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Publications

Planaria

Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M., (2017), Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous Bioelectric Gradients, Biophysical Journal, 112: 2231-2243
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Morokuma, J., Durant, F. R., Williams, K. B., Finkelstein, J. M., Blackiston, D. J., Clements, T., Reed, D. W., Roberts, M., Jain, M., Kimel, K., Trayger, S. A., Wolfe, B. E., and Levin, M., (2017), Planarian regeneration in space: persistent anatomical, behavioral, and bacteriological changes induced by space travel, Regeneration, 4: 85-102
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Neuhof, M., Levin, M., and Rechavi, O., (2016), Vertically and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria, Biology Open, 5, 1177-1188
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Sullivan, K. G., Emmons-Bell, M., and Levin, M., (2016), Physiological Inputs Regulate Species-Specific Anatomy During Embryogenesis And Regeneration, Communicative and Integrative Biology, 9:4, e1192733
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Lobo, D., Morokuma, J., and Levin, M., (2016), Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation, Bioinformatics, 32(17): 2681-2685
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Durant, F., Lobo, D., Hammelman, J., and Levin, M., (2016), Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form, Regeneration, 3(2): 78-102
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Lobo, D., and Levin, M., (2016), Computing a worm: reverse-engineering planarian regeneration, Advances in Unconventional Computing, Andrew Adamatzky ed., Vol. 2, Springer, p. 637-654

Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M., (2015), Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms, International Journal of Molecular Sciences, 16: 27865–27896
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Lobo, D., and Levin, M., (2015), Inferring regulatory networks from experimental morphological phenotypes: a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
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Shomrat, T., and Levin, M., (2013), An automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration, Journal of Experimental Biology, 216: 3799-3810
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Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M., (2013), Bioelectric signaling regulates head and organ size during planarian regeneration, Development, 140:313-322
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Lobo, D., Malone, T. J., and Levin, M., (2013), Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis, Biology Open, 2:156-169, doi: 10.1242/bio.20123400
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Lobo, D., Beane, W., and Levin, M., (2012), Modeling planarian regeneration: a primer for reverse-engineering the worm, PLoS Computational Biology, doi: 10.1371/journal.pcbi.1002481
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Beane, W. S., Tseng, A-S, Morokuma, J., and M. Levin, (2012), Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development, Stem Cells and Development, 21(12): 2085-2094
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Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M., (2011), A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Cell Chemistry and Biology, 18: 77-89
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Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M., (2011), A second-generation device for automated training and quantitative behavior analyses of molecularly-tractable model organisms. PLoS One, 5(12): e14370 (p. 1-20)
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N. J. Oviedo, J. Morokuma, P. Walentek, I. P. Kema, M. B. Gu, J. M. Ahn, J. S. Hwang, Takashi Gojobori, and M. Levin, (2010), Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration, Developmental Biology, 339: 188-199
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Oviedo, N. J., B. J. Pearson, M. Levin, and A. S. Alvarado, (2008), Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling, Disease Models and Mechanisms, 1: 131-143
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008), Live imaging of planarian membrane potential using DiBAC4(3). Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5055
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008), Gene knockdown in planarians using RNA interference. Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5054
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008), Establishing and maintaining a colony of planarians. Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5053
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Oviedo, N., and Levin, M., (2008), The planarian regeneration model as a context for the study of drug effects and mechanisms, in Planaria: A Model for Drug Action and Abuse, Raffa RB & Rawls SM (eds), RG Landes Co.: Austin, pp. 95-104

Nicolas, C.L., Abramson, C.I., and Levin, M. (2008), Analysis of behavior in the planarian model, in Planaria: A Model for Drug Action and Abuse, Raffa RB & Rawls SM (eds), RG Landes Co.: Austin, pp. 83-94

Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior, in Emerging Model Organisms, Cold Spring Harbor Press
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Hicks, C., Sorocco, D., and Levin, M., (2006), Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning. Journal of Neurobiology, 66(9): 977-90
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Nogi, T., Yuan, Y., Sorocco, D., Perez-Tomas, R., and M. Levin, (2005), Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica. Laterality, 10(1): 193-205
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Nogi, T., and Levin, M., (2005), Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration. Developmental Biology, 287: 314-335
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