Bio 50, Experiments in Molecular Biology. Similar to Biology 49, but investigating a series of laboratory problems using modern techniques of biotechnology. Gene cloning, recombinant protein expression, protein biochemistry, and immunochemistry are emphasized for teaching state-of-the-art laboratory skills and for reinforcing basic concepts of modern molecular biology. One laboratory session per week plus one discussion period. Prerequisites: sophomore standing and Biology 13 or equivalent. Open only to majors in biology, biochemistry, and chemical engineering. Spring. Fuhrman, Freudenreich, Gaudette

Bio 188 – Seminar in Molecular Biology and Genetics. Current topics in molecular biology, genetics and genomics, studied through readings from the original literature. Focus will be on studies recognized by the Nobel Prize Committee as pivotal to modern molecular biology and genetics. These studies and current research directions that follow from them will be covered using a combination of lectures, class discussion, and presentations. Selected topics of current interest to be covered include genome structure and polymorphisms as related to human disease, RNA functioning in the regulation of gene expression, and cell cycle regulation and cancer. (Group A) Fall. Freudenreich, Mirkin

Bio 243, Graduate Seminar in Molecular and Cell Biology. Topics may include regulation of gene transcription, chromatin structure and epigenetic regulation, mechanisms of chromosome segregation, DNA replication, recombination & repair, genome structure, genome stability and genome evolution, as well as the relationship of these topics to mutations and disease. Students will read and present papers from the current literature. Novel experimental techniques used to answer central questions will be emphasized. Prerequisite: Biology 105 or equivalent and consent (Group A/B). Fall. Freudenreich and members of the department.