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Welcome to The Fuchs Lab. Proteins in the cell are subject to a wide array of chemical and enzymatic modifications after synthesis. These modifications dictate all aspects of protein function – from subcellular localization to lifetime in the cell. As such, post-translational modifications (PTMs) play crucial roles in regulating cellular function in both normal and disease states. In the Fuchs lab we are studying the mechanisms through which post-translational modifications regulate protein structure and protein function, such that we can understand fundamental cellular processes and explain how misregulation contributes to disease. Work in our lab is at the interface of Chemistry, Biology, and Engineering. Learn more >