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Contact Info:
Department of Biology
Tufts University
Robinson Hall, Room 367
200 College Ave
Medford, MA 02155

Tel: 617.627.3726
Fax: 617.627.3805
Email Dr. Mirkin

Publications
Curriculum Vitae

Ekaterina "Kate" Mirkin
Lecturer
Genetics

Education

2006 - 2013 Postdoctoral fellow, Harvard University
1999 - 2006 Ph.D., Molecular Genetics, University of Illinois at Chicago
1994 - 1999 B.S./M.S., Molecular Biology, Moscow State University, Russia

Research Interests

I am interested in chromosome biology, genome's structure and function, maintenance of genomic stability and nuclear architecture.

My graduate work focused on transcription-replication collisions in the cells of a bacterium, E. coli. As bacterial cells simultaneously replicate and transcribe their chromosome, occasional collisions between the replication forks and RNA polymerases can occur. Such collisions can affect both replication and transcription, as well as influence the structure of the genome in the course of evolution. I have shown that RNA polymerase inhibits the movement of the replication fork in vivo, if the replication fork approaches it in the head-on direction.

During my postdoctoral training, I was using baker's yeast S. cerevisiae as a model system to study interactions between parts of chromosomes. In the recent years, it has become clear that nuclear architecture plays an important role in gene expression and maintenance of genomic stability, but molecular mechanisms, which shape nuclear architecture, remain largely unknown. I have demonstrated that self-dimerizing ("sticky") proteins can act as tethers to physically bring parts of different chromosomes together.

Courses

Biology 41: Genetics
Biology 13L: Cells and organisms, laboratory coordinator
Biology 260-02: Preparation of teaching assistants to lead laboratory sections



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