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Publications

Asymmetry

Monsoro-Burq, A.H., and Levin, M., (2017), How the Chicken and the Egg Taught us to Tell Right From Left: Contribution of Avian Models to the Study of Invariant Asymmetry in Embryogenesis, International Journal of Developmental Biology, in press

Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Pare, J-F., Shi, N-Q., McLaughlin, K. A., and Levin, M., (2017), HCN4 Ion Channel Function is Required for Early Events that Regulate Anatomical Left-Right Patterning in a Nodal- and Lefty Asymmetric gene Expression-Independent Manner, Biology Open, 6: 1445-1457
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Blackiston, D. J., and Levin, M., (2017), Reversals of Bodies, Brains, and Behavior: quantitative analysis of laterality and its disturbance in model species, in "Lateralized Brain Functions", edited by Dr. Wolfgang Walz, Neuromethods 122: 668-695
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Levin, M., Klar, A. J. S., Ramsdell, A., (2016), Introduction to provocative questions in Left-Right asymmetry, Philosophical Transactions B, 371: 20150399
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McDowell, G., Rajadurai, S., and Levin, M., (2016), From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning, Philosophical Transactions B, 371: 20150409
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Davison A., McDowell G. S., Holden, J. M., Johnson H. F., Koutsovoulos G. D., Liu M. M., Hulpiau P., Van Roy F., Wade C. W., Banerjee R., Yang F., Chiba S., Davey J. W., Jackson, D. J., Levin M., and Blaxter, M. L., (2016), Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog, Current Biology, 26(5): 654-60
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McDowell, G. S., Lemire, J. M., Pare, J-F., Cammarata, G., Lowery, L. A., and Levin, M., (2016), Conserved roles for cytoskeletal components in determining laterality, Integrative Biology, 8: 267-286. DOI: 10.1039/C5IB00281H
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Dimonte, A., Adamatzky, A., Erokhin, V., (2016), On chirality of slime mould, BioSystems, 140: 23-27
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Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. M., and Levin, M., (2014), Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions, International Journal of Developmental Biology, 58: 799-809
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Vandenberg, L., Lemire, J., and Levin, M., (2013), It's Never too Early to get it Right: A Conserved Role for the Cytoskeleton in Left-Right Asymmetry, Communicative & Integrative Biology, 6(6): e27155
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Blackiston, D. J., and Levin, M., (2013), Inversion of left-right asymmetry alters performance of Xenopus tadpoles in nonlateralized cognitive tasks, Animal Behaviour, 86(2): 459–466
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Vandenberg, L. N., and Levin, M., (2013), A unified model for left-right asymmetry? Comparison and synthesis of molecular models of laterality, Developmental Biology, 379: 1-15
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Vandenberg, L. N., Morrie, R. D., Seebohm, G., Lemire, J. M., and Levin, M., (2013), Rab GTPases are required for early orientation of the left-right axis in Xenopus, Mechanisms of Development, 130:254-271
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Vandenberg, L. N., Lemire, J. M., and M. Levin, (2013), Serotonin has early, cilia-independent roles in Xenopus left-right patterning, Disease Models and Mechanisms, 6: 261-268
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Pai, V. P., Vandenberg, L. N,, Blackiston, D. J., and Levin, M., (2012), Neurally-derived tissues in Xenopus laevis embryos exhibit a consistent bioelectrical left-right asymmetry, Stem Cells International, Vol. 2012, Article ID 353491, 16 pages, doi:10.1155/2012/353491
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Lobikin, M., Wang, G., Xu, J-S, Hsieh, Y-W, Chuang, C-F, Lemire, J. M., and M. Levin, (2012), Early, non-ciliary role for microtubule proteins in left-right patterning is conserved across kingdoms, PNAS, 109(31): 12586-12591
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Vandenberg, L. N., and M. Levin, (2012), Polarity proteins are required for left-right axis orientation and twin-twin instruction. Genesis, 50: 219-234
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Carneiro, K., et al., and M. Levin, (2011), Histone deacetylase activity is necessary for left-right patterning during vertebrate development. BMC Developmental Biology, 11:29, doi:10.1186/1471-213X-11-29
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Vandenberg, L. N., B. W. Pennarola, and M. Levin, (2011), Low frequency vibrations disrupt left-right patterning in the Xenopus embryo. PLoS One, 6(8): e23306
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Levin, M. (2011), Left-Right Asymmetry in Embryonic Development: How epigenetic, biophysical forces and gene activity interplay to determine a major embryonic axis, in Topical Talks: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.
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Vandenberg, L. N., and M. Levin, (2010), Consistent left-right asymmetry cannot be Established by late organizers in Xenopus unless the late organizer is a conjoined twin, Development, 137, 1095-1105
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Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q., Carneiro, K., and Levin, M., (2010), The ATP-sensitive K+-channel (KATP) controls early left-right patterning in Xenopus and chick embryos. Developmental Biology, 346: 39-53
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Vandenberg, L. N., and Levin, M., (2010), Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry. Developmental Dynamics,, 239: 3131-3146
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Zhang, Y., and M. Levin, (2009), Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2, Genesis, 47(11): 719-728
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Morokuma, J., Blackiston, D., and Levin, M., (2008), KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus embryos, Cellular Physiology and Biophysics, 21: 345-360
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Aw, S., and Levin, M., (2008), What's Left in Asymmetry?, Developmental Dynamics, 237: 3453-3464
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Aw, S., and Levin, M., (2008), Is left-right asymmetry a form of planar cell polarity?, Development, 136: 355-366
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Vandenberg, L., and Levin, M., (2008), Perspectives and open problems in the early phases of left-right patterning, Seminars in Cell and Developmental Biology, 20: 456-463
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Aw, S., Adams, D. S., Qiu, D., and Levin, M., (2007), H,K-ATPase protein Localization and Kir4.1 function reveal concordance of 3 axes during early determination of left-right asymmetry, Mechanisms of Development, 125: 353-372
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Levin, M., Palmer, R., (2007), Left-right patterning from the inside out. BioEssays, 29: 271-287
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Levin, M., (2007), Gap junctional signaling in morphogenesis. Progress in Biophysics and Molecular Biology, 94 (1-2): 186-206
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Oviedo, N., and Levin, M. (2007), Gap junctions provide new links in Left-Right patterning, Cell, 129: 645-647
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Hibino, T., I. Yuichiro, Levin, M., and Nishino, A., (2006), Ion flow regulates left-right asymmetry in sea urchin development. Development, Genes and Evolution, 216(5): 265-76
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Shimeld, S. M., and Levin, M., (2006), Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux. Developmental Dynamics,, 235(6): 1543-1553
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Adams DS, Robinson KR, Fukumoto T, Yuan S, Yelick P, Kuo L, McSweeney M, Levin M., (2006), The V-ATPase generates asymmetric H+ flux required for correct LR asymmetry in chick and frog embryos. Development, 133: 1657-1671
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Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M., (2006), A Mathematical Model of Morphogen Electrophoresis through Gap Junctions. Developmental Dynamics,, 235: 2144-2159
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Levin, M., (2006), Is the Early Left-Right Axis like a Plant, a Kidney, or a Neuron? The Integration of Physiological Signals in Left-Right Asymmetry. Birth Defects Research (Part C), 78: 191-223
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Fukumoto, T., and Levin, M., (2005), Asymmetric expression of Syndecan-2 in early chick embryogenesis. MOD: Gene Expression Patterns, 5: 525-528
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Fukumoto, T., Kema, I., and Levin, M., (2005), Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Current Biology, 15: 794-803
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Nogi, T., Yuan, Y., Sorocco, D., Perez-Tomas, R., and M. Levin, (2005), Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica. Laterality, 10(1): 193-205
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Qiu, D., Cheng, S.M., Wozniak, L., McSweeney, M., Perrone, E., and Levin, M., (2005), Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry. Developmental Dynamics,, 234: 176-189
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Fukumoto, T., Blakely, R., and Levin, M., (2005), Serotonin transporters are a conserved, early mechanism in left-right patterning. Developmental Neuroscience, 27(6): 349 - 363
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Levin, M., (2005), Left-right asymmetry in embryonic development: a comprehensive review. Mechanisms of Development, 122(1): 3-25
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Levin, M., (2004), The embryonic origins of left-right asymmetry. Critical Reviews in Oral Biology and Medicine, 15(4): 197-206
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Adams, D. S., and Levin, M. (2004). Early Patterning of the Left/Right Axis. In Gastrulation: from cells to embryo (C. D. Stern, Ed.), pp. 403-417. Cold Spring Harbor, New York.
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Bunney, T. D., De Boer, A. H., and M. Levin, (2003), Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis, Development, 130: 4847-4858
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Levin, Michael, (2003), Left-Right Asymmetry in Amphibian Embryogenesis, in Developmental Biology, Vol. 6 of Biology of the Amphibia, edited by Harold Heatwole and Brenda Brizuela

M. Levin, (2003), Motor protein control of ion flux is an early step in embryonic Left-Right asymmetry. BioEssays, 25(10): 1002-1010
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Levin, Michael, T. Thorlin, K. Robinson, T. Nogi, and M. Mercola, (2002), H+/K+-ATPase activity comprises an early step of left-right asymmetry during development. Cell, 111: 77-89
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M. Mercola, and M. Levin, (2001), Left-Right asymmetry determination in vertebrates. Annual Review of Cell and Developmental Biology, 17: 779-805
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Levin, Michael, (2001), Asymmetry of Body and Brain: Embryological and Twin Studies. In: Smelser N, Baltes P (eds.) International Encyclopedia of the Social and Behavioral Sciences. Elsevier, Oxford, UK, pp. 853-9
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Levin, Michael, (1999), Twinning and embryonic left-right asymmetry. Laterality, 4(3): 197-208
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L. Zhu, M. J. Marvin, A. Gardiner, A. B. Lassar, M. Mercola, C. D. Stern, and M. Levin, (1999), Cerberus regulates left/right asymmetry of the embryonic head and heart. Current Biology, 9(17): 931-938
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Levin, Michael, and M. Mercola, (1999), Gap Junction-Mediated Transfer of Left-Right Patterning Signals in the Early Chick Blastoderm is Upstream of Shh Asymmetry in the Node. Development, 126: 4703-4714
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Levin, Michael, (1999), Left-right asymmetry in animal embryogenesis, in Advances in Biochirality, edited by G. Palyi, C. Zucchi, and L. Caglioti, ch. 12, p. 137-152, Elsevier: Amsterdam
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Levin, Michael, and M. Mercola, (1998), Gap junctions are involved in the early generation of left right asymmetry. Developmental Biology, 203(1): 90-105
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Levin, Michael, and M. Mercola, (1998), Events upstream of asymmetrical Nodal expression: reconciling the chick and frog. Developmental Genetics, 23(3): 185-193
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Levin, Michael, (1998), Left-Right asymmetry and the chick embryo. Seminars in Developmental Biology, 9: 67-76
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Levin, Michael, and M. Mercola, (1998), The compulsion of chirality. Genes & Development, 12: 763-769
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Levin, Michael, S. Pagan, D. Roberts, J. Cooke, M. Kuehn, and C. Tabin, (1997), Left/Right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Developmental Biology, 189: 57-67
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Levin, Michael, and N. Nascone, (1997), Two models of initial Left-Right Asymmetry Determination. Medical Hypotheses, 49: 429-435
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Levin, Michael, (1997), Left-Right Asymmetry in Embryonic Morphogenesis. BioEssays, 19(4): 287-296
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Levin, Michael, D. Roberts, L. Holmes, and C. Tabin, (1996), Laterality defects in Conjoined Twins. Nature, 385: 321
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Levin, Michael, R. L. Johnson, C. D. Stern, M. Kuehn, and C. Tabin, (1995), A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell, 82: 1-20
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