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Faculty & Research
Susan Koegel Education Ph.D., Biomedical Sciences, University of California, San Francisco, CA 2007 Research Interests My Ph.D. research was focused on the molecular mechanisms of
T cell activation. In particular, I studied ZAP-70, a protein
tyrosine kinase that is critical for proper T cell development
and function and has been shown to play a role in human disease.
I developed and analyzed an analog inhibitor system for ZAP-70,
which I used to more directly study the protein's function in
vitro and in vivo. The transgenic mouse that was developed to be
sensitive to the analog inhibitor will also be useful for
evaluating the clinical utility of a ZAP-70 inhibitor as a drug
candidate. |
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Ave., Medford, MA 02155 Tel: 617-627-3195 | Fax: 617-627-3805 | Department Email |
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