David E. Cochrane
Professor
Neural/endocrine signals on immune and inflammatory cell function

B.S., Cornell University - 1966
M.S., Reproductive Physiology, University of Vermont - 1968
Ph.D., Physiology and Biophysics, University of Vermont - 1971

Graduate Research Area: Cell Physiology

Research Interests

The general area of interest of my laboratory is the regulation of immune system cells by signals (e.g. peptides) released from neural and endocrine tissues. This regulatory effect is an important homeostatic mechanism whose proper balance is essential for the maintenance of health and well being.

Our work focuses on the mast cell and the fibroblast and how these cells are regulated by neuroendocrine peptides such as neurotensin (NT). Currently, we are studying the signal transduction pathways initiated by NT in these two cells and the cellular and physiologic consequences of NT’s action. We are also interested in understanding the role of mast cells in the exacerbating effects of stress on chronic inflammatory diseases. A third project concerns small peptides such as Histamine Releasing Peptide that are cleaved from large proteins like albumin by proteases secreted by mast cells and other inflammatory cells and the role of these peptides in inflammation.

Courses

Biology 115 and 116: General Physiology I and II
Biology 177: Seminar in Inflammation
Biology 49: Experiments in Physiology
Biology 134A: Neurobiology (summer only)

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