Faculty & Research
Dany Adams
Research Professor
Biophysical Regulation in Development and Regeneration; Morphogenesis; Quantitative Imaging and Microscopy
Publications
Book
Michael Levin and Dany Spencer Adams Ahead of the Curve:
Hidden Breakthroughs in the Biosciences Vol I. 2016 (online), 2017
(hardcover). IOP Press. ISBN-13: 978-0750313278,
ISBN-10: 0750313277
Original Research
Brook T Chernet, Dany S Adams, Maria Lobikin, Michael Levin: Use
of genetically encoded, light-gated ion translocators to control tumorigenesis.
Oncotarget 03/2016; 7(15). DOI:10.18632/oncotarget.8036
Dany Spencer Adams, Sebastien G.M. Uzel, Jin Akagi, Donald
Wlodkowic, Viktoria Andreeva, Pamela Crotty Yelick, Adrian Devitt-Lee,
Jean-Francois Pare, Michael Levin: Bioelectric signalling via potassium
channels: A mechanism for craniofacial dysmorphogenesis in KCNJ2-associated
Andersen-Tawil Syndrome. The Journal of Physiology 02/2016; 594.
DOI:10.1113/JP271930
Maya Emmons-Bell, Fallon Durant, Jennifer Hammelman, Nicholas
Bessonov, Vitaly Volpert, Junji Morokuma, Kaylinnette Pinet, Dany S Adams,
Alexis Pietak, Daniel Lobo, Michael Levin: Gap Junctional Blockade
Stochastically Induces Different Species-Specific Head Anatomies in Genetically
Wild-Type Girardia dorotocephala Flatworms. International Journal of
Molecular Sciences 11/2015; 16(11). DOI:10.3390/ijms161126065
Dany Spencer Adams, Joan M. Lemire, Richard H. Kramer, Michael Levin: Optogenetics
in Developmental Biology: using light to control ion flux-dependent signals in
Xenopus embryos. The International Journal of Developmental Biology (2014)
58:851-861 ; DOI:10.1387/ijdb.140207ml
Adams, DS, Tseng, A-S, Levin, M.
Light-Activation of the Archaerhodopsin H+-pump reverses
age-dependent loss of vertebrate regeneration: sparking system-level controls in
vivo. Biology Open. 2013; doi:10.1242/ bio.20133665
Vandenberg, LN, Adams, DS, Levin, M.
Normalized Shape and Location of Perturbed Craniofacial Structures in the
Xenopus Tadpole Reveal an Innate Ability to Achieve Correct
Morphology. Dev Dyn 2012 241:863-878. DOI: 10.1002/dvdy.23770.
Vandenberg LN, Morrie RD, Adams DS.
V-ATPase-dependent ectodermal voltage and ph regionalization are required for
craniofacial morphogenesis. Dev Dyn 2011 Aug.;240(8):1889�1904.
Mondia JP, Levin M, Omenetto FG, Orendorff RD, Branch MR,
Adams DS. Long-distance signals are
required for morphogenesis of the regenerating Xenopus tadpole tail, as shown by
femtosecond-laser ablation. PLoS ONE 2011;6(9):e24953.
Mondia JP, Adams DS, Orendorff RD,
Levin M, Omenetto FG. Patterned femtosecond-laser ablation of Xenopus laevis
melanocytes for studies of cell migration, wound repair, and developmental
processes. Biomed Opt Express 2011 Aug.;2(8):2383�2391.
Blackiston D, Adams DS, Lemire JM,
Lobikin M, Levin M. Transmembrane potential of GlyCl-expressing instructor cells
induces a neoplastic-like conversion of melanocytes via a serotonergic pathway.
Disease Models & Mechanisms 2011 Jan.;4(1):67�85.
Beane WS, Morokuma J, Adams DS, Levin
M. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is
required for planarian head regeneration. Chemistry & Biology 2011
Jan.;18(1):77�89.
Morokuma J, Blackiston D, Adams DS,
Seebohm G, Trimmer B, Levin M. Modulation of potassium channel function confers
a hyperproliferative invasive phenotype on embryonic stem cells. P Natl Acad Sci
Usa 2008;105(43):16608�16613.
Aw S, Adams DS, Qiu D, Levin M. H,K-ATPase
protein localization and Kir4.1 function reveal concordance of three axes during
early determination of left-right asymmetry. Mech Dev 2008
Feb.;125(3-4):353�372.
Tseng A-S, Adams DS, Qiu D,
Koustubhan P, Levin M. Apoptosis is required during early stages of tail
regeneration in Xenopus laevis. Dev Biol 2007 Jan.;301(1):62�69.
Adams DS, Masi A, Levin M. H+
pump-dependent changes in membrane voltage are an early mechanism necessary and
sufficient to induce Xenopus tail regeneration. Development 2007
Apr.;134(7):1323�1335.
Adams DS, Robinson KR, Fukumoto T,
Yuan S, Albertson RC, Yelick P, Kuo L, McSweeney M, Levin M. Early, H+-V-ATPase-dependent
proton flux is necessary for consistent left-right patterning of non-mammalian
vertebrates. Development 2006 May;133(9):1657�1671.
Adams DS, Levin M. Inverse drug
screens: a rapid and inexpensive method for implicating molecular targets.
Genesis 2006 Nov.;44(11):530�540.
Shin J-B, Adams D, Paukert M, Siba M,
Sidi S, Levin M, Gillespie PG, Gr�nder S. Xenopus TRPN1 (NOMPC) localizes to
microtubule-based cilia in epithelial cells, including inner-ear hair cells. P
Natl Acad Sci Usa 2005 Aug.;102(35):12572�12577.
Molg� J, Colasantei C, Adams DS,
Jaimovich E. IP3 receptors and Ca2+ signals in adult skeletal muscle
satellite cells in situ. Biol Res 2004;37(4):635�639.
Molgo J, Colasante C, Adams DS,
Jaimovich E. Receptors and Ca2+ signals in adult skeletal muscle
satellite cells in situ. Biol Res 2004;37(4):635�639.
Powell JA, Molg� J, Adams DS,
Colasante C, Williams A, Bohlen M, Jaimovich E. IP3 receptors and
associated Ca2+ signals localize to satellite cells and to components
of the neuromuscular junction in skeletal muscle. Journal of Neuroscience 2003
Sep.;23(23):8185�8192.
Powell JA, Carrasco MA, Adams DS,
Drouet B, Rios J, M�ller M, Estrada M, Jaimovich E. IP(3) receptor function and
localization in myotubes: an unexplored Ca(2+) signaling pathway in skeletal
muscle. J Cell Sci 2001 Oct.;114(Pt 20):3673�3683.
Powell J, Carrasco M, Adams DS,
Drouet B, Rios J, Muller M, Estrada M, Jaimovich E. How your muscles know you've
been working out: The IP3 pathway as a developmental signal in skeletal muscle.
Dev Biol 2001;235(1):180�180.
Adams DS. Mechanisms of cell shape
change: the cytomechanics of cellular response to chemical environment and
mechanical loading. J Cell Biol 1992 Apr.;117(1):83�93.
Reviews
Zhu, F., J. Skommer,
Y. Huang, J. Akagi, Adams DS, M.
Levin, C.J. Hall, P.S. Crosier and D. Wlodkowic (2014) Fishing on Chips:
Up-and-Coming Technological Advaces in Analysis of Zebrafish and Xenopus
Embryos. Cytometry Par A. 85: 921-932.
Adams, DS, Levin, M. Endogenous voltage
gradients as mediators of cell-cell communication: strategies for investigating
bioelectrical signals during pattern formation. Cell Tissue Res. 2013;
352(1): 95-122. DOI
10.1007/s00441-012-1329-4
Adams, DS, Levin, M. General Principles
for Measuring Resting Membrane Potential and Ion Concentration Using Fluorescent
Bioelectricity Reporters. Cold
Spring Harb Protoc; 2012;
doi:10.1101/pdb.top067710.
Adams DS. A new tool for tissue
engineers: ions as regulators of morphogenesis during development and
regeneration. Tissue Eng Pt A 2008 Sep.;14(9):1461�1468.
Protocols
Adams, DS, Levin, M. Measuring Resting
Membrane Potential Using he Fluorescent Voltage Reporters DiBAC4(3)
and CC2-DMPE. Cold Spring Harb Protoc; 2012; doi:10.1101/pdb.prot067702
Oviedo NJ, Nicolas CL, Adams DS,
Levin M. Planarians: a versatile and powerful model system for molecular studies
of regeneration, adult stem cell regulation, aging, and behavior. Cold Spring
Harb Protoc; 2008;2008:pdb.emo101.
Oviedo NJ, Nicolas CL, Adams DS,
Levin M. Live Imaging of Planarian Membrane Potential Using DiBAC4(3).
Cold Spring Harb Protoc; 2008;2008:pdb.prot5055.
Oviedo NJ, Nicolas CL, Adams DS,
Levin M. Gene knockdown in planarians using RNA interference. Cold Spring Harb
Protoc; 2008;2008:pdb.prot5054.
Oviedo NJ, Nicolas CL,
Adams DS, Levin M. Establishing and
maintaining a colony of planarians. Cold Spring Harb Protoc;
2008:pdb.prot5053.
Books
Adams DS, Lab Math: A
Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at
the Bench. 1st and 2nd Ed. 2003, 2013. Cold Spring Harbor, NY: Cold Spring
Harbor Laboratory Press.
Book Chapters
Adams DS. Using optogenetics to induce regeneration of a vertebrate
appendage. In: OPTOGENETICS: From Neuronal Function to Mapping & Disease
Biology. K. Appasani Ed. 2015
Cambridge University Press.
Adams DS and M.
Levin, Strategies and Techniques for Investigation of Biophysical Signals in
Patterning, in Analysis of growth factor signaling in embryos, M. Whitman and
A.K. Sater, Editors. 2007, CRC/Taylor & Francis: Boca Raton, FL. p. 435 p.
Adams DS and M.
Levin, Early Patterning of the Left/Right Axis, in Gastrulation, C.D. Stern,
Editor 2004, Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. p. 16.
Koehl, M.A.R., Adams DS and R.
Keller, Mechanical Development of the Notochord in Xenopus Early Tail-Bud
Embryos, in Biomechanics of Active Movement and Deformation of Cells, N. Akkaş,
Editor 1989, Springer-Verlag: Berlin.
Adams DS, Dynamic
Mechanical Properties of Physarum Cytoplasm, in Biomechanics of Active Movement
and Deformation of Cells, N. Akkaş, Editor 1989, Springer-Verlag: Berlin.
Pedagogy
Adams DS. Teaching
critical thinking in a developmental biology course at an American liberal arts
college. Int J Dev Biol 2003;47(2-3):145�151.
Adams DS A method for
teaching controls. Dev Biol 2000;222(1):235�235.
Conference Abstracts/Proceedings
Adams DS, Blackiston,
D., Lemire, J. Levin, M. Evidence of a Signaling Role for Developmentally
Regulated Control of Ectodermal Cell Membrane Voltage: Human Craniofacial
Dysmorphias and Tadpole Faces.
Neural Crest & Cranial Placodes Gordon Research Conference. (2013)
Vandenberg, L.N.
Adams DS Dramatic Changes in Membrane Voltage Prefigure Craniofacial Morphogenesis.
Poster. Gordon Research Conference. 2010.
Adams DS A new tool
for tissue engineers: ions as regulators of morphogenesis during development and
regeneration. Tissue Engineering Part A. 2008:14(9): 1461-1468.
Levin, M., Adams DS, S. Aw, J.
Morokuma, and N. Oviedo. Bioelectrical Controls of Morphogenesis. in
Developmental Biology. 2006.
Adams DS., A. Masi,
and M. Levin. Xenopus tadpole tail regeneration requires the activity of the
proton pump V-ATPase, and proton pumping is sufficient to partially rescue the
loss of function phenotype. in Developmental Biology. 2006.
Adams DS., T.
Fukumoto, L. Kuo, and M. Levin. Ductin and Ion Flux in Pattern Formation. in The
2004 Northeast Regional meeting of The Society for Developmental Biology. 2004.
Marine Biological Laboratory, Woods Hole, MA.
Nogi, T., Adams
DS, and M. Levin. Electric controls of regeneration in planaria.
in Developmental Biology. 2003.
Adams DS. and M.
Levin. Elements of Left-Right Patterning: Gap Junctions, pH, and Membrane
Voltage. in Developmental Biology. 2003.
Powell, J.A.,
Adams DS, J. Molgo,
C. Colasante, A. Willams, M. Bohlen, and E. Jaimovich. IP3 receptors and
associated calcium signals localize to components of the neuromuscular junction
and satellite cells in skeletal muscle. in Biophysical Journal. 2002.
Powell, J.A., M.A. Carrasco,
Adams DS,
B. Drouet, J. Rios, M. Muller, M. Estrada, and E. Jaimovich. How your muscles
know you've been working out: the IP3 pathway as a developmental signal in
skeletal muscle. in Developmental Biology. 2001.
Adams DS. A Method
for Teaching Controls. in Developmental Biology. 2000.
Powell, J.A.,
Adams DS, and E.
Jaimovich. Subcellular Localization of IP3R in Cultured Skeletal Muscle. in
Biophysical Society. 1999. Baltimore, MD: Biophysical Journal.
< back to Prof. Adams' profile page
|