|
|
Klaus Miczek
Director, Behavioral Core of the Neuroscience Research Center, Sackler School of Biomedical Sciences
Professor of Psychology
Ph.D., University of Chicago, 1972
Klaus A. Miczek is the Moses Hunt Professor of
Psychology, Psychiatry, Pharmacology and Neuroscience at Tufts
University. He has served on research review committees for the National
Institute on Drug Abuse, National Institute on Mental Health, National
Institute on Alcoholism and Alcohol Abuse, and National Center for
Research Resources. He was a member of the National Academy of Science
panel on "Understanding and Preventing Violence" (1989-1992) as well as
its ILAR/NRC panel on the "Psychological Well-being of Primates." He is
the Coordinating and Principal Editor of Psychopharmacology since
1992, and he serves on the editorial board of half a dozen other
journals in this area. He was the president of the Division of
Psychopharmacology, and of the Behavioral Pharmacology Society, and
chaired the Committee on Animals in Research and Ethics of the American
Psychology Association. He has received numerous prizes including the
Solvay Duphar Award of the Division of Psychopharmacology and Substance
Abuse of the American Psychological Association, a MERIT award from
NIAAA, Silver Medals of the Charles University (Czech Republic). In
1997, the president of the Federal Republic of Germany bestowed the
Knight's Cross of the Order of Merit on him. Dr. Miczek was named the
Boerhaave professor at the medical faculty of Leiden University
(Netherlands) and was twice Japan International Science & Technology
Fellow at the University of Tokyo. He was visiting professor at La
Sapienza University in Rome, the Charles University in Prague and at the
University of Tuebingen (Germany). In 2006, Tufts University recognized
Dr. Miczek with the Distinguished Scholar Award, and he was elected
fellow in the American Association for the Advancement of Science. He
published some 200 research journal articles, 40 reviews and edited 20
volumes on psychopharmacological research concerning brain mechanisms of
aggression, anxiety, social stress and abuse of alcohol and other drugs.
He was originally educated in Berlin (Germany) and received his Ph.D. in
Biopsychology from the University of Chicago.
Currently, the work in Dr. Miczek's laboratory
investigates two problems in the areas of (1) stress and drug abuse, and
(2) behavioral neurobiology of aggression. First, members of the
laboratory aim to learn about neuroadaptive mechanisms via which
specific social stressors can intensify compulsive drug use or
alternatively engender depressive-like anhedonia. Second, they are
seeking to characterize the neurobiological features of those
individuals who engage in escalated aggression after alcohol
consumption. Selected high-impact publications in last ten years (from more than 250)
- Takahashi, A., Shimamoto, A., DeBold, J. F. and Miczek, K. A. GABAB
receptor modulation of serotonin neurons in the dorsal raph nucleus and
escalation of aggression in mice. Journal of Neuroscience 2010
30:11771-11780
- Takahashi, A., Kwa, C., DeBold, J.F. and Miczek, K. A. GABAA receptors
in the dorsal raph nucleus of mice in escalated aggression after alcohol
consumption. Psychopharmacology 2010 211:467-477
- Pautassi, R., Camarini, R., Quadros, I. M., Miczek, K. A. and Israel, Y.
Genetic and environmental influences on ethanol consumption: perspectives
from preclinical research. Alcoholism: Clinical and Experimental
Research 2010 34:976-987
- de Almeida, R. M. M., Saft, D. M., Rosa, M. M., and Miczek, K. A.
Flunitrazepam in combination with alcohol engenders high levels of
aggression in mice and rats. Pharmacology, Biochemistry and Behavior,
2010 95:292-297
- Yap, J. and Miczek, K. A. Stress and rodent models of drug addiction:
role of VTA-accumbens-PFC-amygdala circuit. Drug Discovery Today:
Disease Models 2008 5(4):259-270
- Velez, L., Sokoloff, G., Miczek, K.A., Palmer, A. A., and Dulawa, S. C.
Differences in aggressive behavior and DNA copy number variants between
BALB/cJ and BALB/cByJ. Behavior Genetics. 2010 40:201-210
- Chiavegatto, S., Quadros, I. M., Ambar, G., and Miczek, K. A. Selective
reduction of prefrontal cortex serotonin receptor gene expression in
alcohol-heightened aggressive mice. Genes, Brain and Behavior 2010
9:110-119
- Quadros, I. H. and Miczek, K. A. Two modes of intense cocaine bingeing:
increased persistence after social defeat stress and increased rate of
intake due to extended access conditions in rats. Psychopharmacology
2009 206:109-121
- Anstrom, K.K., Miczek, K. A., and Budygin, E. A. Increased phasic
dopamine signaling in the mesolimbic pathway during social defeat in rats.
Neuroscience 2009 161:3-12
- Takahashi, A., Yap, J. J., Bogager, D. Z., Faccidomo, S., Clayton, T.,
Cook, J. M. and Miczek, K. A. Glutamatergic and GABAergic modulation of
ultrasonic vocalizations during maternal separation distress in mouse pups.
Psychopharmacology 2009 204:61-72
- Centenaro, L. A., Vieira, K., Zimmermann, N., Miczek, K. A. Lucion, A. B.,
and de Almeida, R. M. M. Social instigation and aggressive behavior in mice:
role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex. Psychopharmacologyy
2008 201:237-248
- Cruz, F.C., Quadros, I. M., Planeta, C da S. and Miczek, K. A. Maternal
separation stress in mice: Long-term increases in alcohol intake. Psychopharmacologyy
2008 201:459-465
- Miczek, K. A., Covington, H. E., and Yap, J. J. Social stress, therapeutics
and drug abuse: preclinical models of escalated and depressed intake. Pharmacology
and Therapeutics 2008 (on line) McKenzie-Quirk, S. D. and Miczek, K. A.
Social separation and context: alcohol consumption in squirrel monkeys. Psychopharmacology
2008 120:102-128
- Miczek, K. A. and de Wit, H. Challenges for translational psychopharmacology
research some basic principles. Psychopharmacologyy 2008 199:291-301
- Faccidomo, S. P., Bannai, M. and Miczek, K. A. Escalated aggression after
alcohol drinking in male mice: prefrontal cortex serotonin and 5-HT1B receptors.
- Nikulina, E. M., Arrillaga-Romany. I., Miczek, K. A. and Hammer, R. P.,
Jr. Long-lasting cellular activation in mesocorticolimbic structures after repeated
social defeat stress in rats: time course of mu-opioid receptor mRNA and FosB/deltaFosB
immunoreactivity. European J. Neuroscience 2008 27:2272-2284
Neuropsychopharmacology 2008 33:2888-2899
- de Almeida, R.M.M., Benini, Q.; Betat, J.S., Hipolide, D. C., Miczek, K.
A., Svensson, A. I. Heightened aggression after chronic flunitrazepam in male
rats: Role of cortical and caudate-putamen binding sites. Psychopharmacology
2008 197:309-318
- Covington, H. E., Tropea, T., Rajadhyaksha, A., Kosofsky, B. E., and Miczek,
K. A. Intense cocaine taking and episodic social defeat stress in rats: Role
of NMDA receptors in the ventral tegmental area. Psychopharmacology 2008
197:203-216
View more entries >>
|