Faculty & Research

Dany Adams
Research Professor
Biophysical Regulation in Development and Regeneration; Morphogenesis; Quantitative Imaging and Microscopy

Publications

Book

Michael Levin and Dany Spencer Adams Ahead of the Curve: Hidden Breakthroughs in the Biosciences Vol I. 2016 (online), 2017 (hardcover). IOP Press. ISBN-13: 978-0750313278, ISBN-10: 0750313277

Original Research

Brook T Chernet, Dany S Adams, Maria Lobikin, Michael Levin: Use of genetically encoded, light-gated ion translocators to control tumorigenesis. Oncotarget 03/2016; 7(15). DOI:10.18632/oncotarget.8036

Dany Spencer Adams, Sebastien G.M. Uzel, Jin Akagi, Donald Wlodkowic, Viktoria Andreeva, Pamela Crotty Yelick, Adrian Devitt-Lee, Jean-Francois Pare, Michael Levin: Bioelectric signalling via potassium channels: A mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome. The Journal of Physiology 02/2016; 594. DOI:10.1113/JP271930

Maya Emmons-Bell, Fallon Durant, Jennifer Hammelman, Nicholas Bessonov, Vitaly Volpert, Junji Morokuma, Kaylinnette Pinet, Dany S Adams, Alexis Pietak, Daniel Lobo, Michael Levin: Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms. International Journal of Molecular Sciences 11/2015; 16(11). DOI:10.3390/ijms161126065

Dany Spencer Adams, Joan M. Lemire, Richard H. Kramer, Michael Levin: Optogenetics in Developmental Biology: using light to control ion flux-dependent signals in Xenopus embryos. The International Journal of Developmental Biology (2014) 58:851-861 ; DOI:10.1387/ijdb.140207ml

Adams, DS, Tseng, A-S, Levin, M. Light-Activation of the Archaerhodopsin H⁺-pump reverses age-dependent loss of vertebrate regeneration: sparking system-level controls in vivo. Biology Open. 2013; doi:10.1242/ bio.20133665

Vandenberg, LN, Adams, DS, Levin, M. Normalized Shape and Location of Perturbed Craniofacial Structures in the Xenopus Tadpole Reveal an Innate Ability to Achieve Correct Morphology. Dev Dyn 2012 241:863-878. DOI: 10.1002/dvdy.23770.

Vandenberg LN, Morrie RD, Adams DS. V-ATPase-dependent ectodermal voltage and ph regionalization are required for craniofacial morphogenesis. Dev Dyn 2011 Aug.;240(8):1889�1904.

Mondia JP, Levin M, Omenetto FG, Orendorff RD, Branch MR, Adams DS. Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail, as shown by femtosecond-laser ablation. PLoS ONE 2011;6(9):e24953.

Mondia JP, Adams DS, Orendorff RD, Levin M, Omenetto FG. Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes. Biomed Opt Express 2011 Aug.;2(8):2383�2391.

Blackiston D, Adams DS, Lemire JM, Lobikin M, Levin M. Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway. Disease Models & Mechanisms 2011 Jan.;4(1):67�85.

Beane WS, Morokuma J, Adams DS, Levin M. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chemistry & Biology 2011 Jan.;18(1):77�89.

Morokuma J, Blackiston D, Adams DS, Seebohm G, Trimmer B, Levin M. Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. P Natl Acad Sci Usa 2008;105(43):16608�16613.

Aw S, Adams DS, Qiu D, Levin M. H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry. Mech Dev 2008 Feb.;125(3-4):353�372.

Tseng A-S, Adams DS, Qiu D, Koustubhan P, Levin M. Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Dev Biol 2007 Jan.;301(1):62�69.

Adams DS, Masi A, Levin M. H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. Development 2007 Apr.;134(7):1323�1335.

Adams DS, Robinson KR, Fukumoto T, Yuan S, Albertson RC, Yelick P, Kuo L, McSweeney M, Levin M. Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development 2006 May;133(9):1657�1671.

Adams DS, Levin M. Inverse drug screens: a rapid and inexpensive method for implicating molecular targets. Genesis 2006 Nov.;44(11):530�540.

Shin J-B, Adams D, Paukert M, Siba M, Sidi S, Levin M, Gillespie PG, Gr�nder S. Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. P Natl Acad Sci Usa 2005 Aug.;102(35):12572�12577.

Molg� J, Colasantei C, Adams DS, Jaimovich E. IP3 receptors and Ca²⁺ signals in adult skeletal muscle satellite cells in situ. Biol Res 2004;37(4):635�639.

Molgo J, Colasante C, Adams DS, Jaimovich E. Receptors and Ca²⁺ signals in adult skeletal muscle satellite cells in situ. Biol Res 2004;37(4):635�639.

Powell JA, Molg� J, Adams DS, Colasante C, Williams A, Bohlen M, Jaimovich E. IP₃ receptors and associated Ca²⁺ signals localize to satellite cells and to components of the neuromuscular junction in skeletal muscle. Journal of Neuroscience 2003 Sep.;23(23):8185�8192.

Powell JA, Carrasco MA, Adams DS, Drouet B, Rios J, M�ller M, Estrada M, Jaimovich E. IP(3) receptor function and localization in myotubes: an unexplored Ca(2+) signaling pathway in skeletal muscle. J Cell Sci 2001 Oct.;114(Pt 20):3673�3683.

Powell J, Carrasco M, Adams DS, Drouet B, Rios J, Muller M, Estrada M, Jaimovich E. How your muscles know you've been working out: The IP3 pathway as a developmental signal in skeletal muscle. Dev Biol 2001;235(1):180�180.

Adams DS. Mechanisms of cell shape change: the cytomechanics of cellular response to chemical environment and mechanical loading. J Cell Biol 1992 Apr.;117(1):83�93.

Reviews

Zhu, F., J. Skommer, Y. Huang, J. Akagi, Adams DS, M. Levin, C.J. Hall, P.S. Crosier and D. Wlodkowic (2014) Fishing on Chips: Up-and-Coming Technological Advaces in Analysis of Zebrafish and Xenopus Embryos. Cytometry Par A. 85: 921-932.

Adams, DS, Levin, M. Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation. Cell Tissue Res. 2013; 352(1): 95-122. DOI 10.1007/s00441-012-1329-4

Adams, DS, Levin, M. General Principles for Measuring Resting Membrane Potential and Ion Concentration Using Fluorescent Bioelectricity Reporters. Cold Spring Harb Protoc; 2012; doi:10.1101/pdb.top067710.

Adams DS. A new tool for tissue engineers: ions as regulators of morphogenesis during development and regeneration. Tissue Eng Pt A 2008 Sep.;14(9):1461�1468.

Protocols

Adams, DS, Levin, M. Measuring Resting Membrane Potential Using he Fluorescent Voltage Reporters DiBAC₄(3) and CC2-DMPE. Cold Spring Harb Protoc; 2012; doi:10.1101/pdb.prot067702

Oviedo NJ, Nicolas CL, Adams DS, Levin M. Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior. Cold Spring Harb Protoc; 2008;2008:pdb.emo101.

Oviedo NJ, Nicolas CL, Adams DS, Levin M. Live Imaging of Planarian Membrane Potential Using DiBAC₄(3). Cold Spring Harb Protoc; 2008;2008:pdb.prot5055.

Oviedo NJ, Nicolas CL, Adams DS, Levin M. Gene knockdown in planarians using RNA interference. Cold Spring Harb Protoc; 2008;2008:pdb.prot5054.

Oviedo NJ, Nicolas CL, Adams DS, Levin M. Establishing and maintaining a colony of planarians. Cold Spring Harb Protoc; 2008:pdb.prot5053.

Books

Adams DS, Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench. 1st and 2nd Ed. 2003, 2013. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

Book Chapters

Adams DS. Using optogenetics to induce regeneration of a vertebrate appendage. In: OPTOGENETICS: From Neuronal Function to Mapping & Disease Biology. K. Appasani Ed. 2015 Cambridge University Press.

Adams DS and M. Levin, Strategies and Techniques for Investigation of Biophysical Signals in Patterning, in Analysis of growth factor signaling in embryos, M. Whitman and A.K. Sater, Editors. 2007, CRC/Taylor & Francis: Boca Raton, FL. p. 435 p.

Adams DS and M. Levin, Early Patterning of the Left/Right Axis, in Gastrulation, C.D. Stern, Editor 2004, Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. p. 16.

Koehl, M.A.R., Adams DS and R. Keller, Mechanical Development of the Notochord in Xenopus Early Tail-Bud Embryos, in Biomechanics of Active Movement and Deformation of Cells, N. Akkaş, Editor 1989, Springer-Verlag: Berlin.

Adams DS, Dynamic Mechanical Properties of Physarum Cytoplasm, in Biomechanics of Active Movement and Deformation of Cells, N. Akkaş, Editor 1989, Springer-Verlag: Berlin.

Pedagogy

Adams DS. Teaching critical thinking in a developmental biology course at an American liberal arts college. Int J Dev Biol 2003;47(2-3):145�151.

Adams DS A method for teaching controls. Dev Biol 2000;222(1):235�235.

Conference Abstracts/Proceedings

Adams DS, Blackiston, D., Lemire, J. Levin, M. Evidence of a Signaling Role for Developmentally Regulated Control of Ectodermal Cell Membrane Voltage: Human Craniofacial Dysmorphias and Tadpole Faces. Neural Crest & Cranial Placodes Gordon Research Conference. (2013)

Vandenberg, L.N. Adams DS Dramatic Changes in Membrane Voltage Prefigure Craniofacial Morphogenesis. Poster. Gordon Research Conference. 2010.

Adams DS A new tool for tissue engineers: ions as regulators of morphogenesis during development and regeneration. Tissue Engineering Part A. 2008:14(9): 1461-1468.

Levin, M., Adams DS, S. Aw, J. Morokuma, and N. Oviedo. Bioelectrical Controls of Morphogenesis. in Developmental Biology. 2006.

Adams DS., A. Masi, and M. Levin. Xenopus tadpole tail regeneration requires the activity of the proton pump V-ATPase, and proton pumping is sufficient to partially rescue the loss of function phenotype. in Developmental Biology. 2006.

Adams DS., T. Fukumoto, L. Kuo, and M. Levin. Ductin and Ion Flux in Pattern Formation. in The 2004 Northeast Regional meeting of The Society for Developmental Biology. 2004. Marine Biological Laboratory, Woods Hole, MA.

Nogi, T., Adams DS, and M. Levin. Electric controls of regeneration in planaria. in Developmental Biology. 2003.

Adams DS. and M. Levin. Elements of Left-Right Patterning: Gap Junctions, pH, and Membrane Voltage. in Developmental Biology. 2003.

Powell, J.A., Adams DS, J. Molgo, C. Colasante, A. Willams, M. Bohlen, and E. Jaimovich. IP3 receptors and associated calcium signals localize to components of the neuromuscular junction and satellite cells in skeletal muscle. in Biophysical Journal. 2002.

Powell, J.A., M.A. Carrasco, Adams DS, B. Drouet, J. Rios, M. Muller, M. Estrada, and E. Jaimovich. How your muscles know you've been working out: the IP3 pathway as a developmental signal in skeletal muscle. in Developmental Biology. 2001.

Adams DS. A Method for Teaching Controls. in Developmental Biology. 2000.

Powell, J.A., Adams DS, and E. Jaimovich. Subcellular Localization of IP3R in Cultured Skeletal Muscle. in Biophysical Society. 1999. Baltimore, MD: Biophysical Journal.

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