foundation Fellowship, Harvard Medical School
Bunting Fellowship: Radcliffe Institute for Advanced Study, Harvard University
NRSA; National Institute of Health, Harvard Medical School

TEACHING AWARDS:
2008 - National Academies Education Fellow in the Life Sciences
2006 - Undergraduate Initiative in Teaching Award (UNITE 2006) Tufts University
1998 - Certificate of Distinction in Teaching, Harvard University and Radcliffe College
1991 - Graduate Associate Teaching Award, Univ. of Massachusetts

Email: kelly.mclaughlin@tufts.edu
Publications: (*denotes undergraduate)

Jewhurst, K., Levin, M., and McLaughlin, K.A. (2014) Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos. Journal of Cell Death 2014:7 25-31.

Caine, S.T. and McLaughlin, K.A. (2013) Regeneration of Functional Pronephric Proximal Tubules After Partial Nephrectomy in Xenopus laevis.Developmental Dynamics 242(3):219-29.

Lenkowski, J. R., Sanchez-Bravo, G. and McLaughlin, K. A. (2010) Low concentrations of atrazine, glyphosate, 2,4-dichlorophenoxyacetic acid (2,4-D), and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis. Journal of Environmental Sciences 23(1).

Lenkowski, J. R. and McLaughlin, K. A. (2010) Acute atrazine exposure disrupts matrix metalloproteinases and retinoid signaling during organ morphogenesis in Xenopus laevis Journal of Applied Toxicology. 30(6) 582-589.

Blackiston, D.J., McLaughlin, K., and Levin, M. (2009) Bioelectric controls of cell proliferation: Ion channels, membrane voltage, and the cell cycle. Cell Cycle. 8(21) 1-10. (Cover).

Miazga, C. and McLaughlin, K.A., (2009) Coordinating the timing of cardiac precursor cell development during gastrulation: a new role for Notch signaling. Developmental Biology. 333: 285–296.

Lenkowski, J., Reed, J.M., Deininger, L.*, and McLaughlin, K.A. (2008) Perturbation of Organogenesis by the Herbicide Atrazine in the Amphibian Xenopus laevis. Environmental Health Perspectives 116:223-230 (published online Nov. 22, 2007).

Bracken, C., Mizeracka, K.*, and McLaughlin, K.A. (2008) Patterning the embryonic kidney: BMP signaling mediates the differentiation of the pronephric tubules and duct. Developmental Dynamics 237:132–144 (published online Dec. 10, 2007).

Contakos, S. P., Gaydos, C., Pfeil, E.C.*, and McLaughlin, K.A. (2005). Subdividing the embryo: a role for Notch signaling during germ layer patterning in Xenopus laevis. Developmental Biology 288(1): 294-307.

Van Stry, M., McLaughlin, K. A., Ataliotis, P. and Symes, K. (2004). The mitochondrial-apoptotic pathway is triggered in Xenopus mesoderm cells deprived of PDGF receptor signaling during gastrulation. Developmental Biology Apr. 15; 268(1): 232-42.

Tonomura, N., McLaughlin, K. A., Grimm, L., Goldsby, R. A., and Osborne, B. A. (2003) Glucocorticoid-induced Apoptosis of Thymocytes: Requirement of Proteasome Dependent Mitochondrial Activity. Journal of Immunology. 170(5):2469-78.

Rones, M. S., Woda, J., Mercola, M., and McLaughlin, K. A. (2002). Isolation and Characterization of Xenopus Hey-1: A Downstream Mediator of Notch Signaling. Developmental Dynamics. 225: 554-560.

McLaughlin, K. A., Rones, M. S., and Mercola, M. (2000). Notch regulates cell fate in the developing pronephros. Developmental Biology. 227, 567-580.

Rones, M. S., McLaughlin, K. A., Raffin, M., and Mercola, M. (2000). Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127, 3865-3876.

McLaughlin, K. A., Osborne, B. A., and Goldsby, R. A. (1996). The role of oxygen in thymocyte apoptosis. Eur. J. Immunol. 26: 1170.

McLaughlin, K. A., Smith, S., Milligan, C., Bielke, W., Schwartz, L. M., and Osborne, B. A. (1996). β€œThe isolation and characterization of cell death genes.” In: The Handbook for Experimental Immunology.

Osborne, B. A., Smith, S., McLaughlin, K. A., Grimm, L., Morgan, G., and Goldsby, R. A. (1996). Genetic regulation of apoptosis in the mouse thymus. Mechanisms of Lymphocyte Activation and Immune Regulation. Gupta and Cohen, editors, p. 199-207. Plenum press.

Osborne, B. A., Smith, S., McLaughlin, K. A., Grimm, L., and Schwartz, L. (1995). Genes that regulate apoptosis in the mouse thymus. Journal of Cellular Biochemistry. 60:1.

Smith, S., McLaughlin, K. A., and Osborne, B. A. (1995). Programmed cell death in the thymus. In: Current Topics in Microbiology and Immunology. G. Kroemer and A. Martinez, editors, p. 147-162, Springer-Verlag.

Liu, Z.-G., Smith, S., McLaughlin, K. A., Schwartz, L. and Osborne, B.A. (1994). Apoptotic signals delivered through the T cell receptor of T cell hybrid require the immediate-early gene nur77. Nature. 367: 381.

Osborne, B. A., Smith, S., Liu, Z.-G., McLaughlin, K. A., and Schwartz, L. (1994). Transient transfection assays to examine the requirement of putative cell death genes. In: Methods in Cell Biology. L. Schwartz and B. Osborne, editors, p. 99-106, Academic Press.

Osborne, B.A., Smith, S., Liu, Z,-G., McLaughlin, K. A., Grimm, L., and Schwartz, L. (1994). Identification of genes induced during apoptosis in T lymphocytes. Immunol. Reviews. 142: 301.

Hobbies &
Interests:

Outdoor activities... Hiking, Scuba diving, Art (e.g. stained glass, floral design), cooking... and of course hanging with baby Max

Other education related activities: Science fair judge (MA state, MIT), Pathways program participant (Boston University; women in science), Teachers as Scholars program