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Publications

All Peer-reviewed Publications

2014

Levin, M., (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25: 3835-3850
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Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M., (2014), A novel method for inducing nerve growth via modulation of host resting potential. Neurotherapeutics, in press

Jewhurst, K., Levin, M., and McLaughlin, K. A., (2014), Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos, Journal of Cell Death, 7: 25-31
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Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., Kaplan, D., (2014), Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures, Brain and Behavior, in press
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Adams, D.S., Lemire, J. M., Kramer, R. H., and Levin, M., (2014), Optogenetics in developmental biology: using light to control ion flux-dependent signals in Xenopus embryos, International Journal of Developmental Biology, in press
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Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. M., and Levin, M., (2014), Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions, International Journal of Developmental Biology, in press
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Zhu, F., Skommer, J., Huang, Y., Akagi, J., Adams, D. S., Levin, M., Hall, C. J., Crosier, P. S., and Wlodkowic, D., (2014), Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos, Cytometry A, 85A: 921-932
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Lobo, D., Feldman, E. B., Shah, M., Malone, T. J., and Levin, M., (2014), Limbform: a functional ontology-based database of limb regeneration experiments, Bioinformatics, in press

Lan J. Y., Williams C., Levin M., and Black L.D. III, (2014), Depolarization of Cellular Resting Membrane Potential Promotes Neonatal Cardiomyocyte Proliferation In Vitro, Cellular and Molecular Bioengineering, doi: 10.1007/s12195-014-0346-7
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Mustard, J., and Levin, M., (2014), Bioelectrical mechanisms for programming growth and form: taming physiological networks for soft body robotics, Soft Robotics, 1(3): 169-191
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Lobo, D., Feldman, E., Shah, M., Malone, T., and Levin, M., (2014), A bioinformatics expert system linking functional data to anatomical outcomes in limb regeneration, Regeneration, 1(2): 37-56
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Budnikova, M., Habig, J. W., Cornia, N., Levin. M., Lobo, D., and Andersen, T., (2014), Design of a flexible component gathering algorithm for converting cell-based models to graph representations for use in evolutionary search, BMC Bioinformatics, 15: 178
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Chernet, B., and Levin, M., (2014), Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range, Oncotarget, 5(10): 3287-3306
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Hernandez-Diaz S., and Levin, M., (2014), Alteration of bioelectrically-controlled processes in the embryo: a teratogenic mechanism for anticonvulsants, Reproductive Toxicology, 47: 111-114
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Pai, V., and Levin, M., (2014), Bioelectric Controls of Stem Cell Function, in Stem Cells, edited by F. Calegari and C. Waskow, CRC Press, Chapter 5, p. 106-145
Amazon book

Levin, M., (2014), Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration, Journal of Physiology, 592(11): 2295–2305.
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Lobo, D., Solano, M., and Bubenik, G. A., (2014), A linear-encoding model explains the variability of the target morphology in regeneration, Journal of the Royal Society Interface, 11: 20130918
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Lobikin, M., and Levin, M., (2014), Endogenous bioelectric cues as morphogenetic signals in vivo, chapter 15 in The Fields of Cells, edited by D. Fels and M. Cifra, p. 283-302
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2013

Levin, M., (2013), Remembrance of Brains Past, The Node
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Vandenberg, L., Lemire, J., and Levin, M., (2013), It's Never too Early to get it Right: A Conserved Role for the Cytoskeleton in Left-Right Asymmetry, Communicative & Integrative Biology, 6(6): e27155
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Rea, A. C., Vandenberg, L. N., Ball, R. E., Johnston, L. L., Zhu, Y., McLain, D. E., Lauderdale J. D., Levin, M., and Dore, T. M., (2013), Light activated serotonin for exploring its action in biological systems, Chemistry & Biology, 20: 1536–1546
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Sundelacruz S, Li C, Choi YJ, Levin M, Kaplan DL., (2013), Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone, Biomaterials, 34(28): 6695-705
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Sundelacruz S, Levin M, Kaplan DL., (2013), Depolarization Alters Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells, Tissue Engineering Part A, 19 (17-18): 1889-908
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Chernet, B., and Levin, M., (2013), Endogenous voltage potentials and the microenvironment: bioelectric signals that reveal, induce, and normalize cancer, Journal of Clinical and Experimental Oncology, S1: doi:10.4172/2324-9110.S1-002 [cover]
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Levin, M., (2013), Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities, WIREs Systems Biology and Medicine, 5(6): 657-676
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Shomrat, T., and Levin, M., (2013), An automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration, Journal of Experimental Biology, 216: 3799-3810
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Blackiston, D. J., and Levin, M., (2013), Inversion of left-right asymmetry alters performance of Xenopus tadpoles in nonlateralized cognitive tasks, Animal Behaviour, 86: 459-466
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Vandenberg, L. N., and Levin, M., (2013), A unified model for left-right asymmetry? Comparison and synthesis of molecular models of laterality, Developmental Biology, 379: 1-15 [cover]
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Lobo, D., Malone, T. J., and Levin, M., (2013), Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis, Biology Open, 2:156-169, doi: 10.1242/bio.20123400 [cover]
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Vandenberg, L. N., Morrie, R. D., Seebohm, G., Lemire, J. M., and Levin, M., (2013), Rab GTPases are required for early orientation of the left-right axis in Xenopus, Mechanisms of Development, 130:254-271 [cover]
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Adams, D. S., and Levin, M., (2013), Endogenous Voltage Gradients as Mediators of Cell-Cell Communication: Strategies for Investigating Bioelectrical Signals During Pattern Formation, Cell and Tissue Research, 352:95-122 [cover]
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Blackiston, D. J., and Levin, M., (2013), Ectopic eyes out side the head in Xenopus tadpoles provide sensory data for light-mediated learning, Journal of Experimental Biology, 216: 1031-1040
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Daniel Lobo; Taylor J. Malone; Michael Levin, (2013), Planform: an application and database of graph-encoded planarian regenerative experiments, Bioinformatics, 29(8): 1098-1100, doi: 10.1093/bioinformatics/btt088
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Koustubhan, P., Kaplan, D., and Levin, M., (2013), Humane anesthesia and pain management in amphibian limb surgery of Rana pipiens, CSHL Protocols, doi:10.1101/pdb.prot071977 [cover]
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Chernet, B. T., and Levin, M., (2013), Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development, Disease Models and Mechanisms, 6: 595-607
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Tseng, A-S., and Levin, M., (2013), Cracking the bioelectric code: probing endogenous ionic controls of pattern formation, Communicative and Integrative Biology, 6(1):1-8 [cover]
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Adams, D. S., Tseng, A-S. and M. Levin, (2013), Light-activation of the Archaerhodopsin H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level controls in vivo, Biology Open, 2(3): 306-313
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Vandenberg, L. N., Lemire, J. M., and M. Levin, (2013), Serotonin has early, cilia-independent roles in Xenopus left-right patterning, Disease Models and Mechanisms, 6: 261-268 [cover]
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Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M., (2013), Bioelectric signaling regulates head and organ size during planarian regeneration, Development, 140:313-322
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2012

Vandenberg, L. N., Stevenson, C., and M. Levin, (2012), Low frequency vibrations induce malformations in two aquatic species in a frequency-, waveform-, and direction-specific manner, PLoS One, 7(12): e51473
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Pai, V. P., Vandenberg, L. N,, Blackiston, D. J., and Levin, M., (2012), Neurally-derived tissues in Xenopus laevis embryos exhibit a consistent bioelectrical left-right asymmetry, Stem Cells International, Vol. 2012, Article ID 353491, 16 pages, doi:10.1155/2012/353491
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Lobikin, M., Chernet, B., Lobo, D., and Levin, M., (2012), Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo, Physical Biology, 9: 065002 [cover]
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Lobikin, M., Wang, G., Xu, J-S, Hsieh, Y-W, Chuang, C-F, Lemire, J. M., and M. Levin, (2012), Early, non-ciliary role for microtubule proteins in left-right patterning is conserved across kingdoms, PNAS, 109(31): 12586-12591
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Tseng, A-S., and M. Levin, (2012), Transducing bioelectrical signals into epigenetic pathways during tadpole tail regeneration, Anatomical Record, 295:1541-1551
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Levin, M., (2012), Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning, BioSystems, 109 (2012) 243­-261
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Vandenberg, L., Adams, D. S., and M. Levin, (2012), Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology, Developmental Dynamics, 241: 863-878 [cover]
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Blackiston, D. J., and M. Levin, (2012), Aversive training methods in Xenopus laevis: general principles, CSHL Protocols
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Beane, W. S., Tseng, A-S, Morokuma, J., and M. Levin, (2012), Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development, Stem Cells and Development, 21(12): 2085-2094 [cover]
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Chernet, B. T., Adams, D. S., and M. Levin, (2012), Photoconversion for Tracking the Dynamics of Cell Movement in Xenopus laevis Embryos, CSHL Protocols [cover]
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Chernet, B. T., and M. Levin, (2012), A versatile protocol for mRNA electroporation of Xenopus laevis embryos, CSHL Protocols, doi: 10.1101/pdb.prot067694 [cover]
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Adams, D. S., and M. Levin, (2012), General principles for measuring resting membrane potential and ion concentration using fluorescent bioelectricity reporters, CSHL Protocols, doi: 10.1101/pdb.top067710 [cover]
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Adams, D. S., and M. Levin, (2012), Measuring resting membrane potential using the fluorescent voltage reporters DiBAC4(3) and CC2-DMPE, CSHL Protocols, doi: 10.1101/pdb.prot067702
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Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M., (2012), Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development, 139: 313-323
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Levin, M., (2012), Molecular bioelectricity in developmental biology: new tools and recent discoveries, BioEssays, 34(3): 205-217 [cover]
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Vandenberg, L. N., and M. Levin, (2012), Polarity proteins are required for left-right axis orientation and twin-twin instruction. Genesis, 50: 219-234
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Levin, M., and Stevenson, C., (2012), Regulation of Cell Behavior and Tissue Patterning by Bioelectrical Signals: challenges and opportunities for biomedical engineering, Annual Reviews in Biomedical Engineering, 14: 295-323
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Lobo, D., Beane, W., and Levin, M., (2012), Modeling planarian regeneration: a primer for reverse-engineering the worm, PLoS Computational Biology [cover], doi: 10.1371/journal.pcbi.1002481
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2011

Blackiston, D., Adams, D. S., Lemire, J. M., Lobikin, M., and Levin, M., (2011), Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway. Disease Models and Mechanisms, 4: 67-85 [cover]
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Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M., (2011), A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Cell Chemistry and Biology, 18: 77-89
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Lange, C., Silvia, P., Knuckles, P., Taylor, V., Levin, M., Calegari, F., (2011), The H+ V-ATPase maintains neural stem cells in the developing mouse cortex. Stem Cells and Development, 20(5): 1-8
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Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M., (2011), A second-generation device for automated training and quantitative behavior analyses of molecularly-tractable model organisms. PLoS One, 5(12): e14370 (p. 1-20)
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Carneiro, K., et al., and M. Levin, (2011), Histone deacetylase activity is necessary for left-right patterning during vertebrate development. BMC Developmental Biology, 11:29 doi:10.1186/1471-213X-11-29
PubMed  |  PDF

Vandenberg, L. N., B. W. Pennarola, and M. Levin, (2011), Low frequency vibrations disrupt left-right patterning in the Xenopus embryo. PLoS One, 6(8): e23306
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Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and Omenetto, F., (2011), Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes. Biomedical Optics Express, 2(8): 2383-2391
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Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D., Branch, M. R., and Adams, D. S., (2011), Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail. PLoS One, 6(9): e24953.
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Tseng, A-S., Carneiro, K., Lemire, J. M., and Levin, M., (2011), HDAC activity is required during Xenopus tail regeneration. PLoS One, 6(10): e26382.
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Levin, M. (2011), Endogenous bioelectrical signals in Development, regeneration, and neoplasm, in Topical Talks: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.
Presentation

Levin, M. (2011), Left-Right Asymmetry in Embryonic Development: How epigenetic, biophysical forces and gene activity interplay to determine a major embryonic axis, in Topical Talks: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.
Presentation

Levin, M., (2011), Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm, in The Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer, C. Pullar ed., CRC Press.
Available here

Levin, M., (2011), The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, Developmental Biology, and cancer. Regenerative Medicine, 6(6): 667-673
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2010

N. J. Oviedo, J. Morokuma, P. Walentek, I. P. Kema, M. B. Gu, J. M. Ahn, J. S. Hwang, Takashi Gojobori, and M. Levin, (2010), Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration, Developmental Biology, 339: 188-199  [cover]
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Vandenberg, L. N., and M. Levin, (2010), Consistent left-right asymmetry cannot be Established by late organizers in Xenopus unless the late organizer is a conjoined twin, Development, 137, 1095-1105 [cover]
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 Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q., Carneiro, K., and Levin, M., (2010), The ATP-sensitive K+-channel (KATP) controls early left-right patterning in Xenopus and chick embryos. Developmental Biology, 346: 39-53
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Tseng, A-S., ne, W. S., Lemire, J. M., Masi, A., and M. Levin, (2010),
Induction of vertebrate regeneration by a transient sodium current
, Journal of Neuroscience, 30(39): 13192-13200 [cover]
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 Hechavarria, D., Dewilde, A., Braunhut, S., Levin, M., and Kaplan, D. K., (2010), BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration. Medical Engineering and Physics, 32: 1065-1073
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Blackiston, D., Vandenberg, L. N., and Levin, M., (2010), High-throughput Xenopus laevis immunohistochemistry using agarose sections. Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5532
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Vandenberg, L. N., and Levin, M., (2010), Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry. Developmental Dynamics, 239: 3131-3146 [cover]
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2009

Zhang, Y., and M. Levin, (2009), Particle tracking model of electrophoretic morphogen movement reveals stochastic dynamics of embryonic gradient, Developmental Dynamics, 238(8): 1923-1935
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Zhang, Y., and M. Levin, (2009), Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2, Genesis, 47(11): 719-728
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Levin, M. (2009), Bioelectric mechanisms in regeneration: Unique aspects and future perspectives. Seminars in Cell and Developmental Biology, 20: 543-556
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Levin, M., (2009), Errors of Geometry: regeneration in a broader perspective. Seminars in Cell and Developmental Biology, 20(6): 643-645
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Levin, M., (2009), Regeneration: recent advances, major puzzles, and biomedical opportunities. Seminars in Cell and Developmental Biology, 20(5): 515-516
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Levin, M., Sundelacruz, S., Levin M., Kaplan, D. L., (2009), Role of membrane potential in the regulation of cell proliferation and differentiation, Stem Cell Reviews, 5(3): 231-46
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Blackiston, D. J., K. McLaughlin, and Levin, M., (2009), Bioelectric controls of cell proliferation: ion channels, membrane voltage, and the cell cycle, Cell Cycle, 8(21): 3527-3536 [cover]
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2008

Morokuma, J., Blackiston, D., and Levin, M., (2008), KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus embryos, Cellular Physiology and Biophysics, 21: 345-360
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Oviedo, N. J., B. J. Pearson, M. Levin, and A. S. Alvarado, (2008), Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling, Disease Models and Mechanisms, 1: 131-143
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Morokuma, J., Blackiston, D., Adams, D. S., Trimmer, B., and Levin, M., (2008), Modulation of potassium channel confers a hyper-proliferative, invasive phenotype on embryonic stem cells, Proceedings of the National Academy of Science, 105(43): 16608-16613
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Sundelacruz, S., M. Levin, and D. L. Kaplan, (2008), Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells, PLoS One, 3(11): e3737, 1-15
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008), Live imaging of planarian membrane potential using DiBAC4(3). Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5055
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008), Gene knockdown in planarians using RNA interference. Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5054
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Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008), Establishing and maintaining a colony of planarians. Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5053
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Oviedo, N., and Levin, M., (2008), The planarian regeneration model as a context for the study of drug effects and mechanisms, in Planaria: A Model for Drug Action and Abuse, Raffa RB & Rawls SM (eds), RG Landes Co.: Austin, pp. 95-104

Nicolas, C.L., Abramson, C.I., and Levin, M. (2008), Analysis of behavior in the planarian model, in Planaria: A Model for Drug Action and Abuse, Raffa RB & Rawls SM (eds), RG Landes Co.: Austin, pp. 83-94

Aw, S., and Levin, M., (2008), What's Left in Asymmetry?, Developmental Dynamics, 237: 3453-3464
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Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior, in Emerging Model Organisms, Cold Spring Harbor Press
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Tseng, A-S., and Levin, M., (2008), Tail regeneration in Xenopus laevis as a model for understanding tissue repair, Journal of Dental Research, 87(9): 806-816
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Aw, S., and Levin, M., (2008), Is left-right asymmetry a form of planar cell polarity?, Development, 136: 355-366
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Vandenberg, L., and Levin, M., (2008), Perspectives and open problems in the early phases of left-right patterning, Seminars in Cell and Developmental Biology, 20: 456-463 [cover]
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2007

Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., (2007), Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Developmental Biology, 301: 62-69
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Adams, D. S., Masi, A., and Levin, M. (2007), H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce tail regeneration. Development, 134: 1323-1335 [cover]
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Oviedo, N. J., Levin, M., (2007), smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis. Development, 134: 3121-3131
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Aw, S., Adams, D. S., Qiu, D., and Levin, M., (2007), H,K-ATPase protein Localization and Kir4.1 function reveal concordance of 3 axes during early determination of left-right asymmetry, Mechanisms of Development, 125: 353-372
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Koustubhan, P., Sorocco, D., and Levin, M., (2007), Establishing and Maintaining a Xenopus laevis colony for research laboratories, in Source Book of Models for Biomedical Research, M. Conn ed., Humana Press

Levin, M., Palmer, R., (2007), Left-right patterning from the inside out. BioEssays, 29: 271-287
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Levin, M., (2007), Gap junctional signaling in morphogenesis. Progress in Biophysics and Molecular Biology, 94 (1-2): 186-206
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 Levin, M., (2007), Large-Scale Biophysics: Ion Flows and Regeneration. Trends in Cell Biology, 17(6): 262-271 [cover]
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Ingber, D., and Levin, M. (2007), What lies at the interface
of regenerative medicine and developmental biology?.
Development, 134: 2541-2547 [cover]
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Oviedo, N., and Levin, M. (2007), Gap junctions provide new links in Left-Right patterning, Cell, 129: 645-647
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2006

Hibino, T., I. Yuichiro, Levin, M., and Nishino, A., (2006), Ion flow regulates left-right asymmetry in sea urchin development. Development, Genes and Evolution, 216(5): 265-76
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Shimeld, S. M., and Levin, M., (2006), Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux. Developmental Dynamics, 235(6): 1543-1553
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Adams DS, Robinson KR, Fukumoto T, Yuan S, Yelick P, Kuo L, McSweeney M, Levin M., (2006), The V-ATPase generates asymmetric H+ flux required for correct LR asymmetry in chick and frog embryos. Development, 133: 1657-1671
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Hicks, C., Sorocco, D., and Levin, M., (2006), Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning. Journal of Neurobiology, 66(9): 977-90
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Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M., (2006), A Mathematical Model of Morphogen Electrophoresis through Gap Junctions. Developmental Dynamics, 235: 2144-2159
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Adams, D. S., and Levin, M., (2006), Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets. Genesis, 44: 530-540
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Adams, D., and Levin, M., (2006), Strategies and techniques for investigation of biophysical signals in patterning, in Analysis of Growth Factor signaling in Embryos, M. Whitman and A. K. Sater eds., pp. 177-214, Methods in Signal Transduction Series, CRC Press

Levin, M., Lauder, J., and Buznikov, G., (2006), Of minds and embryos: serotonin signaling as a pre-nervous morphogenetic mechanism. Developmental Neuroscience, 28:171-185 [cover]
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Levin, M., (2006), Is the Early Left-Right Axis like a Plant, a Kidney, or a Neuron? The Integration of Physiological Signals in Left-Right Asymmetry. Birth Defects Research (Part C), 78: 191-223
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2005

Fukumoto, T., and Levin, M., (2005), Asymmetric expression of Syndecan-2 in early chick embryogenesis. MOD: Gene Expression Patterns, 5: 525-528
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Fukumoto, T., Kema, I., and Levin, M., (2005), Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Current Biology, 15: 794-803
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Nogi, T., Yuan, Y., Sorocco, D., Perez-Tomas, R., and M. Levin, (2005), Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica. Laterality, 10(1): 193-205
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Qiu, D., Cheng, S.M., Wozniak, L., McSweeney, M., Perrone, E., and Levin, M., (2005), Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry. Developmental Dynamics, 234: 176-189
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Shin, J-B., Adams, D., Paukert, M., Siba, M., Sidi, S., Levin, M., Gillespie, P. G., and Grunder, S., (2005), Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells. P.N.A.S., 102(35): 12572-12577
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Gamer L. W., Nove J., Levin M., Rosen V., (2005), BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos. Developmental Biology, 285(1): 156-68
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Nogi, T., and Levin, M., (2005), Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration. Developmental Biology, 287: 314-335
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Fukumoto, T., Blakely, R., and Levin, M., (2005), Serotonin transporters are a conserved, early mechanism in left-right patterning. Developmental Neuroscience, 27(6): 349 - 363
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 Levin, M., (2005), Left-right asymmetry in embryonic development: a comprehensive review. Mechanisms of Development, 122(1): 3-25 [cover]
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2004

Levin, M., (2004), A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue. Journal of Biophysical and Biochemical Methods, 58: 85-96
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Levin, M., (2004), The embryonic origins of left-right asymmetry. Critical Reviews in Oral Biology and Medicine, 15(4): 197-206
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Adams, D. S., and Levin, M. (2004). Early Patterning of the Left/Right Axis. In Gastrulation: from cells to embryo (C. D. Stern, Ed.), pp. 403-417. Cold Spring Harbor, New York. PDF

 

2003

Bunney, T. D., De Boer, A. H., and M. Levin, (2003), Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis, Development, 130: 4847-4858
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Levin, Michael, (2003), Left-Right Asymmetry in Amphibian Embryogenesis, in Developmental Biology, Vol. 6 of Biology of the Amphibia, edited by Harold Heatwole and Brenda Brizuela

M. Levin, (2003), Electromagnetic fields in morphogenesis. Bioelectromagnetics, 24: 295-315
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M. Levin, (2003), Motor protein control of ion flux is an early step in embryonic Left-Right asymmetry. BioEssays, 25(10): 1002-1010
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2002

Levin, Michael, T. Thorlin, K. Robinson, T. Nogi, and M. Mercola, (2002), H+/K+-ATPase activity comprises an early step of left-right asymmetry during development. Cell, 111: 77-89
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J. Rutenberg, S. M. Cheng, and M. Levin, (2002), Early embryonic expression of ion channels and pumps in chick and Xenopus embryogenesis. Developmental Dynamics, 225(4): 469-484
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S. M. Cheng, I. Chen, and M. Levin, (2002), Katp channel activity is required for hatching in Xenopus. Developmental Dynamics, 225(4): 588-591
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Levin, Michael, (2002), Gap-junctional communication and embryonic development. Journal of Membrane Biology, 185 (3): 177-192
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2001

M. Mercola, and M. Levin, (2001), Left-Right asymmetry determination in vertebrates. Annual Review of Cell and Developmental Biology, 17: 779-805
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Levin, Michael, (2001), Asymmetry of Body and Brain: Embryological and Twin Studies. In: Smelser N, Baltes P (eds.) International Encyclopedia of the Social and Behavioral Sciences. Elsevier, Oxford, UK, pp. 853-9
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2000

Levin, Michael, and M. Mercola, (2000), Expression of Connexin30 in Xenopus embryos and its involvement in hatching gland function, Developmental Dynamics, 219(1): 96-101
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1999

Levin, Michael, (1999), Twinning and embryonic left-right asymmetry. Laterality, 4(3): 197-208
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L. Zhu, M. J. Marvin, A. Gardiner, A. B. Lassar, M. Mercola, C. D. Stern, and M. Levin, (1999), Cerberus regulates left/right asymmetry of the embryonic head and heart. Current Biology, 9(17): 931-938
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Levin, Michael, and M. Mercola, (1999), Gap Junction-Mediated Transfer of Left-Right Patterning Signals in the Early Chick Blastoderm is Upstream of Shh Asymmetry in the Node. Development, 126: 4703-4714
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Levin, Michael, (1999), Left-right asymmetry in animal embryogenesis, in Advances in Biochirality, edited by G. Palyi, C. Zucchi, and L. Caglioti, ch. 12, p. 137-152, Elsevier: Amsterdam
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Levin, Michael, (1999), Endogenous electromagnetic fields and radiations in regeneration, Development, and neoplasm, Proceedings of the First World Congress on the Effects of Electricity and Magnetism in the Natural World, Madeira, Portugal

 

1998

Levin, Michael, (1998), Follistatin mimics the endogenous streak inhibitory activity in early chick embryos. International Journal of Developmental Biology, 42: 553-559
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Levin, Michael, and M. Mercola, (1998), Gap junctions are involved in the early generation of left right asymmetry. Developmental Biology, 203(1): 90-105
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Levin, Michael, and M. Mercola, (1998), Events upstream of asymmetrical Nodal expression: reconciling the chick and frog. Developmental Genetics, 23(3): 185-193
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Levin, Michael, (1998), Left-Right asymmetry and the chick embryo. Seminars in Developmental Biology, 9: 67-76
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Levin, Michael, and M. Mercola, (1998), The compulsion of chirality. Genes & Development, 12: 763-769
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1997

 Levin, Michael, and Susan G. Ernst, (1997), DC magnetic field effects on early sea urchin development. Bioelectromagnetics, 18(3): 255-263
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Levin, Michael, S. Pagan, D. Roberts, J. Cooke, M. Kuehn, and C. Tabin, (1997), Left/Right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Developmental Biology, 189: 57-67
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Levin, Michael, and N. Nascone, (1997), Two models of initial Left-Right Asymmetry Determination. Medical Hypotheses, 49: 429-435
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Levin, Michael, (1997), Left-Right Asymmetry in Embryonic Morphogenesis. BioEssays, 19(4): 287-296 [cover]
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1996

Levin, Michael, D. Roberts, L. Holmes, and C. Tabin, (1996), Laterality defects in Conjoined Twins. Nature, 385: 321
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1995

Levin, Michael, and Ernst, Susan G., (1995), AC magnetic field effects on early sea urchin development. Bioelectromagnetics, 16: 231-240
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Levin, Michael, R. L. Johnson, C. D. Stern, M. Kuehn, and C. Tabin, (1995), A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell, 82: 1-20 [ cover]
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Levin, Michael, (1995), Use of Genetic Algorithms to solve biomedical Problems. M.D. Computing, 12(3): 193-198
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Levin, Michael, (1995), A genetic algorithm model of the evolution of animal communication. BioSystems, 36: 167-178
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Levin, Michael, (1995), Locating putative protein signal sequences using genetic algorithms, in Applications Handbook of Genetic Algorithms, Vol. 2, pp. 53-66, CRC Press: FL
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1994

Levin, Michael, A Julia set model of field-directed morphogenesis, (1994), Computer Applications in the Biosciences, 10(2): 85-103
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Levin, Michael, (1994), Discontinuous and alternate q-system fractals. Computers and Graphics, 18(6): 873-884
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1993

Levin, Michael, Current and potential applications of bioelectromagnetics in medicine, (1993), ISSEEM Journal, 4(1): 77-87
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Abstracts

  1. Blackiston Douglas; Adams Dany; Lemire Joan; et al., (2010), "Transmembrane voltage gradient in GlyR-expressing niche cells controls behavior of neural crest derivatives in vivo", Developmental Biology, 344(1): 526
  2. Morokuma Junji; Oviedo Nestor J.; Walentek Peter; et al., (2010), "Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration", Developmental Biology, 344(1): 522
  3. Tseng A. S., Beane W. S., Lemire J.M., et al. (2010), "NaV-mediated sodium transport is required for vertebrate appendage regeneration", Developmental Biology, 344(1): 519
  4. Beane W.S., Morokuma J., Levin M., (2010), "H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria", Developmental Biology, 344(1): 522
  5. Vandenberg, L., and Levin, M., (1010), "The Par6 complex is required for both early and late orientation of the left-right axis in Xenopus", Developmental Biology, 344(1): 426-427
  6. Beane W.S., Oviedo N.J., Adams D.S., Levin M. (2009), "H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria", Mechanisms of Development, 126 (Sup. 1): S294-S295
  7. Morokuma, J., and Levin, M., (2006), "Role of KvLQT-1/minK K+ channel in early embryonic patterning", Developmental Biology, 295(1): 451-
  8. M. Blum, A. Schweickert, T. Beyer, T. Weber, P. Andre, A. Fischer, Viebahn, M. Levin, (2006), "A leftward fluid flow precedes nodal induction in Xenopus", Developmental Biology, 295(1): 443
  9. Adams, D. S., Masi, A., Levin, M., (2006), "Xenopus tadpole tail regeneration requires the activity of the proton pump V- ATPase, and proton pumping is sufficient to partially rescue the loss of function phenotype" Developmental Biology, 295(1): 355-356
  10. Levin, M., Adams, D. S., Aw, S., Morokuma, J., Oviedo, N. J., (2006), "Bioelectrical controls of morphogenesis" Developmental Biology, 295(1):331-332
  11. Chen, I., and Levin, M., (2004). "The Role of KATP Channels in Development of Left-Right Asymmetry in Xenopus", Journal of Dental Research., 83: A1340.
  12. Nogi, T., Adams, D., and Levin, M., (2003),"Electrical Controls of Regeneration in Planaria", Developmental Biology, 259: 586
  13. Levin, M., (2003), "Electric Embryos: Endogenous Ion Fluxes and Voltage Gradients in Left—Right Asymmetry", Developmental Biology, 259: 482
  14. Adams, D., and Levin, M., (2003), "Elements of Left—Right Patterning: Gap Junctions, pH, and Membrane Voltage", Developmental Biology, 259: 482
  15. Fukumoto, T., and Levin, M., (2003), "Serotonin Is a Novel Very Early Signaling Mechanism in Left—Right Asymmetry", Developmental Biology, 259: 490
  16. Levin, M., and Mercola, M. (1999), "Gap junction-mediated transfer of left-right patterning signals", Molecular Biology of the Cell, 39: 1
  17. Pagan S. M., Levin M., Tabin C., (1997),"From left-right asymmetric gene expression to its morphological manifestations", Journal of Morphology, 232(3): 306
  18. Levin, M., Gonzalez, J. L., and Ernst, Susan G., (1991), "DC and AC magnetic field effects on early sea-urchin development", Biological Bulletin, 181: 511-