David E. Cochrane
Professor
Neural/endocrine signals on immune and inflammatory cell function

Publications

R.E.Carraway, S. Hassan, & D.E.Cochrane Regulation of neurotensin receptor fuction by the arachidonic acid-lipoxygenase pathway in prostate cancer PC3 cells  Prostagladins Leukotrienes and Essential Fatty Acids 2006 in press.

Richard C. Scarpa, Robert E. Carraway, and David E. Cochrane     Insulin-like growth factor (IGF) induced proliferation of human lung fibroblast is enhanced by neurotensin  Peptides, 2005 26, 2201-2210.

Richard C. Scarpa, Robert E. Carraway, and David E. Cochrane     The effect of neurotensin on insulin-induced proliferation of human fibroblasts    Peptides, 2004, 25, 1159-1169.

Theoharides, T.C, and D.E.Cochrane Critical role of mast cells in neuroinflammatory diseases J. Neuroimmunology 2004; 146 1-12.

Carraway, R.E., Hassan, S., Cochrane, D.E. Polyphenolic antioxidants mimic the effects of 1,4-dihydropyridines on neurotensin receptor function in PC3 cells. J. Pharmacol Exp Ter. 2004; Jan 12 (In press).

Caraway, R.E., Gui, X. and Cochrane, D.E. Ca 2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells. J. Pharmacol. Exp Therapeutics 2003 307: 640-650.

Cochrane,D.E b Carraway, R.E. aMiller L.A., aFeldbergR.S. and aBernheim, H. Histamine-Releasing Peptide (HRP) has proinflammatory effects and is present at sites of inflammation. Biochem. Pharmacol. 2003; 66 331-342

Pechenik JA, Wei LI, Cochrane DE Timing is everything: The effects of putative dopamine antagonists on metamorphosis vary with larval age and experimental duration in the Prosobranch gastropod Crepidula fronicata. Biol. Bul. 2002, 202: 137-147.

Cochrane,DE, Carraway,RE,, Feldberg,RS HRP, an albumin derived, protease generated pro-inflammatory peptide. Inflamm. Res. 2001 50:S195

Carraway,RE, Mitra,SP,,Cochrane DE Localization of maamalian pro-xenopsin to vesicle fractions of brain, liver, stomach. and intestine, and its presence in blood and cerebral spinal fluid. Regulatory Peptides 2000 95: 115-124

Harris MT, Feldberg RS, Lau KM, Lazarus NH, Cochrane DE. Expression of proinflammatory genes during estrogen-induced inflammation of the rat prostate. Prostate. 2000 Jun 15;44(1):19-25.

Alexacos N, Pang X, Boucher W, Cochrane DE, Sant GR, Theoharides TC. Neurotensin mediates rat bladder mast cell degranulation triggered by acute psychological stress.Urology. 1999 May;53(5):1035-40.

Barrocas AM, Cochrane DE, Carraway RE, Feldberg RS. Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C. Immunopharmacology. 1999 Feb;41(2):131-7.

Pang X, Alexacos N, Letourneau R, Seretakis D, Gao W, Boucher W, Cochrane DE, Theoharides TC. A neurotensin receptor antagonist inhibits acute immobilization stress-induced cardiac mast cell degranulation, a corticotropin-releasing hormone-dependent process. J Pharmacol Exp Ther. 1998 Oct;287(1):307-14.

Feldberg RS, Cochrane DE, Carraway RE, Brown E, Sawyer R, Hartunian M, Wentworth D. Evidence for a neurotensin receptor in rat serosal mast cells. Inflamm Res. 1998 Jun;47(6):245-50.

Miller LA, Cochrane DE, Feldberg RS, Carraway RE. Inhibition of neurotensin-stimulated mast cell secretion and carboxypeptidase A activity by the peptide inhibitor of carboxypeptidase A and neurotensin-receptor antagonist SR 48692. Int Arch Allergy Immunol. 1998 Jun;116(2):147-53.

Miller LA, Cochrane DE, Carraway RE, Feldberg RS. Blockade of mast cell histamine secretion in response to neurotensin by SR 48692, a nonpeptide antagonist of the neurotensin brain receptor. Br J Pharmacol. 1995 Apr;114(7):1466-70.

Cochrane DE, Carraway RE, Feldberg RS, Boucher W, Gelfand JM. Stimulated rat mast cells generate histamine-releasing peptide from albumin. Peptides. 1993 Mar-Apr;14(2):117-23.

Miller LA, Cochrane DE, Carraway RE, Feldberg RS. Inhibitory effects of the neurotensin8-13 analogs Asp13-NT8-13 and Asp12-NT8-13 on mast cell secretion. Agents Actions. 1993 Jan;38(1-2):1-7.

Eldred WD, Schutte M, Cochrane DE, Panula P. Immunocytochemical and biochemical studies of histamine in the retina of the turtle Pseudemys scripta. Cell Tissue Res. 1992 Mar;267(3):449-54.

Cochrane DE, Carraway RE, Boucher W. Histamine-releasing peptide is formed from albumin by stimulated rat mast cells. Ann N Y Acad Sci. 1992;668:333-4..

Carraway RE, Cochrane DE, Salmonsen R. Increased plasma levels of leukotrienes in response to neurotensin. Ann N Y Acad Sci. 1992;668:317-9..

Cochrane DE, Boucher W, Carraway RE. Formation of histamine-releasing activity from albumin by medium conditioned by endotoxin-stimulated rat peritoneal macrophages. Agents Actions. 1992 Jan;35(1-2):19-28.

Cochrane DE, Carraway RE, Boucher W, Feldberg RS. Rapid degradation of neurotensin by stimulated rat mast cells. Peptides. 1991 Nov-Dec;12(6):1187-94.

Cochrane DE, Carraway RE, Boucher W. Generation of xenopsin-related peptides from tissue precursors by media conditioned by endotoxin-stimulated rat peritoneal macrophages. Inflammation. 1991 Oct;15(5):381-90.

Carraway RE, Cochrane DE, Salmonsen R, Muraki K, Boucher W. Neurotensin elevates hematocrit and plasma levels of the leukotrienes, LTB4, LTC4, LTD4 and LTE4, in anesthetized rats. Peptides. 1991 Sep-Oct;12(5):1105-11.

Cochrane DE. Peptide regulation of mast-cell function. Prog Med Chem. 1990;27:143-88..

Carraway RE, Cochrane DE, Boucher W, Mitra SP. Structures of histamine-releasing peptides formed by the action of acid proteases on mammalian albumin(s). J Immunol. 1989 Sep 1;143(5):1680-4.

Cochrane DE, Boucher W, Carraway RE. Generation of histamine-releasing activity from serum albumin by medium derived from stimulated neutrophils of rat. Br J Pharmacol. 1989 Jun;97(2):524-32.

Carraway RE, Cochrane DE, Mitra SP. Xenopsin-related peptide generated in avian gastric extracts. Regul Pept. 1988 Sep;22(4):303-14.

Bibb PC, Cochrane DE. Replenishment of the cellular calcium required for non-immunologic stimulation of mast cell histamine secretion: temperature sensitivity and inhibition by manganese and sodium-free conditions. Agents Actions. 1988 Aug;25(1-2):27-36.

Cockerham LG, Pautler EL, Carraway RE, Cochrane DE, Hampton JD. Effect of disodium cromoglycate (DSCG) and antihistamines on postirradiation, cerebral blood flow and plasma levels of histamine and neurotensin. Fundam Appl Toxicol. 1988 Feb;10(2):233-42.

Feldberg RS, Iannitti DA, Cochrane DE. Histidine decarboxylase from rat mast cells. Enhanced recovery in cell-free extracts and isotopic labelling. Biochem J. 1988 Jan 1;249(1):297-300.

Cochrane DE, Boucher W, Carraway RE. Mast cell histamine-releasing activity from stimulated rat neutrophils. Int Arch Allergy Appl Immunol. 1988;87(3):269-74.

Carraway RE, Cochrane DE, Ruane SE. Isolation, structures, and biologic activity of neurotensin-related peptides generated in extracts of avian tissue. J Biol Chem. 1987 Nov 25;262(33):15886-9.

Carraway RE, Mitra SP, Cochrane DE. Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s). J Biol Chem. 1987 May 5;262(13):5968-73.

Slutsky B, Jarvis D, Bibb P, Feldberg RS, Cochrane DE. Viability and recovery from degranulation of isolated rat peritoneal mast cells. Exp Cell Res. 1987 Jan;168(1):63-78.

Bibb PC, Cochrane DE, Morel-Laurens N. Loss of quin 2 accompanies degranulation of mast cells. FEBS Lett. 1986 Dec 15;209(2):169-74.

Rosengard BR, Mahalik C, Cochrane DE. Mast cell secretion: differences between immunologic and non-immunologicstimulation. Agents Actions. 1986 Nov;19(3-4):133-40.

Cochrane DE, Boucher W, Bibb P. Neurotensin stimulates histamine release in in vivo skin 'blisters' in rats: an effect inhibited by cromolyn or somatostatin. Int Arch Allergy Appl Immunol. 1986;80(3):225-30.

Carraway RE, Cochrane DE, Granier C, Kitabgi P, Leeman E, Singer EA. Parallel secretion of endogenous 5-hydroxytryptamine and histamine from mast cells stimulated by vasoactive peptides and compound 48/80. Br J Pharmacol. 1984 Feb;81(2):227-9.

Rosengard BR, Cochrane DE. Complement-mediated cytolysis: a quick, simple method for determining levels ofimmunoglobulin E bound to mast cells. J Histochem Cytochem. 1983 Mar;31(3):441-4.

Cochrane DE, Distel DL. Association of 45calcium with rat mast cells stimulated by 48/80: effects of inactivation, calcium and metabolic inhibition. J Physiol. 1982 Sep;330:413-27. available.

Cochrane DE, Distel DL, Lansman JB, Paterson BM. Stimulus-secretion coupling in rat mast cells: inactivation of extracellular calcium dependent secretion. J Physiol. 1982 Feb;323:423-35.

Carraway R, Cochrane DE, Lansman JB, Leeman SE, Paterson BM, Welch HJ. Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol. 1982 Feb;323:403-14.

Chabot JA, Riback PS, Cochrane DE. Elevated cyclic AMP levels fail to inhibit extracellular calcium dependent histamine secretion from rat mast cells. Life Sci. 1981 Mar 9;28(10):1155-62.

Lansman JB, Cochrane DE. Wheat germ agglutinin stimulates exocytotic histamine secretion from rat mast cells in the absence of extracellular calcium. Biochem Pharmacol. 1980 Feb;29(3):455-8.

Cochrane DE, Douglas WW. Histamine release by exocytosis from rat mast cells on reduction of extracellular sodium: a secretory response inhibited by calcium, strontium, barium or magnesium. J Physiol. 1976 May;257(2):433-48.

Cochrane DE, Douglas WW, Mouri T, Nakazato Y. Calcium and stimulus-secretion coupling in the adrenal medulla: contrasting stimulating effects of the ionophores X-537A and A23187 on catecholamine output. J Physiol. 1975 Nov;252(2):363-78.

Parsons RL, Schnitzler RM, Cochrane DE. Inhibition of end-plate desensitization by sodium. Am J Physiol. 1974 Jul;227(1):96-100.

Cochrane DE, Douglas WW. Calcium-induced extrusion of secretory granules (exocytosis) in mast cells exposed to 48-80 or the ionophores A-23187 and X-537A. Proc Natl Acad Sci U S A. 1974 Feb;71(2):408-12.

Kanno T, Cochrane DE, Douglas WW. Exocytosis (secretory granule extrusion) induced by injection of calcium into mast cells. Can J Physiol Pharmacol. 1973 Dec;51(12):1001-4.

Cochrane DE, Parsons RL. The interaction between caffeine and calcium in the desensitization of muscle postjunctional membrane receptors. J Gen Physiol. 1972 Apr;59(4):437-61..

Simmons KR, Cochrane DE, Pomerantz DK. Bovine pituitary cytology: source of LH. J Anim Sci. 1970 Jan;30(1):73-8.

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