Faculty & Research
Ekaterina "Kate" Mirkin
2006 - 2013 Postdoctoral fellow, Harvard University
1999 - 2006 Ph.D., Molecular Genetics, University of Illinois at
1994 - 1999 B.S./M.S., Molecular Biology, Moscow State University,
I am interested in chromosome biology, genome's structure and
function, maintenance of genomic stability and nuclear architecture.
My graduate work focused on transcription-replication collisions in
the cells of a bacterium, E. coli. As bacterial cells
simultaneously replicate and transcribe their chromosome, occasional
collisions between the replication forks and RNA polymerases can
occur. Such collisions can affect both replication and
transcription, as well as influence the structure of the genome in
the course of evolution. I have shown that RNA polymerase inhibits
the movement of the replication fork in vivo, if the
replication fork approaches it in the head-on direction.
During my postdoctoral training, I was using baker's yeast S.
cerevisiae as a model system to study interactions between
parts of chromosomes. In the recent years, it has become clear that
nuclear architecture plays an important role in gene expression and
maintenance of genomic stability, but molecular mechanisms, which
shape nuclear architecture, remain largely unknown. I have
demonstrated that self-dimerizing ("sticky") proteins can act as
tethers to physically bring parts of different chromosomes together.
Biology 41: Genetics
Biology 13L: Cells and organisms, laboratory coordinator
Biology 260-02: Preparation of teaching assistants to lead laboratory sections
< back to list of Faculty & Research