Harry Bernheim
Associate Professor, Chair
Human Physiology and Immunology

Publications

Cochrane,D.E. Carraway, R.E. Miller L.A., Feldberg R.S. and Bernheim, H. Histamine-Releasing Peptide (HRP) has proinflammatory effects and is present at sites of inflammation. Biochem. Pharmacol. 2003; 66 331-342.

Vaughn, L.K., Bernheim, H.A. and Kluger, M. J. (1974) Fever in the lizard Dipsosarus dorsalis.
Nature (London) 252: 475-474.

Bernheim, H.A. and Kluger, M. J. (1976) Fever and antipyresis in the lizard Dipsosarus dorsalis. Am. J. Physiol. 231: 198-203.

Bernheim, H.A. and Kluger, M.J. (1976) Fever: Effect of drug-induced antipyresis on survival.
Science 193: 237-239.

Bernheim, H.A. and Kluger, M.J. (1977) Endogenous pyrogen-like substance produced by
reptiles. J. Physiol. 267: 659:666.

Kluger, M.J., Bernheim, H.A., Vaughn, L.K., Foster, M.A. and D'Alecy, L.G. (1977) Evolution and adaptive value of fever. In: B. Cox, P. Lomax, A.J. Milton, E. Schonbaum (eds.) Drugs, Biogenic Amines and Body Temperature. pp 75-83.

Bernheim, H.A., Bodel, P.I., Askenase P. and Atkins. E. (1978) Effects of fever on host defense mechanisms after infection in the lizard Dipsosarus dorsalis. Brit. J. Exp. Pathol. 59: 76-84.

Atkins, E., Francis, L. and Bernheim. H. Pathogenesis of fever in delayed hypersensitivity: Role of monocytes. Infection and Immunity. 21: 813-820.

Bernheim, H.A., Block, L.H. and Atkins, E. (1979) Fever: pathogenesis, pathophysiology, and purpose. Annals of Int. Med. 91: 261-270.

Atkins, E., Askenase, P.W., Francis, L. and Bernheim, H.A. (1980) Release of an endogenous pyrogen from guinea pig leukocytes: the role of T lymphocytes and correlation with suppression (desensitization) of delayed hypersensitivity. J. Immunol. 125: 2069-2075.

Bernheim, H.A., Block, L.H., Francis, L. and Atkins, E. (1980) The role of human and guinea pit lymphocytes in the production of fever. In: B. Cox, P. Lomax, A.J. Milton, E. Schonbaum (eds.) Pharmacology of Temperature Regulation. pp 84-86.

Bernheim, H.A., Francis, L. and Atkins, E. (1980) Hypersensitivity fever: Cell-mediated and antibody-mediated mechanisms. In: J. Lipton (ed.) Fever. pp 11-21.

Bernheim, H.A., Block, L.H., Francis, L. and Atkins, E. (1980) Release of endogenous pyrogen-activating factor from concanavlin A- stimulated human lymphocytes. J. Exp. Med. 152: 1811-1816.

Bernheim, H.A., Gilbert, T.M. and Stitt, J.T. (1980) Prostaglandin E Levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature. J. Physiol. 301: 69-78.

Bernheim, H.A., Francis, L. and Atkins, E. (1980) Hypersensitivity fever: Cell-mediated and antibody-mediated mechanisms. In: Fever. J. Lipton (ed.). Raven Press. pp 11-21.

Dinarello, C.A. and Bernheim, H.A. (1981) Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J. Neurochem. 37: 702-708.

Dinarello, C.A., Bernheim, H.A., Duff. G.W., Lee, H.V., Nagabhushan, T.L., Hamilton, N.A. and Coceani, F. (1984) Mechanisms of fever induced by recombinant human interferon. J. Clin. Invest. 74: 906-913.

Shimada, S.G., Stitt, J.T. and Bernheim, H.A. (1984) Enhancement of the febrile response to endogenous pyrogen in rats by intravenously injected substances that stimulate phagocYtosis in reticular and endothelial system cells. In: J.R.S. Hales (ed.) Thermal Physiology. Raven Press, New York, pp 551-554.

Stitt, J.T., Shimada, S.G. and Bernheim, H.A. (1984) Microinjection of zymosan and lipopolysaccharide into the organum vasculosum laminae terminalis of rats enhances their febrile responsiveness to endogenous pyrogen. In: J.R.S. Hales (Ed.) Thermal Physiology. Raven Press, New York. pp 555-558.

Bernheim, H.A. and Dinarello, C.A. (1985) Effects of purified human interleukin-1 on the release of prostaglandin E2 from fibroblasts. Br. J. Rheum., Supplement, 24: 122-126.

Bernheim, H.A. and Dinarello, C.A. (1985) Effect of protein synthesis inhibitors on leukocytic pyrogen-induced in vitro hypothalamic prostaglandin production. Yale J. Biol. and Med. 58: 179-187.

Bernheim, H.A. (1985) Temperature regulation and fever. In: Reticuloendothelial System: A Comprehensive Treatise. Vo. 7B. S.M. Reichard and J.P. Filkins (eds.) Plenum Press. pp 339-353.

Dinarello, C.A., Bernheim, H.A., Cannon, J.G., LoPreste, C., Warner, S., Webb, A. and Auron, R.E. (1985) Furified, S-Met, H-Leu labeled human monocyte interleukin-1 (IL-1) with endogenous pyrogen activity. Br. J. Rheum., supplement. 24: 59-64.

Mier, J.W., Souza, L.M., Allegretta, M., Boone, T., Bernheim, H.A. and Dinarello, C.A. (1985) Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin and acute phase protein synthesis. J. Biol. Response Modifiers 4: 35-45.

Stitt, J.T., and Bernheim, H.A. (1985) Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits. J. Appl. Physiol. 59: 342-347.

Stitt, J.T., Shimada, S.G. and Bernheim, H.A. (1985) Comparison of febrile responsiveness of rats and rabbits to endogenous pyrogen. J. Appl. Physiol. 59: 1721- 1725.

Bernheim, H.A. (1986) Is prostaglandin E. involved in the pathogenesis of fever? Effects of interleukkin-1 on the release of prostaglandins. Yale J. Biol. and Med. 59: 131-138.

Dinarello, C.A., Cannon, J.G., Wolff, S.M., Bernheim, H.A., Beutlen, B., Cerami, A., Figari, I.S., Pallidino, Jr., M.A. and O'Connor, J.V. (2986) Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-1. J. Expo. Med. 163: 1433-1450.

Dinarello, C.A., Cannon, J.G., Mier, J.W., Bernheim, H.A., LoPreste, G., Lynn, D.L., Wolff, S.M. and Putney, S.D. (1986) Multiple Biological Activities of Human Recombinant interleukin-1. J. Clin. Invest. 77: 1734-1739.

Auron, P.E., Warner, S.J.C., Webb, A.C., Cannon, J.G., Bernheim, H.A., McAdam, K.J.P.W., Rosenwasser, L.J., LoPreste, G., Mucci, S.F., Dinarello, C.A. (1987) Studies on the Molecular Nature of human IL-1. J. Immunol. 138: 1987.

Mier, J.W., Vachino, G., Van Der Meer, J.W. M, Numerof, R.P., Adams, S., Cannon, J.G., Bernheim, H.A., Atkins, M.B., Parkinson, E.R., and Dinarello, C.A. Induction of Circulating Tumor Necrosis Factor (TNFa) as the Mechanism for the Febrile Response to Interluekin-2 (IL-2) in cancer Patients. J. of Clin. Immun. 8: 426-436.

Yoon, K.L. and Bernheim, H.A. (1987) Human recombinant interleukin-1 stimulates phosphatidylinositol turnover in human neuroblastoma cells. J. Leuk. Biology 42: 560.

D.E. Cochrane, R.E. Carraway, L.A. Miller, R.S. Feldberg, and H. Bernheim. Histamine-Releasing Peptide (HRP) has proinflammatory effects and is present at sites of inflammation. Biochem Pharmacol. 2003; 66: 331-342

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